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Table 4 Human lumbar spinal stenosis candidate genes and location in canine genome

From: Lumbosacral stenosis in Labrador retriever military working dogs – an exomic exploratory study

Human LSS Candidate genes

Human Musculo-skeletal diseases associated with Human LSS

Homo sapiens Chromosome number

Canis familiaris Chromosome number

Canine gene NCBI Gene ID

Canine Gene Validation Status

COL1A1

LSS

17

CF 9

403,651

Provisional

COL1A2

LSS, OI, EDS

7

CF 14

403,824

Provisional

COL2A1

OA, LSS

12

CF 27

403,826

Provisional

COL9A1

OA, LSS

6

CF 12

481,873

Model

COL9A2

OA, LSS, DDD

1

CF 15

607,609

Validated

COL9A3

OA, LSS, DDD

20

CF 24

612,430

Validated

COL11A1

OA, LSS

1

CF 6

100,685,969

Model

COL11A2

OA, LSS, DDD, OPLL

6

CF 12

481,734

Model

VDR

DDD, LSS

12

CF 27

486,588

Model

MMP-3

DDD, LSS

11

CF 5

403,445

Provisional

  1. List of human LSS candidate genes, based on previous studies. Also listed are the human diseases associated with human LSS, human gene chromosome number, chromosome number of the canine orthologue, NCBI gene ID and validation status of the canine gene
  2. Legend: CF canis familiaris, LSS lumbar spinal stenosis, OA osteoarthritis, EDS Ehlers-Danlos syndrome, OPLL ossification of posterior longitudinal ligament, OI osteogenesis imperfecta, DDD degenerative disc disease, COL(x)A(y) collagen type (x) alpha (y), MMP-3 matrix metallo-peptidase 3, VDR vitamin D receptor