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Table 3 DLA class II genotypes significantly associated with Addison’s disease (AD) and symmetrical lupoid onychodystrophy (SLO) in 233 Bearded collies, and corresponding odds ratios (OR) with the 95% confidence interval (CI) using the DLA haplotype codes reported in Table 2

From: DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

Disease Genotypes Controls Cases p-value† OR (95% CI)
   n % n %   
AD All genotypes containing haplotype 1 23 18.9 23 37.7 0.0070 2.6 (1.31–5.19)
AD Genotype 1 5 7 5.7 11 18.0 0.0154 3.6 (1.32–9.87)
SLO All genotypes containing haplotype 4 62 50.8 36 72.0 0.0115 2.5 (1.22–5.07)
SLO All genotypes containing haplotype 5 59 48.4 35 70.0 0.0114 2.5 (1.24–5.02)
SLO Genotype 4 4 11 9.0 11 22.0 0.0258 2.8 (1.14–7.08)
SLO Genotype 5 5 11 9.0 11 22.0 0.0258 2.8 (1.14–7.08)
SLO Genotype 4 5 23 18.9 22 44.0 0.0011 3.4 (1.65–6.94)
SLO Genotypes containing haplotypes 4 and/or 5 98 80.3 49 98.0 0.0033 12.0 (1.58–91.33)
  1. †Fisher’s exact p-value, significant at p < 0.05
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Canine Medicine and Genetics

ISSN: 2662-9380

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