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Table 1 Number and genotype frequency of tested MWHDs and estimation of the mutation allele frequency

From: Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom

  Number of dogs Genotype frequency (%) Mutation allele frequency
Total Clear Carrier Homozygous Clear Carrier Homozygous
Total 733 448 234 51 61.1 31.9 7.0 0.2
Australia 17 16 1 0 94.1 5.9 0 0.03
Europea 604 363 202 39 60.1 33.4 6.5 0.2
UK only 548 316 193 39 57.7 35.2 7.1 0.2
North-America 61 40 17 4 65.6 27.9 6.6 0.2
  1. aincluding UK
  2. A total of 733 MWHDs were DNA tested in this study. Within the tested dogs 7.0% were homozygous for the NHLRC1 mutation and at risk for LD and 31.9% of the tested dogs carries the mutation. Similar frequencies were observed among the European population, including dogs of UK origin and in the dataset of dogs originating from UK only. Only small cohorts originated from Australia and North-America