From: Searching for "monogenic diabetes" in dogs using a candidate gene approach
Gene | Protein | SNP IDs | Type of monogenic diabetes in humans | Associated literature | |
---|---|---|---|---|---|
ABCC8 | Sulfonylurea receptor 1 | rs9183439 | rs22988565 | PNDM, TNDM | [33] |
 |  | rs22993873 | rs9044450 |  | [34] |
BLK | B lymphoid tyrosine kinase | rs23277058 | rs23242723 | MODY 11 | [35] |
 |  | rs23228211 | rs23268052 |  | [36] |
Cel | Carboxyl ester lipase | rs8843005 | rs8843006 | MODY 8 (with exocrine dysfunction) | [37] |
 |  | rs24549495 |  |  | |
EIF2AK3 | Eukaryotic translation | rs22578314 | rs9179252 | PNDM (with epiphyseal dysplasia) | [40] |
 | initiation factor 2a kinase | rs22578182 | rs22566811 |  |  |
FOXP3 | Forkhead box P3 | rs24618205 | rs24596299 | PNDM (X-linked with immune-dysregulation, polyendocrinopathy, enteropathy) | [41] |
 |  | rs24612921 |  |  | [42] |
HNF1A | Hepatocyte nuclear factor 1a | rs23350532 | rs9013694 | MODY 3 | [43] |
 |  | rs23309484 |  |  | [20] |
HNF1B | Hepatocyte nuclear factor 1b | rs24537168 | rs24585301 | MODY 5 (also with renal dysfunction, genital malformations) and PNDM | [44] |
 |  | rs24537175 | rs24585484 |  |  |
HNF4A | Hepatocyte nuclear factor 4a | rs23214782 | rs23200327 | MODY 1 | [43] |
 |  | rs8804236 | rs23200360 |  | [45] |
 |  | rs23214781 | rs9006559 |  | [16] |
INS | Insulin | rs22686871 | Â | PNDM, MODY | [23] |
KLF11 | Kruppel-like factor 11 | rs22598321 | rs8803647 | MODY 7 | [46] |
MTTL1 | Transfer RNA for protein | rs8648077 | rs8884972 | Mitochondrial diabetes (maternally transmitted with deafness) | [47] |
 | translation | rs24305581 |  |  | [48] |
PAX4 | Paired box 4 | rs22302371 | rs22302353 | MODY 9 | [49] |
PDX1 | Â | rs8837751 | rs8837750 | MODY 4, PNDM (with pancreatic agenesis) | [50] |
 | Insulin promoter factor 1 |  | rs23247540 |  | [21] |
PTF1A | Pancreas-specific | rs8955054 | rs8955053 | PNDM (with pancreatic and cerebellar agenesis) | [51] |
 | transcription factor 1a | rs8955055 |  |  |  |
RFX6 | Regulatory factor X6 | rs8928516 | rs21958946 | PNDM (with hypoplastic pancreas and gall bladder, intestinal atresia) | [52] |
 |  | rs21890992 |  |  |  |
WFS1 | Â | rs24739532 | Â | PNDM (with diabetes insipidus, optic atrophy, deafness) | [53] |
 | Wolframin |  |  |  | [54] |
ZFP57 | Zinc finger protein 57 | rs23901704 | rs23892119 | TNDM | [55] |
 |  | rs23892118 | rs23901705 |  |  |
ZAC1/PLAG1 | Pleiomorphic adenoma gene-like 1 | rs23483681 | Â | TNDM | Â |