The effect of genetic bottlenecks and inbreeding on the incidence of two major autoimmune diseases in standard poodles, sebaceous adenitis and Addison’s disease

Pedersen, Niels C.; Brucker, Lynn; Tessier, Natalie Green; Liu, Hongwei; Penedo, Maria Cecilia T.; Hughes, Shayne; Oberbauer, Anita; Sacks, Ben

doi:10.1186/s40575-015-0026-5

Canine Medicine and Genetics

Table 3 DLA STR-based class I and II haplotypes and their frequencies in standard poodles (n = 673), Miniature Poodles (n = 16), and miniature/standard poodle crosses (72)

From: The effect of genetic bottlenecks and inbreeding on the incidence of two major autoimmune diseases in standard poodles, sebaceous adenitis and Addison’s disease

Class I			Class II
ID	Haplotype	Frequency	ID	Haplotype	Frequency	DLA-DRB1/DQA1/DQB1
1001	380/373/281/182	0.259	2001	343/324/284	0.605	01501/00601/02301
1002	380/365/281/181	0.200	2002	343/327/280	0.091	01501/00901/00101
1003	387/375/277/186	0.157	2003	343/324/282	0.092	01503/00601/02301
1004	393/379/277/183	0.090	2004	351/327/268	0.027	02001/00401/01303
1005	389/371/277/181	0.056	2005^b	339/322/280	0.024	00101/00101/00201
						00901/00101/008011
1006	387/375/293/180	0.043	2006	339/325/280	0.032	01502/00601/02301
1007	380/372/281/182	0.031	2007	351/327/280	0.016	02001/00401/01303
1008	386/373/289/182	0.018	2008	339/327/276	0.011	00101/00101/03601
1009	382/377/277/184	0.011	2009	351/324/280	0.016
1010	384/371/277/186	0.016	2010	345/329/280	0.016	01201/00401/013017
1011	376/365/281/180	0.020	2011^c	345/322/284	0.020	00901/00101/008011
1012	388/369/289/188	0.011	2012^c	345/322/280	0.008	00901/00101/008011
1013	392/373/289/186	0.010	2013	345/327/284	0.008	00201/00901/00101
1014	375/373/287/178	0.008	2014	339/322/284	0.005
1015	380/373/291/186	0.003	2015^a	339/327/280	0.005
1016	382/371/277/178	0.005	2016^c	339/323/284	0.003	00601/05011/00701
1017	386/373/289/178	0.005	2017	343/322/280	0.004
1018^a	375/373/287/186	0.013	2018^c	339/324/284	0.001	00601/05011/00701
1019	380/373/287/185	0.003	2019	345/324/284	0.001
1020^a	388/369/289/184	0.004	2020	349/324/284	0.001
1021	380/373/289/186	0.003	2021^a	339/324/268	0.001
1022	380/375/281/181	0.001	2022	339/327/282	0.001
1023	380/379/281/181	0.001	2023	341/323/282	0.006
1024	387/373/281/182	0.001	2024^a	343/323/280	0.001
1026	390/369/289/186	0.001	2025^a	351/321/280	0.002
1027	391/371/277/181	0.001	2026	351/324/284	0.001
1028^a	376/369/291/186	0.001	2027	343/325/284	0.001
1029	380/365/281/182	0.003	2028^a	345/327/288	0.001
1030	380/373/293/178	0.006
1031^a	382/371/277/186	0.003
1032^a	382/377/277/178	0.001
1033^a	382/379/277/181	0.001
1034^a	382/379/277/182	0.001
1035	386/373/277/184	0.001
1036^a	389/365/289/180	0.002
1039	379/364/281/181	0.001
1040^a	380/371/277/186	0.001
1041	386/374/277/186	0.001
1042	389/375/293/186	0.001
1043	393/381/277/183	0.001
1045	376/371/277/186	0.001
1046	376/379/291/180	0.001
1057	387/376/277/186	0.001

^aAssociated with Miniature Poodles
^bSingle STR haplotype associated with two known exon 2 sequence based haplotypes
^cTwo different STR haplotypes associated with the same exon 2 sequence based haplotype

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ISSN: 2662-9380

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