Fig. 3
From: A cultured approach to canine urothelial carcinoma: molecular characterization of five cell lines
Structural Aberrations exist in oaCGH-flagged Regions. Tandem duplications, translocations, and fusions were noted throughout the karyotypes. According to oaCGH, CFA 10 (BAC probe CHORI-82:326H08; Cy5-labeled) shows a sharp spike of gain in the probed region (MDM2). FISH shows this spike might be attributed to tandem duplications of the locus along the chromosome (a). CFA 13 (BAC probe CHORI-82:BAC 186J06; Aqua-labeled) appears as two fused copies (b) multiple times within a karyotype, in addition to what appear to be normal copies, leading to an overall gain. Tandem duplication and locus translocation are both observed on chromosomes 36 (BAC probe CHORI-82:199F16, Cy5-labeled)/38 (BAC probe CHORI-82:328D10, Gold-labeled) (c). The pattern shows an overlap of duplication, in which a copy of the CFA 36 locus is flanked by CFA 38