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Table 3 Multivariable logistic regression results for breed-related variables significantly associated with diagnosis of osteosarcoma amongst UK dogs

From: Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study

Variable

Variable P-value

Category

OR

95% CI

Category P-value

Purebred status

< 0.001

Crossbred

Base

  
  

Purebred

1.35

1.18–1.54

< 0.001

  

Unrecorded

0.52

0.33–0.79

0.003

KC Breed Group

< 0.001

Toy

Base

  
  

Gundog

14.48

9.72–21.58

< 0.001

  

Hound

21.54

14.14–32.81

< 0.001

  

Not_KC_Recognised

7.10

4.75–10.59

< 0.001

  

Pastoral

11.22

7.33–17.15

< 0.001

  

Terrier

3.87

2.54–5.90

< 0.001

  

Unrecorded

27.39

18.24–41.13

< 0.001

  

Utility

2.42

1.49–3.94

< 0.001

Body mass (kg)

< 0.001

< 10

Base

  
  

10–19.9

5.91

4.66–7.50

< 0.001

  

20–29.9

7.31

5.75–9.30

< 0.001

  

30–39.9

15.82

12.49–20.05

< 0.001

  

> 40

18.07

13.87–23.53

< 0.001

  

Unrecorded

0.15

0.10–0.22

< 0.001

Dachshund status

< 0.001

Non-Dachshund type

Base

  
  

Dachshund type

0.15

0.05–0.46

0.001

  

Unrecorded

0.70

0.61–0.79

< 0.001

Spaniel status

< 0.001

Non-Spaniel type

Base

  
  

Spaniel type

0.37

0.29–0.47

< 0.001

  

Unrecorded

0.65

0.57–0.74

< 0.001

Chondrodystrophy status

< 0.001

Non-chondrodystrophic

Base

  
  

Chondrodystrophic

0.13

0.11–0.16

< 0.001

  

Unrecorded

0.40

0.36–0.45

< 0.001

Skull shape

< 0.001

Mesocephalic

Base

  
  

Brachycephalic

0.39

0.32–0.48

< 0.001

  

Dolichocephalic

1.92

1.68–2.19

< 0.001

  1. Legend: Full multivariable logistic regression results for variables significantly associated with diagnosis of osteosarcoma amongst UK dogs. The main model included breed-name as the breed variable (Table 2), and six breed-related variables (purebred-status, Kennel Club breed group, body mass, dachshund-status, spaniel-status, chondrodystrophy status) then replaced breed-name in the model (Table 3). Cases were dogs with osteosarcoma confirmed by analysis of biopsies submitted to VPG Histology between 2008 and 2020 and controls were dogs enrolled in the VetCompassâ„¢ database during 2016