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Table 4 Odds Ratio for the significant haplotype blocks on CFA 14 and 37. The CanFam3.1 reference allele is indicated in bold and haplotypes associated with significantly elevated risk for idiopathic epilepsy in Belgian shepherds are indicated with an asterisk

From: Genome-wide association analysis of idiopathic epilepsy in the Belgian shepherd

CFA 14 Haplotype Blocka

Haplotype

Controls (2n = 88)

Cases (2n = 38)

OR (95% CI)

p value

BICF2S23230472

BICF2P437468

BICF2S23211419

BICF2S23539344

CTCT

67

14

0.18 (0.08–0.42)

0.00004

vs. CTCG, ACTG

21

24

  

CTCG

14

9

1.64 (0.64–4.20)

0.321651

vs. CTCT, ACTG

74

29

  

ACTG*

7

15

7.55 (2.75–20.71)

0.000054

vs. CTCT, CTCG

81

23

  

CFA 37 Haplotype Block

Haplotype

Controls (2n = 90)

Cases (2n = 40)

OR (95% CI)

p value

BICF2P1290526

BICF2P1131874

BICF2P890779

BICF2P434501

TIGRP2P419329_rs9085363

BICF2P426309

TAGCTC

43

4

0.12 (0.04–0.37)

0.000057

vs. TGACTC, CGATTC, CGATGT

47

36

  

TGACTC

24

16

1.83 (0.84–4.03)

0.151538

vs TAGCTC, CGATTC, CGATGT

66

24

  

CGATTC*

10

13

3.85 (1.52–9.79)

0.00548

vs. TAGCTC, TGACTC, CGATGT

80

27

  

CGATGT

13

7

1.26 (0.46–3.43)

0.7927

vs. TAGCTC, TGACTC, CGATTC

77

33

  
  1. a genotype for BICF2S23230472 was unable to be determined for one case and one control dog