The effect of genetic bottlenecks and inbreeding on the incidence of two major autoimmune diseases in standard poodles, sebaceous adenitis and Addison’s disease

Table 7 The average contribution of MCB, Wycliffe, and OEA ancestry to standard poodles during the decades of the 1950s and into the 2010s

Decade	Disease	# Dogs	% MCB	% Wycliffe	% OEA	AvgCOI-10	AvgCOI-15
1950	AD	0	0.0	0.0	0.0	0.0	0.0
1950	SA	0	0.0	0.0	0.0	0.0	0.0
1950	Total population	7,371	4.6	2.0	0.5	9.2	9.6
1960	AD	0	0.0	0.0	0.0	0.0	0.0
1960	SA	12	69.1	61.6	0.0	16.3	17.7
1960	Total population	9,541	18.5	13.0	5.1	11.6	12.7
1970	AD	4	84.8	79.6	0.0	24.5	27.4
1970	SA	17	76.3	70.3	0.0	23.2	26.1
1970	Total population	16,541	37.7	30.8	6.9	12.9	15.3
1980	AD	34	69.8	59.2	2.7	20.6	24.9
1980	SA	142	70.8	62.6	0.8	22.1	26.2
1980	Total population	25,549	52.7	44.5	6.0	15.1	19.0
1990	AD	209	57.7	49.2	7.0	14.2	19.4
1990	SA	204	61.4	52.8	4.3	15.7	20.9
1990	Total population	48,080	55.5	46.8	6.2	13.5	18.6
2000	AD	316	55.6	47.3	7.4	10.8	17.0
2000	SA	149	60.1	50.3	3.6	11.2	17.9
2000	Total population	71937	53.9	45.1	7.0	9.4	15.6
2010	AD	23	53.0	44.7	8.5	6.8	13.7
2010	SA	11	58.3	49.2	5.4	11.6	19.0
2010	Total population	24378	51.7	43.4	8.3	6.6	13.4

The % MCB, % Wycliffe and % OEA were calculated from the Standard Poodle Database during each decade as well as for dogs known to have had SA and AD. The average COI over 10 and 15 generations were also determined for dogs born in each decade. Data on SA and AD represent cases voluntarily reported to the Standard Poodle health registry database [25] and not actual incidence. Data for the 2010s were only through 2014

ISSN: 2662-9380