Heterozygosity testing and multiplex DNA panel screening as a potential tool to monitor health and inbreeding in a small, closed dog population

Table 1 Individual determination of genotype and coagulation profile in the Dutch Shepherd Dog

Dog #	Genotype	VWF	Thrombocytes	Fibrinogen
1	G/G	7	344	1.6
2	G/G	18	257	1.6
3	G/G	30	344	1.8
4	G/G	33	322	1.8
5	G/G	37	97*	4.2*
6	G/G	62	342	1.4
7	G/G	65	338	1.8
8	G/G	77	358	1.6
9	G/G	95	395	3.2
10	G/A	9	284	1.8
11	G/A	10	305	1.7
12	G/A	11	366	2
13	G/A	12	381	2.1
14	G/A	26	247	1.1
15	G/A	31	330	2
16	G/A	31	334	1.9
17	G/A	34	360	1.9
18	A/A	10	321	3.7
19	A/A	15	303	1.6

Results for Von Willebrand’s Factor protein concentrations in blood, Von Willebrand’s Disease genotype (G/G = wildtype, G/A = heterozygous carrier, A/A = homozygous mutant), thrombocytes (ref. 144–603 10⁹/L) and fibrinogen (ref. 1.0–2.7 g/L) in 19 Dutch Shepherd Dogs. *Many thrombocyte aggregates present

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