Figure 1
From: A novel mutation in TTC8 is associated with progressive retinal atrophy in the golden retriever
Genome-wide association mapping of PRA in Golden Retrievers. -Log10 of p-values after correction for multiple testing and population stratification with 100,000 permutations and IBS clustering, respectively. (A) -Log10 plot of genome-wide association results show a single, albeit not statistically significant, signal on CFA8 (praw = 8.99 × 10-5, pgenome = 0.148). The most significant of the raw and permuted values are indicated. (B) The associated SNPs on CFA8 form two distinct signals with the most associated SNPs at 63.614 Mb and 71.732 Mb. Permuted values at these loci are indicated.