TY - JOUR AU - Lewis, T. W. PY - 2019 DA - 2019/07/19 TI - The impact of incorrectly recorded parentage on inferred genotypes over multiple generations JO - Canine Genetics and Epidemiology SP - 6 VL - 6 IS - 1 AB - The absence of selective pressure against recessive deleterious mutations in the heterozygous state means that virtually every individual will carry several such mutations which have arisen over time. The inflation in frequency of a few of these mutations due to selective processes during domestication and breed formation have left modern domestic dog breeds with a high burden of genetic disease due to mutations at single genes. This has stimulated research into the causal mutations, and a consequential market in DNA tests, which enable breeders to distinguish heterozygotes from wild type homozygotes and determine pairings that will avoid producing diseased progeny. The genotypes of progeny of parents with known genotypes themselves may in some cases be definitively inferred. Importantly, two parents homozygous for non-disease causing alleles, will produce progeny with the same genotype, which may be assigned to the offspring (e.g. as ‘hereditary clear’) without the need for further testing. SN - 2052-6687 UR - https://doi.org/10.1186/s40575-019-0074-3 DO - 10.1186/s40575-019-0074-3 ID - Lewis2019 ER -