Table 4 Non-synonymous SNPs and frameshift mutations of canine TLRs in the TaqMan Open Array plate
From: Non-synonymous genetic variation in exonic regions of canine Toll-like receptors
Canine gene | SNP | Chr:bp position | dbSNP ID | AA Subst | Previous detected a | Validated? |
|---|---|---|---|---|---|---|
TLR1 | G/T | 3:73542337 | rs23585044 | S29I | Massive seq | YES |
T/G | 3:73543092 | new | S281A | Massive seq | YES | |
G/A | 3:73543185 | new | V312I | Massive seq | YES | |
T/A | 3:73544153 | rs23572381 | N634K1 | CanFam 3.1 | YES2 | |
T/A | 3:73544153 | rs23572381 | N634K1 | CanFam 3.1 | NO | |
G/A | 3:73544221 | rs23572380 | S657N | CanFam 3.1 | YES2 | |
TLR2 | C/A | 15:51463020 | rs22410121 | S46Y | Massive seq | YES |
A/0 | 15:51464076 | rs8958543 | A398- | CanFam 3.1 | YES2 | |
C/T | 15:51464430 | new | S516L | Massive seq | YES | |
C/T | 15:51464700 | new | T606M | Massive seq | YES | |
TLR3 | C/G | 16:44623632 | new | E176D | Massive seq | YES |
TLR4 | T/C | 11:71356420 | rs22120766 | V8A | Massive seq | NO |
G/C | 11:71360743 | rs22157966 | A34P | Massive seq | YES | |
G/A | 11:71360887 | new | V82M | Massive seq | YES | |
T/C | 11:71364581 | rs22145736 | L167P | Massive seq | YES | |
C/A | 11:71364681 | rs22189454 | H200Q | Massive seq | YES | |
A/G | 11:71364769 | rs22189456 | K230E | Massive seq | YES | |
G/A | 11:71365120 | new | A347T | Massive seq | YES | |
A/T | 11:71365652 | rs22124023 | E524V | Massive seq | YES | |
A/G | 11:71365810 | new | T577A | Massive seq | YES | |
G/A | 11:71365888 | rs22123995 | E603K | Massive seq | YES | |
TLR5 | G/A | 38:23702193 | rs24029590 | G54E | CanFam 3.1 | NO |
0/C | 38:23702251 | rs9070448 | -74C | CanFam 3.1 | YES2 | |
A/G | 38:23702514 | rs9070450 | Y161C | CanFam 3.1 | NO | |
A/C | 38:23702539 | new | E169D | Massive seq | YES | |
G/A | 38:23702562 | new | S177N | Massive seq | YES | |
G/C | 38:23702640 | rs9070451 | R203P | Massive seq | YES | |
T/C | 38:23702684 | rs9070452 | W218R | Massive seq | NO | |
C/T | 38:23702837 | rs9070447 | R269C | Massive seq | YES | |
G/A | 38:23702918 | new | V296I | Massive seq | YES | |
T/C | 38:23703180 | new | L383S | Massive seq | YES | |
G/A | 38:23703237 | new | R402Q | Massive seq | YES | |
G/A | 38:23703279 | new | R416Q | Massive seq | YES | |
T/0 | 38:23703591 | rs9125247 | T520- | CanFam 3.1 | YES2 | |
G/A | 38:23703629 | new | G533S | Massive seq | YES | |
G/A | 38:23704233 | new | R734Q | Massive seq | YES | |
G/T | 38:23704331 | new | D767Y | Massive seq | YES | |
C/T | 38:23704562 | new | R844C | Massive seq | YES | |
T/C | 38:23704581 | rs24029975 | L850S | Massive seq | YES | |
T/G | 38:23704695 | new | F888C | Massive seq | YES | |
G/A | 38:23704718 | new | A896T | Massive seq | YES | |
C/T | 38:23705081 | new | H1017Y | Massive seq | YES | |
G/A | 38:23705090 | new | G1020S | Massive seq | YES | |
G/A | 38:23705178 | new | R1049Q | Massive seq | YES | |
G/A | 38:23705264 | new | A1078T | Massive seq | YES | |
TLR6 | A/G | 3:73521250 | new | Y182C | Massive seq | YES |
C/T | 3:73522074 | new | L457F | Massive seq | YES | |
G/A | 3:73522242 | rs23570247 | D513N | Massive seq | YES | |
TLR7 | C/G | X:9334108 | new | A16G | Massive seq | YES2 |
C/A | X:9355727 | new | F167L | Massive seq | YES | |
C/T | X:9358423 | new | P1066L | Massive seq | YES | |
TLR8 | T/C | X:9397240 | new | V157A | Massive seq | YES |
G/A | X:9397663 | new | R298Q | Massive seq | YES | |
G/A | X:9398094 | rs24607342 | G442S | Massive seq | YES | |
G/A | X:9398827 | rs24607358 | R686H | Massive seq | YES | |
TLR9 | G/A | 20:37544129 | new | V87I | Massive seq | YES |
0/A | 20:37544851 | rs9188882 | -328A | CanFam 3.1 | YES2 | |
A/G | 20:37545011 | new | K381E | Massive seq | YES | |
C/A | 20:37545245 | new | P459T | Massive seq | YES | |
A/G | 20:37546031 | rs22882109 | S721G | Massive seq | YES | |
C/T | 20:37546230 | new | P787L | Massive seq | ND3 | |
C/T | 20:37546454 | new | R862W | Massive seq | YES | |
TLR10 | C/T | 3:73569402 | rs23518574 | T361M | Massive seq | YES |
A/G | 3:73570094 | new | M592V | Massive seq | YES |