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Table 1 Published three-locus DLA class II haplotypes associated with increased risk for some immune-related diseases in dogs

From: DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

Disease DLA-DRB1 DLA-DQA1 DLA-DQB1 Breed(s) Reference
AD 009:01 001:01 008:02 Bearded collie Massey et al. 2013 [3]
009:01 001:01 008:01:1 Cocker spaniel
015:01 006:01 023:01 Cocker spaniel, Springer spaniel
001:01 002:01 013:03 Springer spaniel
001:01 001:01 002:01 Labrador retriever, WHWT
015:02 006:01 023:01 Standard poodle
015:02 006:01 023:01 NSDTR Hughes et al. 2010 [38]
SLO 018:01 001:01 008:02 Bearded collie, Gordon setter Wilbe et al. 2010; Ziener et al. 2015 [24, 43]
018:01 001:01 002:01 Bearded collie Wilbe et al. 2010; Dahlgren et al. 2016 [24, 28]
001:01 001:01 002:01 Giant schnauzer, English setter
101:02a 001:01 002:01 English setter Dahlgren et al. 2016 [28]
Hypothyroidism 012:01 001:01 002:01 Doberman pinscher, Giant schnauzer Kennedy et al. 2006; Wilbe et al. 2010 [40, 44]
001:07 001:01 002:01 English setter Ziener et al. 2015 [43]
001:03 001:01 002:01 Gordon setter
001:01 001:01 002:01
049:01 010:01 019:01
Diabetes mellitus 009 001 008 Multiple breeds Kennedy et al. 2006 [39]
015 006 023
002 009 001
Hepatitis 006:01 004:01 013:03 Doberman pinscher Dyggve et al. 2011 [36]
Anal furunculosis 001:01 001:01 002:01 German shepherd Kennedy et al. 2008 [42]
Necrotizing meningoencephalitis 010:01:1 002:01 015:01 Pug Greer et al. 2010 [37]
Meningoencephalitis 018:02 001:01 008:02 Greyhound Shiel et al. 2014 [45]
015:01 006:01 022:01
  1. AD Addison’s disease, SLO symmetrical lupoid onychodystrophy, NSDTR Nova Scotia duck tolling retriever, WHWT West Highland white terrier
  2. aCurrent nomenclature is 001:07