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Table 1 Disorder counts, prevalence % (prev), and 95 % confidence interval (low and high) for inherited disorders between purebred dog categories and the mixed-breed dog population diagnosed over a 15-year period

From: Ten inherited disorders in purebred dogs by functional breed groupings

  No. of normal No. of affected Prev Low High No. of normal No. of affected Prev Low High No. of normal No. of affected Prev Low High No. of normal No. of affected Prev Low High No. of normal No. of affected Prev Low High
  Aortic stenosis Atopyl/allergic dermititis Gastric dilatation volvulus Early onset cataracts Dilated cardiomyopathy
AKC group                          
 Mixed breed 22,649 34 0.15 0.10 0.20 22,437 246 1.08 0.95 1.21 22,638 45 0.20 0.14 0.26 21,767 916 4.04 3.78 4.30 22,647 36 0.16 0.11 0.21
 Herding 9678 46 0.47 0.33 0.61 9604 120 1.23 1.01 1.45 9685 39 0.40 0.27 0.53 9377 347 3.57 3.20 3.94 9712 12 0.12 0.05 0.19
 Hound 5331 13 0.24 0.11 0.37 5280 64 1.20 0.91 1.49 5329 15 0.28 0.14 0.42 5130 214 4.00 3.47 4.53 5317 27 0.51 0.32 0.70
 Non-sporting 6491 25 0.38 0.23 0.53 6345 171 2.62 2.23 3.01 6489 27 0.41 0.25 0.57 5965 551 8.46 7.78 9.14 6508 8 0.12 0.03 0.21
 Sporting 18,849 91 0.48 0.38 0.58 18,574 366 1.93 1.73 2.13 18,884 56 0.30 0.22 0.38 18,006 934 4.93 4.62 5.24 18,848 92 0.49 0.39 0.59
 Terrier 4870 15 0.31 0.15 0.47 4730 155 3.17 2.68 3.66 4879 6 0.12 00.02 0.22 4557 328 6.71 6.01 7.41 4879 6 0.12 0.02 0.22
 Toy 9773 25 0.26 0.16 0.36 9645 153 1.56 1.31 1.81 9795 3 0.03 0.00 0.06 8995 803 8.20 7.66 8.74 9794 4 0.04 0.00 0.08
 Working 10,562 183 1.70 1.46 1.94 10,632 113 1.05 0.86 1.24 10,670 75 0.70 0.54 0.86 10,439 306 2.85 2.54 10538 207 1.93 1.67 2.19  
Haplotype group
 Mixed breed 22,649 34 0.15 0.10 0.20 22,437 246 1.08 0.95 1.21 22,638 45 0.20 0.14 0.26 21,767 916 4.04 3.78 4.30 22,647 36 0.16 0.11 0.21
 Ancient and spitz 2937 9 0.31 0.11 0.51 2910 36 1.22 0.82 1.62 2927 19 0.64 0.35 0.93 2795 151 5.13 4.33 5.93 2936 10 0.34 0.13 0.55
 Herding 4568 11 0.24 0.10 0.38 4524 55 1.20 0.88 1.52 4573 6 0.13 0.03 0.23 4383 196 4.28 3.69 4.87 4577 2 0.04 −0.02 0.10
 Mastiff-like 5443 105 1.89 1.53 2.25 5431 117 2.11 1.73 2.49 5534 14 0.25 0.12 0.38 5278 270 4.87 4.30 5.44 5494 54 0.97 .71 1.23
 Retriever 18,181 166 0.90 0.75 1.04 18,032 315 1.72 1.53 1.91 18,269 78 0.43 0.34 0.52 17,783 564 3.07 2.82 3.32 18,231 116 0.63 0.52 0.74
 Scent hound 3738 4 0.11 0.01 0.21 3692 50 1.34 0.97 1.71 3738 4 0.11 0.01 0.21 3558 184 4.92 4.23 5.61 3740 2 0.05 −0.02 0.12
 Sight hound 757 4 0.53 0.02 1.04 757 4 0.53 0.02 1.04 755 6 0.76 0.16 1.42 744 17 2.23 1.18 3.28 745 15 1.97 0.98 2.96
 Small terrier 2532 2 0.08 –0.08 0.19 2438 96 3.79 3.05 4.53 2533 1 0.04 –0.04 0.12 2369 165 6.51 5.55 7.47 5232 2 0.08 –0.03 0.19
 Spaniel 4309 6 0.14 0.03 0.25 4239 76 1.76 1.37 2.15 4305 10 0.23 0.09 0.37 3884 431 9.99 9.10 10.88 4274 41 0.95 0.66 1.24
 Toy 5524 18 0.32 0.17 0.47 5461 81 1.46 1.14 1.78 5541 1 0.02 −0.02 0.06 5204 338 6.10 5.47 6.73 5540 2 0.04 −0.04 0.09
 Working group 1 1911 0 0.00 0.00 0.00 1883 28 1.47 0.93 2.01 1887 14 0.73 0.35 1.11 1666 245 12.82 11.32 14.32 1908 3 0.16 −0.02 0.34
 Working group 2 5088 28 0.55 0.35 0.75 5044 72 1.41 1.09 1.73 5072 44 0.86 0.61 1.11 4981 135 2.64 2.20 3.08 5034 82 1.60 1.26 1.94
  Elbow dysplasia Epilepsy Hypothyroidism Intervertebral disk disease Portosystemic shunt
AKC group
 Mixed breed 22,479 204 0.90 0.78 1.02 22,477 206 0.91 0.79 1.03 22,334 349 1.54 1.38 1.70 21,679 1004 4.43 4.16 4.70 22,604 79 0.35 0.27 0.43
 Herding 9555 169 1.74 1.48 2.00 9574 150 1.54 1.30 1.78 9553 171 1.76 1.50 2.02 9057 667 6.86 6.36 7.36 9695 29 0.30 0.19 0.41
 Hound 5324 20 0.37 0.21 0.53 5270 74 1.38 1.07 1.69 5244 100 1.87 1.51 2.23 4278 1066 19.95 18.88 21.02 5313 31 0.58 0.38 0.79
 Non-sporting 6481 35 054 0.36 0.72 6422 94 1.44 1.15 1.73 6387 129 1.98 1.64 2.32 6112 404 6.20 5.61 6.79 6488 28 0.43 0.27 0.59
 Sporting 18,447 493 2.60 2.37 2.83 18,667 273 1.44 1.27 1.61 18,409 531 2.80 2.56 3.04 18,176 764 4.03 3.75 4.31 18,864 76 0.40 0.31 0.49
 Terrier 4862 23 0.47 0.28 0.66 4844 41 0.84 0.58 1.10 4809 76 1.56 1.21 1.91 4711 174 3.56 3.04 4.08 4816 69 1.41 1.08 1.74
 Toy 9791 7 0.07 0.02 0.12 9674 124 1.27 1.05 1.49 9675 123 1.23 1.04 1.48 9221 577 5.89 5.42 6.36 9412 386 3.94 3.55 4.33
 Working 10,345 400 3.72 3.36 3.36 4.08 10,669 76 0.71 0.55 0.87 10438 307 2.86 2.54 3.18 10,062 683 6.36 5.90 10,712 33 0.31 0.21 0.41
Haplotype group
 Mixed breed 22,479 204 0.90 0.78 1.02 22,477 206 0.91 0.79 1.03 22,334 349 1.54 1.38 1.70 21,679 1004 4.43 4.16 4.70 22,604 79 0.35 0.27 0.43
 Ancient and spitz 2916 30 1.02 0.66 1.38 2906 40 1.36 0.94 1.78 2848 98 3.33 2.68 3.98 2810 136 4.62 3.86 5.38 2937 9 0.31 0.11 0.51
 Herding 4553 26 0.57 0.35 0.79 4487 92 2.01 1.60 2.42 4477 102 2.23 1.80 2.66 4344 235 5.13 4.49 5.77 4555 24 0.52 0.31 0.73
 Mastiff-like 5482 66 1.19 0.09 1.48 5496 52 0.94 0.69 1.19 5471 77 1.39 1.08 1.70 5263 285 5.14 4.56 5.72 5524 24 0.43 0.26 0.60
 Retriever 17,557 790 4.31 4.02 4.60 18,145 202 1.10 0.95 1.25 17,876 471 2.57 2.34 2.80 17,522 825 4.50 4.20 4.80 18,279 68 0.37 0.28 0.45
 Scent hound 3733 9 0.24 0.08 0.40 3686 56 1.50 1.11 1.89 3681 61 1.63 1.22 2.04 2760 982 26.24 24.83 27.65 3718 24 0.64 0.38 0.90
 Sight hound 760 1 0.13 −0.13 0.39 750 11 1.45 0.60 2.30 748 13 1.71 0.79 2.63 706 55 7.23 5.39 9.07 755 6 0.79 0.16 1.42
 Small terrier 2532 2 0.08 −0.03 0.19 2513 21 0.83 0.48 1.18 2503 31 1.22 0.79 1.65 2463 71 2.80 2.16 3.44 2367 167 6.59 5.62 7.56
 Spaniel 4302 13 0.30 0.14 0.46 4235 80 1.85 1.45 2.25 4191 124 2.87 2.37 3.37 4112 202 4.68 4.05 5.31 4299 16 0.37 0.19 0.55
 Toy 5539 3 0.05 −0.01 0.11 5473 69 1.25 0.96 1.54 5477 65 1.17 0.89 1.45 5153 389 7.02 6.35 7.69 5383 159 2.87 2.43 3.31
 Working group 1 1908 3 0.16 −0.02 0.34 1869 42 2.20 1.54 2.86 1882 29 1.52 0.97 2.07 1819 92 4.81 3.85 5.77 1885 26 1.36 0.84 1.88
 Working group 2 4992 124 2.42 2.00 2.84 5055 61 1.19 0.89 1.49 4998 118 2.31 1.90 2.72 4594 522 10.20 9.37 11.03 5107 9 0.18 0.07 0.29