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  1. Research

    Prevalence of disorders recorded in Cavalier King Charles Spaniels attending primary-care veterinary practices in England

    Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from...

    Jennifer F Summers, Dan G O’Neill, David B Church, Peter C Thomson, Paul D McGreevy and David C Brodbelt

    Canine Genetics and Epidemiology 2015 2:4

    Published on: 18 April 2015

  2. Review

    The challenges of pedigree dog health: approaches to combating inherited disease

    The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnos...

    Lindsay L Farrell, Jeffrey J Schoenebeck, Pamela Wiener, Dylan N Clements and Kim M Summers

    Canine Genetics and Epidemiology 2015 2:3

    Published on: 11 February 2015

  3. Research

    Prevalence and risk factors for mast cell tumours in dogs in England

    Mast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk ...

    Stephanie JW Shoop, Stephanie Marlow, David B Church, Kate English, Paul D McGreevy, Anneliese J Stell, Peter C Thomson, Dan G O’Neill and David C Brodbelt

    Canine Genetics and Epidemiology 2015 2:1

    Published on: 26 January 2015

  4. Research

    Non-synonymous genetic variation in exonic regions of canine Toll-like receptors

    Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) considered to be the primary sensors of pathogens in innate immunity. Genetic variants could be associated to differences in breed innate imm...

    Anna Cuscó, Armand Sánchez, Laura Altet, Lluís Ferrer and Olga Francino

    Canine Genetics and Epidemiology 2014 1:11

    Published on: 22 October 2014

  5. Research

    A retrospective study of the prevalence of the canine degenerative myelopathy associated superoxide dismutase 1 mutation (SOD1:c.118G > A) in a referral population of German Shepherd dogs from the UK

    Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to o...

    Angela L Holder, James A Price, Jamie P Adams, Holger A Volk and Brian Catchpole

    Canine Genetics and Epidemiology 2014 1:10

    Published on: 25 September 2014

  6. Research

    Syringomyelia: determining risk and protective factors in the conformation of the Cavalier King Charles Spaniel dog

    Syringomyelia (SM) is a painful neurological condition, prevalent in brachycephalic toy breeds including the Cavalier King Charles Spaniel (CKCS). In these breeds, SM is typically secondary to Chiari-like Malf...

    Thomas J Mitchell, Susan P Knowler, Henny van den Berg, Jane Sykes and Clare Rusbridge

    Canine Genetics and Epidemiology 2014 1:9

    Published on: 29 July 2014

  7. Research

    Searching for "monogenic diabetes" in dogs using a candidate gene approach

    Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenc...

    Andrea D Short, Angela Holder, Simon Rothwell, Jonathan Massey, Rachel Scholey, Lorna J Kennedy, Brian Catchpole and William ER Ollier

    Canine Genetics and Epidemiology 2014 1:8

    Published on: 7 July 2014

  8. Review

    Holding back the genes: limitations of research into canine behavioural genetics

    Canine behaviours that are both desirable and undesirable to owners have a demonstrable genetic component. Some behaviours are breed-specific, such as the livestock guarding by maremmas and flank sucking seen ...

    Diane van Rooy, Elizabeth R Arnott, Jonathan B Early, Paul McGreevy and Claire M Wade

    Canine Genetics and Epidemiology 2014 1:7

    Published on: 10 June 2014

  9. Review

    What can cohort studies in the dog tell us?

    This paper addresses the use of cohort studies in canine medicine to date and highlights the benefits of wider use of such studies in the future. Uniquely amongst observational studies, cohort studies offer th...

    Carys A Pugh, Barend M de C Bronsvoort, Ian G Handel, Kim M Summers and Dylan N Clements

    Canine Genetics and Epidemiology 2014 1:5

    Published on: 15 May 2014

  10. Review

    Approaches to canine health surveillance

    Effective canine health surveillance systems can be used to monitor disease in the general population, prioritise disorders for strategic control and focus clinical research, and to evaluate the success of the...

    Dan G O’Neill, David B Church, Paul D McGreevy, Peter C Thomson and Dave C Brodbelt

    Canine Genetics and Epidemiology 2014 1:2

    Published on: 16 April 2014

  11. Review

    The genetics of eye disorders in the dog

    Inherited forms of eye disease are arguably the best described and best characterized of all inherited diseases in the dog, at both the clinical and molecular level and at the time of writing 29 different muta...

    Cathryn S Mellersh

    Canine Genetics and Epidemiology 2014 1:3

    Published on: 16 April 2014

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