Fig. 2
From: A cultured approach to canine urothelial carcinoma: molecular characterization of five cell lines
The cell lines demonstrate evidence of chromothriptic-like events in tumor evolution. Chromothriptic-like events were seen throughout the genomes of all five cell lines, involving all but six chromosomes (a). The maximum average number of events on a single chromosome was observed on CFA10, with ten chromothriptic-like events. CFA2, 5, 19, 20, 35, and 36 all showed an average of over four events (b). At least three of the cell lines displayed chromothriptic-like events on CFA2, 5, 7, 9, 10, 18, 20, 27 and X. Thus, complex chromothriptic-like activity is a common event in the UC cell lines, just as in primary tumors