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Table 1 Distribution of study dogs based on breed status and genotype

From: vWDI is inherited in an autosomal dominant manner with incomplete penetrance, in the Kromfohrländer breed

 

WT/WT

WT/MUT

MUT/MUT

Total

Purebred

14.9%

47.1%

11.5%

73.5%

F1 offspring

1.2%

1.2%

0.0%

2.4%

F2 offspring

2.3%

13.7%

2.3%

18.3%

F3 offspring

1.2%

3.4%

1.2%

5.8%

  1. Purebred Kromfohrländer as well as different offspring generations from a cross breeding program with Dansk-Svensk Gårdshund (Danish–Swedish Farmdog) where included in this study. The distribution based on the breed status and the corresponding genotype (wild-type (WT/WT), heterozygous (WT/MUT), homozygous (MUT/MUT)) is shown in this table. With 73.5% most study dogs where purebred Kromfohrländer followed by 18.3% F2 offspring. Genotype distribution shows a clear shift to heterozygotes (WT/MUT) within all 4 breed states