Fig. 1
From: Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism
Canine CTLA4 promoter region variation and selected response elements. Primer binding sites are shown, highlighted yellow with arrow denoting the starting base in a 5′-3′ direction. Variations are as named, indicated by
or
; SNPs highlighted green, Dog Genome Assembly allele followed by variant shown; INDELs highlighted red, capital letters denote a variant present in, and lowercase letters denote variation not present in, the dog genome assembly sequence. Predicted response elements NFAT TTTCC (a) highlighted pink; partial SP1 site highlighted turquoise; partial GATA1 site highlighted blue; predicted AP-1 site highlighted purple; FoxP3 TTTGTT highlighted grey; TCF site highlighted dark green. SNP codes: M: A/C; R: A/G; S: C/G; Y: C/T; K: G/T. Exon sequence is orange. The ATG start codon isbold double underlined.The TATA box isbold single underlined