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Table 1 Distribution of study dogs based on breed status and genotype

From: vWDI is inherited in an autosomal dominant manner with incomplete penetrance, in the Kromfohrländer breed

  WT/WT WT/MUT MUT/MUT Total
Purebred 14.9% 47.1% 11.5% 73.5%
F1 offspring 1.2% 1.2% 0.0% 2.4%
F2 offspring 2.3% 13.7% 2.3% 18.3%
F3 offspring 1.2% 3.4% 1.2% 5.8%
  1. Purebred Kromfohrländer as well as different offspring generations from a cross breeding program with Dansk-Svensk Gårdshund (Danish–Swedish Farmdog) where included in this study. The distribution based on the breed status and the corresponding genotype (wild-type (WT/WT), heterozygous (WT/MUT), homozygous (MUT/MUT)) is shown in this table. With 73.5% most study dogs where purebred Kromfohrländer followed by 18.3% F2 offspring. Genotype distribution shows a clear shift to heterozygotes (WT/MUT) within all 4 breed states