Skip to main content

Table 1 Number and genotype frequency of tested MWHDs and estimation of the mutation allele frequency

From: Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom

 

Number of dogs

Genotype frequency (%)

Mutation allele frequency

Total

Clear

Carrier

Homozygous

Clear

Carrier

Homozygous

Total

733

448

234

51

61.1

31.9

7.0

0.2

Australia

17

16

1

0

94.1

5.9

0

0.03

Europea

604

363

202

39

60.1

33.4

6.5

0.2

UK only

548

316

193

39

57.7

35.2

7.1

0.2

North-America

61

40

17

4

65.6

27.9

6.6

0.2

  1. aincluding UK
  2. A total of 733 MWHDs were DNA tested in this study. Within the tested dogs 7.0% were homozygous for the NHLRC1 mutation and at risk for LD and 31.9% of the tested dogs carries the mutation. Similar frequencies were observed among the European population, including dogs of UK origin and in the dataset of dogs originating from UK only. Only small cohorts originated from Australia and North-America