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Table 6 Disease-associated genes in the consensus ROHs. Disease and disease candidate genes that are located in the consensus ROHs of the Dalmatians are depicted. Other genes that are located in the 13 consensus ROH are also given. The start and end of consensus ROHs in base pairs and the length of consensus ROH in base pairs comply to the detection of consensus ROH with the 10 SNP threshold

From: Demographic assessment of the Dalmatian dog – effective population size, linkage disequilibrium and inbreeding coefficients

Chromosome

Start (bp)

End (bp)

Length of consensus ROH in beadchip SNPs

Length of consensus ROH in bp

Genes that are located in the consensus ROH

Associated diseases of those genes

1

23,754,226

24,443,343

55

689.117

MEX3C, SMAD4, ELAC1, ME2, MRO, RF00001, MC2R, MC5R, ENSCAFG00000032822

Glaucoma (SMAD4), Idiopathic epilepsy (ME2)

3

67,712,997

67,855,181

13

142.184

ENSCAFG00000033564, ENSCAFG00000036945, ENSCAFG00000037957

3

67,876,487

68,200,003

29

323.516

ENSCAFG00000033306, ENSCAFG00000033607

3

69,068,007

69,485,604

38

417.597

CLNK, ZNF518B, SLC2A9, WDR1, ENSCAFG00000039826, ENSCAFG00000033935

Diabetes mellitus, entropion, hyperuricosuria (SLC2A9)

4

38,457,632

38,587,643

15

130.011

NSG2, ENSCAFG00000032093

13

3,182,619

3,330,775

13

148.156

GRHL2, ENSCAFG00000030800

Deafness (GRHL2)

13

3,490,088

3,550,490

7

60.402

ENSCAFG00000036103

17

35,638,035

35,834,516

17

196.481

BCL2L11, ENSCAFG00000036821, ENSCAFG00000007091

Deafness (BCL2L11)

17

35,861,411

35,861,411

1

1

ENSCAFG00000035515, ENSCAFG00000040340

17

39,631,741

39,800,897

18

169.156

CAPG, ELMOD3, RETSAT, TCF7L1, ENSCAFG00000024531

Deafness (ELMOD3)

24

15,945,228

16,028,176

7

82.948

SHLD1

24

34,585,142

34,731,796

12

146.654

NCOA3, ENSCAFG00000035729, ENSCAFG00000010850

38

11,140,991

11,561,386

36

420.395

USH2A

Deafness