DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

Table 1 Published three-locus DLA class II haplotypes associated with increased risk for some immune-related diseases in dogs

Disease	DLA-DRB1	DLA-DQA1	DLA-DQB1	Breed(s)	Reference
AD	009:01	001:01	008:02	Bearded collie	Massey et al. 2013 [3]
	009:01	001:01	008:01:1	Cocker spaniel
	015:01	006:01	023:01	Cocker spaniel, Springer spaniel
	001:01	002:01	013:03	Springer spaniel
	001:01	001:01	002:01	Labrador retriever, WHWT
	015:02	006:01	023:01	Standard poodle
	015:02	006:01	023:01	NSDTR	Hughes et al. 2010 [38]
SLO	018:01	001:01	008:02	Bearded collie, Gordon setter	Wilbe et al. 2010; Ziener et al. 2015 [24, 43]
	018:01	001:01	002:01	Bearded collie	Wilbe et al. 2010; Dahlgren et al. 2016 [24, 28]
	001:01	001:01	002:01	Giant schnauzer, English setter	Wilbe et al. 2010; Dahlgren et al. 2016 [24, 28]
	101:02^a	001:01	002:01	English setter	Dahlgren et al. 2016 [28]
Hypothyroidism	012:01	001:01	002:01	Doberman pinscher, Giant schnauzer	Kennedy et al. 2006; Wilbe et al. 2010 [40, 44]
	001:07	001:01	002:01	English setter	Ziener et al. 2015 [43]
	001:03	001:01	002:01	Gordon setter
	001:01	001:01	002:01
	049:01	010:01	019:01
Diabetes mellitus	009	001	008	Multiple breeds	Kennedy et al. 2006 [39]
	015	006	023
	002	009	001
Hepatitis	006:01	004:01	013:03	Doberman pinscher	Dyggve et al. 2011 [36]
Anal furunculosis	001:01	001:01	002:01	German shepherd	Kennedy et al. 2008 [42]
Necrotizing meningoencephalitis	010:01:1	002:01	015:01	Pug	Greer et al. 2010 [37]
Meningoencephalitis	018:02	001:01	008:02	Greyhound	Shiel et al. 2014 [45]
Meningoencephalitis	015:01	006:01	022:01	Greyhound	Shiel et al. 2014 [45]

AD Addison’s disease, SLO symmetrical lupoid onychodystrophy, NSDTR Nova Scotia duck tolling retriever, WHWT West Highland white terrier
^aCurrent nomenclature is 001:07

ISSN: 2662-9380