Skip to main content

Table 2 Frequency, code, and odds ratio (OR) with 95% confidence interval (CI) of each three-locus haplotype observed in healthy, Addisonian (AD) and symmetrical lupoid onychodystrophy (SLO) bearded collies

From: DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

Code Haplotype Controls AD SLO
  DLA-DRB1/DQA1/DQB1 2n = 244 % 2n = 122 % OR (95%CI) p-value 2n = 100 % OR (95%CI) p-value
1 009:01/001:01/008:02 24 9.8 25 20.5 2.36 (1.29–4.34) 0.0058 1 1.0 0.09 (0.01–0.70) 0.0047
2 015:01/006:01/003:01 31 12.7 18 14.8 1.19 (0.64–2.22) 0.6263 4 4.0 0.29 (0.10–0.83) 0.0172
3 015:01/006:01/023:01 33 13.6 23 18.9 1.49 (0.83–2.66) 0.2177 2 2.0 0.13 (0.03–0.55) 0.0013
4 018:01/001:01/002:01 73 29.9 27 22.1 0.67 (0.40–1.11) 0.1355 47 47.0 2.08 (1.29–3.35) 0.0029
5 018:01/001:01/008:02 70 28.7 27 22.1 0.71 (0.42–1.18) 0.2094 46 46.0 2.12 (1.31–3.43) 0.0026
6 015:01/006:01/022:01 5 2.0 2 1.6 0.80 (0.15–4.17) 1 0 0.0 N/A  
7 002:01/009:01/001:01 6 2.5 0 0.0 N/A   0 0.0 N/A  
8 023:01/003:01/005:01 1 0.4 0 0.0 N/A   0 0.0 N/A  
9 015:02/006:01/023:01 1 0.4 0 0.0 N/A   0 0.0 N/A  
  1. N/A not enough data points to calculate; Fisher’s exact p-value
  2. Text in bold indicates the haplotype frequency significantly differed between cases and controls