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Table 2 Frequency, code, and odds ratio (OR) with 95% confidence interval (CI) of each three-locus haplotype observed in healthy, Addisonian (AD) and symmetrical lupoid onychodystrophy (SLO) bearded collies

From: DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

Code

Haplotype

Controls

AD

SLO

 

DLA-DRB1/DQA1/DQB1

2n = 244

%

2n = 122

%

OR (95%CI)

p-value†

2n = 100

%

OR (95%CI)

p-value†

1

009:01/001:01/008:02

24

9.8

25

20.5

2.36 (1.29–4.34)

0.0058

1

1.0

0.09 (0.01–0.70)

0.0047

2

015:01/006:01/003:01

31

12.7

18

14.8

1.19 (0.64–2.22)

0.6263

4

4.0

0.29 (0.10–0.83)

0.0172

3

015:01/006:01/023:01

33

13.6

23

18.9

1.49 (0.83–2.66)

0.2177

2

2.0

0.13 (0.03–0.55)

0.0013

4

018:01/001:01/002:01

73

29.9

27

22.1

0.67 (0.40–1.11)

0.1355

47

47.0

2.08 (1.29–3.35)

0.0029

5

018:01/001:01/008:02

70

28.7

27

22.1

0.71 (0.42–1.18)

0.2094

46

46.0

2.12 (1.31–3.43)

0.0026

6

015:01/006:01/022:01

5

2.0

2

1.6

0.80 (0.15–4.17)

1

0

0.0

N/A

 

7

002:01/009:01/001:01

6

2.5

0

0.0

N/A

 

0

0.0

N/A

 

8

023:01/003:01/005:01

1

0.4

0

0.0

N/A

 

0

0.0

N/A

 

9

015:02/006:01/023:01

1

0.4

0

0.0

N/A

 

0

0.0

N/A

 
  1. N/A not enough data points to calculate; †Fisher’s exact p-value
  2. Text in bold indicates the haplotype frequency significantly differed between cases and controls
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Canine Medicine and Genetics

ISSN: 2662-9380