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Table 2 Odds ratios of inherited disorders between purebred dog categories and the mixed-breed dog population diagnosed over a 15-year period

From: Ten inherited disorders in purebred dogs by functional breed groupings

  OR (CI) P value No. OR (CI) P value No. OR (CI) P value No. OR (CI) P value No. OR (CI) P value No.
  Aortic stenosis Atopy/allergic dermatitis Gastric dilatation volvulus Early onset cataracts Dilated cardiomyopathy
AKC Group
 Herding 2.25(1.25–4.05) 0.02 44 1.06(0.79–1.43) 0.58 0 1.63(0.83–3.23) 0.23 9 0.99(0.82–1.20) 0.67 0 0.73(0.34–1.56) 0.45 0
 Hound 1.50(0.66–3.45) 0.41 4 1.20(0.82–1.76) 0.14 2 2.72(1.01–7.34) 0.09 37 0.83(0.66–1.03) 0.13 15 4.98(2.29–10.83) 0.00 50
 Non-sporting 2.00(0.98–4.08) 0.09 26 2.49(1.83–3.38) 0.00 50 3.45(1.51–7.88) 0.01 46 1.72(1.44–2.06) 0.00 50 0.91(0.34–2.39) 0.63 0
 Sporting 2.10(1.25–3.52) 0.02 45 1.71(1.35–2.16) 0.00 50 1.20(0.67–2.14) 0.52 0 1.61(1.38–1.87) 0.00 50 2.40(1.45–3.97) 0.00 50
 Terrier 2.02(0.84–4.87) 0.19 13 2.98(2.11–4.21) 0.00 50 1.33(0.33–5.38) 0.60 0 0.95(0.78–1.15) 0.52 0 0.86(0.24–3.08) 0.58 0
 Toy 1.81(0.81–4.09) 0.22 7 1.76(1.23–2.47) 0.01 46 0.90(0.14–5.73) 0.20 0 1.16(0.98–1.37) 0.13 21 0.66(0.14–3.07) 0.56 0
 Working 6.26(3.74–10.45) 0.00 50 0.96(0.71–1.31) 0.65 0 2.45(1.34–4.48) 0.01 48 1.23(1.00–1.52) 0.11 24 11.60(6.87–19.50) 0.00 50
Haplotype group
 Ancient and spitz 1.49(0.58–3.79) 0.44 0 1.15(0.71–1.85) 0.56 1 2.27(0.87–5.91) 0.15 16 1.35(1.02–1.79) 0.08 26 1.88(0.77–4.60) 0.25 6
 Herding 1.17(0.48–2.89) 0.59 0 0.97(0.65–1.47) 0.61 0 0.29(0.06–1.42) 0.16 11 0.91(0.72–1.15) 0.45 0 0.26(0.06–1.19) 0.09 12
 Mastiff-like 8.30(4.59–15.02) 0.00 50 2.11(1.50–2.97) 0.00 50 1.42(0.58–3.50) 0.49 4 1.44(1.15–1.81) 0.01 48 7.24(3.76–13.95) 0.00 50
 Retriever 3.76(2.27–6.23) 0.00 50 (1.22–2.02) 0.01 49 1.63(0.93–2.85) 1.15 16 1.26(1.05–1.51) 0.05 38 3.22(.195–5.32) 0.00 50
 Scent hound 0.92(0.24–3.53) 0.63 0 1.46(0.92–2.30) 0.18 16 2.27(0.38–13.49) 0.43 0 0.93(0.73–1.19) 0.54 0 0.90(0.16–4.94) 0.68 0
 Sight hound 2.77(0.61–12.55) 0.28 3 0.47(0.15–1.48) 0.22 3 4.16(0.81–21.45) 0.16 15 0.55(0.28–1.08) 0.13 19 14.72(3.88–55.84) 0.00 50
 Small terrier 0.51(0.09–3.03) 0.45 0 3.86(2.45–6.08) 0.00 50 0.71(0.04–13.40) 0.72 0 0.87(0.67–1.12) 0.33 2 1.95(0.22–17.08) 0.62 0
 Spaniel 0.57(0.17–1.93) 0.38 0 1.57(1.07–2.32) 0.06 35 1.94(0.65–5.74) 0.32 3 1.88(1.54–2.30) 0.00 50 6.01(2.72–13.28) 0.00 50
 Toy 1.91(0.74–4.93) 0.25 8 1.62(1.07–2.44) 0.05 35 0.52(0.03–8.73) 0.63 0 0.88(0.72–1.09) 0.30 6 1.13(0.15–8.26) 0.62 0
 Working group 1 0.56(0.04–9.54) 0.98 0 1.75(0.98–3.13) 0.12 21 80.03(1.93–13.45) 0.04 47 2.17(1.65–2.85) 0.00 50 1.78(0.38–8.37) 0.53 0
 Working group 2 2.45(1.24–4.) 0.03 43 1.26(.087–1.83) 0.29 5 3.40(1.65–7.04) 0.01 48 0.89(0.67–1.18) 0.43 2 7.42(4.08–13.50) 0.00 50
  Elbow dysplasia Epilepsy Hypothyroidism IVDD Portosystemic shunt
AKC group
 Herding 1.65(1.23–2.21) 0.00 48 1.57(1.14–2–2.16) 0.02 44 1.11(0.86–1.42) 0.46 1 1.53(1.31–1.79) 0.00 50 0.86(0.49–1.53) 0.56 0
 Hound 0.76(0.43–1.43) 0.40 2 1.65(1.09–2.50) 0.05 38 1.53(1.09–2.13) 0.04 37 4.54(3.82–5.40) 0.00 50 1.12(0.62–1.93) 0.59 0
 Non-sporting 0.72(0.45–1.16) 0.23 7 1.49(1.02–2.17) 0.08 31 1.43(1.06–1.92) 0.04 37 1.31(1.10–1.56) 0.01 48 0.80(0.47–1.38) 0.46 3
 Sporting 2.25(1.79–2.82) 0.00 50 1.51(1.15–1.98) 0.02 45 1.69(1.40–2.06) 0.00 50 0.93(0.81–1.07) 0.37 2 1.43(0.90–2.28) 0.21 14
 Terrier 1.37(0.74–2.55) 0.37 1 0.93(0.58–1.50) 0.56 1 1.18(0.82–1.70) 0.43 4 0.57(0.46–0.71) 0.00 50 2.00(1.27–3.13) 0.01 46
 Toy 0.67(0.19–2–40) 0.52 1 1.50(1.01–2.24) 0.09 26 1.31(0.91–1.88) 0.21 11 0.99(0.84–1.18) 0.65 0 4.15(2.89–5.96) 0.00 50
 Working 2.89(2.25–3.70) 0.00 50 0.80(0.55–1.15) 0.28 5 2.17(1.72–2.74) 0.00 50 1.78(1.51–2.09) 0.00 50 1.00(0.56–1.80) 0.68 0
Haplotype group
 Ancient and spitz 1.07(0.64–1.76) 0.64 0 1.30(.077–2.19) 0.41 3 2.00(1.41–2.84) 0.00 50 0.97(0.75–1.27) 0.64 0 1.24(0.47–3.21) 0.59 0
 Herding 0.71(0.42–1.20) 0.26 3 1.97(1.32–2.92) 0.00 49 1.30(0.93–1.79) 0.18 16 1.01(0.82–1.25) 0.66 0 1.06(0.56–2.00) 0.64 0
 Mastiff-like 1.17(0.80–1.72) 0.46 2 1.15(0.75–1.78) 0.48 1 1.21(0.86–1.71) 0.37 6 1.21(0.99–1.48) 1.10 23 0.81(0.46–1.43) 48 0
 Retriever 3.24(2.60–4.03) 0.00 50 1.21(0.90–1.63) 0.25 5 1.62(1.32–1.99) 0.00 50 1.11(0.96–1.29) 0.25 12 1.41(0.85–2.35) 0.25 4
 Scent hound 1.00(0.40–2.49) 0.65 0 1.99(1.22–3.25) 0.02 45 1.61(1.05–2.47) 0.06 28 6.33(5.22–7.68) 0.00 50 1.04(0.57–1.87) 0.68 0
 Sight hound 0.15(0.02–1.13) 0.08 17 1.51(0.59–3.88) 0.45 2 1.11(0.51–2.42) 0.62 0 1.39(0.91–2.13) 0.20 9 1.89(0.55–6.58) 0.36 0
 Small terrier 0.28(0.02–3.66) 0.44 1 0.93(0.48–1.79) 0.62 0 1.23(0.70–2.17) 0.51 2 0.51(0.38–0.70) 0.00 50 6.90(4.36–10.93) 0.00 50
 Spaniel 0.57(0.29–1.11) 0.15 16 1.81(1.20–2.73) 0.02 46 1.76(1.27–2.43) 0.01 49 0.88(0.71–1.09) 0.28 2 0.76(0.40–1.55) 0.48 0
 Toy 0.40(0.6–2.80) 0.37 0 1.42(0.89–2.26) 0.22 14 1.22(0.77–1.93) 0.44 4 1.24(1.51) 0.07 32 2.92(1.95–4.38) 0.00 50
 Working group 1 0.30(0.08–1.06) 0.09 22 2.54(1.40–4.61) 0.01 48 1.26(0.72–2.20) 0.47 2 1.19(0.88–1.61) 0.33 3 2.23(1.14–4.37) 0.05 35
 Working group 2 1.88(1.35–2.30) 0.00 50 1.40(0.91–2.15) 0.20 10 1.49(1.09–2.02) 0.04 40 2.51(2.07–3.03) 0.00 50 0.74(0.29–1.88) 0.53 0