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Table 4 Yearly number and genotype frequency of the tested MWHDs

From: Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom

 

Genotype frequency (%)

Year

2012

2013

2014

2015

2016

2017

Clear

70.6

48.1

61.6

68.8

65.1

71.6

Carrier

23.5

41.5

31.5

25.4

29.5

25.7

Homozygous

5.9

10.4

6.8

5.8

5.4

2.7

Total no. of dogs

34

212

146

138

129

74

  1. LD DNA test was developed in 2012 and after initial validation of the test in a small cohort of MWHDs the test has been offered since 2013. After a few years of genetic testing a decrease in the frequency of homozygous and carrier dogs can be observed and as a consequence the frequency of clear dogs has increased over the years. The slow decrease indicates that carrier dogs are kept as part of the breeding program to avoid compromising the genetic diversity of MWHDs