Skip to main content

Table 4 Odds Ratio for the significant haplotype blocks on CFA 14 and 37. The CanFam3.1 reference allele is indicated in bold and haplotypes associated with significantly elevated risk for idiopathic epilepsy in Belgian shepherds are indicated with an asterisk

From: Genome-wide association analysis of idiopathic epilepsy in the Belgian shepherd

CFA 14 Haplotype Blocka Haplotype Controls (2n = 88) Cases (2n = 38) OR (95% CI) p value
BICF2S23230472
BICF2P437468
BICF2S23211419
BICF2S23539344
CTCT 67 14 0.18 (0.08–0.42) 0.00004
vs. CTCG, ACTG 21 24   
CTCG 14 9 1.64 (0.64–4.20) 0.321651
vs. CTCT, ACTG 74 29   
ACTG* 7 15 7.55 (2.75–20.71) 0.000054
vs. CTCT, CTCG 81 23   
CFA 37 Haplotype Block Haplotype Controls (2n = 90) Cases (2n = 40) OR (95% CI) p value
BICF2P1290526
BICF2P1131874
BICF2P890779
BICF2P434501
TIGRP2P419329_rs9085363
BICF2P426309
TAGCTC 43 4 0.12 (0.04–0.37) 0.000057
vs. TGACTC, CGATTC, CGATGT 47 36   
TGACTC 24 16 1.83 (0.84–4.03) 0.151538
vs TAGCTC, CGATTC, CGATGT 66 24   
CGATTC* 10 13 3.85 (1.52–9.79) 0.00548
vs. TAGCTC, TGACTC, CGATGT 80 27   
CGATGT 13 7 1.26 (0.46–3.43) 0.7927
vs. TAGCTC, TGACTC, CGATTC 77 33   
  1. a genotype for BICF2S23230472 was unable to be determined for one case and one control dog