Table 3 Odds Ratios (OR) and 95% confidence intervals (CI) for genotypes of the 3-SNP CFA 14 haplotype and the 2-SNP CFA 37 haplotype associated with idiopathic epilepsy. Not applicable (NA) reflects the inability to calculate the OR. The genotype associated with elevated risk for Belgian shepherds is indicated with an asterisk
From: Genome-wide association analysis of idiopathic epilepsy in the Belgian shepherd
Genotype for the significant CFA 14 SNPs BICF2P1043850/BICF2S23749130/TIGRP2P191770_rs9025240 | Controls (n = 62) | Cases (n = 35) | OR (95% CI) | p value |
AA/AA/AA | 46 | 9 | 0.12 (0.05–0.31) | 0.000005 |
AG/AG/AC* | 16 | 23 | 5.51 (2.24–13.56) | 0.000201 |
GG/GG/CC | 0 | 3 | NA | 0.044391 |
AA/AA/AA vs GG/GG/CC | 46 | 9 | NA | 0.007130 |
0 | 3 | |||
AA/AA/AA vs AG/AG/AC* | 46 | 9 | 0.14 (0.05–0.35) | 0.000024 |
16 | 23 | |||
AG/AG/AC vs GG/GG/CC | 16 | 23 | NA | 0.275261 |
0 | 3 | |||
Genotypes for the suggestive CFA 37 SNPs BICF2P271491/TIGRP2P419463_rs8724220 | Controls (n = 62) | Cases (n = 35) | OR (95% CI) | p value |
AA/AA | 12 | 1 | 0.12 (0.02–0.99) | 0.028124 |
AG/AG | 25 | 6 | 0.31 (0.11–0.84) | 0.023494 |
GG/GG* | 25 | 28 | 5.92 (2.24–15.62) | 0.000249 |
AA/AA vs GG/GG* | 12 | 1 | 0.07 (0.01–0.61) | 0.004025 |
25 | 28 | |||
AA/AA vs AG/AG | 12 | 1 | 0.35 (0.04–3.22) | 0.419318 |
25 | 6 | |||
AG/AG vs GG/GG* | 25 | 6 | 0.21 (0.08–0.61) | 0.002890 |
25 | 28 |