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Table 4 Yearly number and genotype frequency of the tested MWHDs

From: Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom

  Genotype frequency (%)
Year 2012 2013 2014 2015 2016 2017
Clear 70.6 48.1 61.6 68.8 65.1 71.6
Carrier 23.5 41.5 31.5 25.4 29.5 25.7
Homozygous 5.9 10.4 6.8 5.8 5.4 2.7
Total no. of dogs 34 212 146 138 129 74
  1. LD DNA test was developed in 2012 and after initial validation of the test in a small cohort of MWHDs the test has been offered since 2013. After a few years of genetic testing a decrease in the frequency of homozygous and carrier dogs can be observed and as a consequence the frequency of clear dogs has increased over the years. The slow decrease indicates that carrier dogs are kept as part of the breeding program to avoid compromising the genetic diversity of MWHDs