Ten inherited disorders in purebred dogs by functional breed groupings

Oberbauer, A. M.; Belanger, J. M.; Bellumori, T.; Bannasch, D. L.; Famula, T. R.

doi:10.1186/s40575-015-0021-x

Canine Medicine and Genetics

Table 1 Disorder counts, prevalence % (prev), and 95 % confidence interval (low and high) for inherited disorders between purebred dog categories and the mixed-breed dog population diagnosed over a 15-year period

From: Ten inherited disorders in purebred dogs by functional breed groupings

	No. of normal	No. of affected	Prev	Low	High	No. of normal	No. of affected	Prev	Low	High	No. of normal	No. of affected	Prev	Low	High	No. of normal	No. of affected	Prev	Low	High	No. of normal	No. of affected	Prev	Low	High
	Aortic stenosis					Atopyl/allergic dermititis					Gastric dilatation volvulus					Early onset cataracts					Dilated cardiomyopathy
AKC group
Mixed breed	22,649	34	0.15	0.10	0.20	22,437	246	1.08	0.95	1.21	22,638	45	0.20	0.14	0.26	21,767	916	4.04	3.78	4.30	22,647	36	0.16	0.11	0.21
Herding	9678	46	0.47	0.33	0.61	9604	120	1.23	1.01	1.45	9685	39	0.40	0.27	0.53	9377	347	3.57	3.20	3.94	9712	12	0.12	0.05	0.19
Hound	5331	13	0.24	0.11	0.37	5280	64	1.20	0.91	1.49	5329	15	0.28	0.14	0.42	5130	214	4.00	3.47	4.53	5317	27	0.51	0.32	0.70
Non-sporting	6491	25	0.38	0.23	0.53	6345	171	2.62	2.23	3.01	6489	27	0.41	0.25	0.57	5965	551	8.46	7.78	9.14	6508	8	0.12	0.03	0.21
Sporting	18,849	91	0.48	0.38	0.58	18,574	366	1.93	1.73	2.13	18,884	56	0.30	0.22	0.38	18,006	934	4.93	4.62	5.24	18,848	92	0.49	0.39	0.59
Terrier	4870	15	0.31	0.15	0.47	4730	155	3.17	2.68	3.66	4879	6	0.12	00.02	0.22	4557	328	6.71	6.01	7.41	4879	6	0.12	0.02	0.22
Toy	9773	25	0.26	0.16	0.36	9645	153	1.56	1.31	1.81	9795	3	0.03	0.00	0.06	8995	803	8.20	7.66	8.74	9794	4	0.04	0.00	0.08
Working	10,562	183	1.70	1.46	1.94	10,632	113	1.05	0.86	1.24	10,670	75	0.70	0.54	0.86	10,439	306	2.85	2.54	10538	207	1.93	1.67	2.19
Haplotype group
Mixed breed	22,649	34	0.15	0.10	0.20	22,437	246	1.08	0.95	1.21	22,638	45	0.20	0.14	0.26	21,767	916	4.04	3.78	4.30	22,647	36	0.16	0.11	0.21
Ancient and spitz	2937	9	0.31	0.11	0.51	2910	36	1.22	0.82	1.62	2927	19	0.64	0.35	0.93	2795	151	5.13	4.33	5.93	2936	10	0.34	0.13	0.55
Herding	4568	11	0.24	0.10	0.38	4524	55	1.20	0.88	1.52	4573	6	0.13	0.03	0.23	4383	196	4.28	3.69	4.87	4577	2	0.04	−0.02	0.10
Mastiff-like	5443	105	1.89	1.53	2.25	5431	117	2.11	1.73	2.49	5534	14	0.25	0.12	0.38	5278	270	4.87	4.30	5.44	5494	54	0.97	.71	1.23
Retriever	18,181	166	0.90	0.75	1.04	18,032	315	1.72	1.53	1.91	18,269	78	0.43	0.34	0.52	17,783	564	3.07	2.82	3.32	18,231	116	0.63	0.52	0.74
Scent hound	3738	4	0.11	0.01	0.21	3692	50	1.34	0.97	1.71	3738	4	0.11	0.01	0.21	3558	184	4.92	4.23	5.61	3740	2	0.05	−0.02	0.12
Sight hound	757	4	0.53	0.02	1.04	757	4	0.53	0.02	1.04	755	6	0.76	0.16	1.42	744	17	2.23	1.18	3.28	745	15	1.97	0.98	2.96
Small terrier	2532	2	0.08	–0.08	0.19	2438	96	3.79	3.05	4.53	2533	1	0.04	–0.04	0.12	2369	165	6.51	5.55	7.47	5232	2	0.08	–0.03	0.19
Spaniel	4309	6	0.14	0.03	0.25	4239	76	1.76	1.37	2.15	4305	10	0.23	0.09	0.37	3884	431	9.99	9.10	10.88	4274	41	0.95	0.66	1.24
Toy	5524	18	0.32	0.17	0.47	5461	81	1.46	1.14	1.78	5541	1	0.02	−0.02	0.06	5204	338	6.10	5.47	6.73	5540	2	0.04	−0.04	0.09
Working group 1	1911	0	0.00	0.00	0.00	1883	28	1.47	0.93	2.01	1887	14	0.73	0.35	1.11	1666	245	12.82	11.32	14.32	1908	3	0.16	−0.02	0.34
Working group 2	5088	28	0.55	0.35	0.75	5044	72	1.41	1.09	1.73	5072	44	0.86	0.61	1.11	4981	135	2.64	2.20	3.08	5034	82	1.60	1.26	1.94
	Elbow dysplasia					Epilepsy					Hypothyroidism					Intervertebral disk disease					Portosystemic shunt
AKC group
Mixed breed	22,479	204	0.90	0.78	1.02	22,477	206	0.91	0.79	1.03	22,334	349	1.54	1.38	1.70	21,679	1004	4.43	4.16	4.70	22,604	79	0.35	0.27	0.43
Herding	9555	169	1.74	1.48	2.00	9574	150	1.54	1.30	1.78	9553	171	1.76	1.50	2.02	9057	667	6.86	6.36	7.36	9695	29	0.30	0.19	0.41
Hound	5324	20	0.37	0.21	0.53	5270	74	1.38	1.07	1.69	5244	100	1.87	1.51	2.23	4278	1066	19.95	18.88	21.02	5313	31	0.58	0.38	0.79
Non-sporting	6481	35	054	0.36	0.72	6422	94	1.44	1.15	1.73	6387	129	1.98	1.64	2.32	6112	404	6.20	5.61	6.79	6488	28	0.43	0.27	0.59
Sporting	18,447	493	2.60	2.37	2.83	18,667	273	1.44	1.27	1.61	18,409	531	2.80	2.56	3.04	18,176	764	4.03	3.75	4.31	18,864	76	0.40	0.31	0.49
Terrier	4862	23	0.47	0.28	0.66	4844	41	0.84	0.58	1.10	4809	76	1.56	1.21	1.91	4711	174	3.56	3.04	4.08	4816	69	1.41	1.08	1.74
Toy	9791	7	0.07	0.02	0.12	9674	124	1.27	1.05	1.49	9675	123	1.23	1.04	1.48	9221	577	5.89	5.42	6.36	9412	386	3.94	3.55	4.33
Working	10,345	400	3.72	3.36	3.36	4.08	10,669	76	0.71	0.55	0.87	10438	307	2.86	2.54	3.18	10,062	683	6.36	5.90	10,712	33	0.31	0.21	0.41
Haplotype group
Mixed breed	22,479	204	0.90	0.78	1.02	22,477	206	0.91	0.79	1.03	22,334	349	1.54	1.38	1.70	21,679	1004	4.43	4.16	4.70	22,604	79	0.35	0.27	0.43
Ancient and spitz	2916	30	1.02	0.66	1.38	2906	40	1.36	0.94	1.78	2848	98	3.33	2.68	3.98	2810	136	4.62	3.86	5.38	2937	9	0.31	0.11	0.51
Herding	4553	26	0.57	0.35	0.79	4487	92	2.01	1.60	2.42	4477	102	2.23	1.80	2.66	4344	235	5.13	4.49	5.77	4555	24	0.52	0.31	0.73
Mastiff-like	5482	66	1.19	0.09	1.48	5496	52	0.94	0.69	1.19	5471	77	1.39	1.08	1.70	5263	285	5.14	4.56	5.72	5524	24	0.43	0.26	0.60
Retriever	17,557	790	4.31	4.02	4.60	18,145	202	1.10	0.95	1.25	17,876	471	2.57	2.34	2.80	17,522	825	4.50	4.20	4.80	18,279	68	0.37	0.28	0.45
Scent hound	3733	9	0.24	0.08	0.40	3686	56	1.50	1.11	1.89	3681	61	1.63	1.22	2.04	2760	982	26.24	24.83	27.65	3718	24	0.64	0.38	0.90
Sight hound	760	1	0.13	−0.13	0.39	750	11	1.45	0.60	2.30	748	13	1.71	0.79	2.63	706	55	7.23	5.39	9.07	755	6	0.79	0.16	1.42
Small terrier	2532	2	0.08	−0.03	0.19	2513	21	0.83	0.48	1.18	2503	31	1.22	0.79	1.65	2463	71	2.80	2.16	3.44	2367	167	6.59	5.62	7.56
Spaniel	4302	13	0.30	0.14	0.46	4235	80	1.85	1.45	2.25	4191	124	2.87	2.37	3.37	4112	202	4.68	4.05	5.31	4299	16	0.37	0.19	0.55
Toy	5539	3	0.05	−0.01	0.11	5473	69	1.25	0.96	1.54	5477	65	1.17	0.89	1.45	5153	389	7.02	6.35	7.69	5383	159	2.87	2.43	3.31
Working group 1	1908	3	0.16	−0.02	0.34	1869	42	2.20	1.54	2.86	1882	29	1.52	0.97	2.07	1819	92	4.81	3.85	5.77	1885	26	1.36	0.84	1.88
Working group 2	4992	124	2.42	2.00	2.84	5055	61	1.19	0.89	1.49	4998	118	2.31	1.90	2.72	4594	522	10.20	9.37	11.03	5107	9	0.18	0.07	0.29

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