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Table 6 Association of CTLA4 polymorphisms with hypoadrenocorticism in springer spaniels. Markers are as Table 3, 5′ to 3′ order from top to bottom SNPs and then indels. MAF: minor allele frequency; NaN: not a number; N/A: not calculable; OR: odds ratio; 95% CI: 95% confidence intervals of the OR; Max (T) p value calculated by permutation analysis; FDR: false discovery rate

From: Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism

Marker

Minor allele

MAF in cases

MAF in controls

Max (T)

p value

FDR

OR (95% CI)

SNP1

A

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP2

A

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP3

A

0

0.008

1

1

0 (0 - NaN)

SNP4

A

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP5

A

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP6

A

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP7

G

0.535

0.315

0.008

0.03462

2.5 (1.29–4.82)

SNP8

A

0.035

0

0.132

0.1072

N/A

SNP9

A

0.482

0.298

0.027

0.03462

2.19 (1.13–4.23)

SNP10

G

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP11

N/A

0

0

1

1

N/A

SNP12

T

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP13

T

0.125

0.140

1

1

0.87 (0.33–2.26)

SNP14

C

0.5

0.350

0.071

0.07347

1.85 (0.96–3.54)

SNP15

C

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP16

G

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP17

N/A

0

0

1

1

N/A

SNP18

G

0

0.008

1

1

0 (0 - NaN)

SNP19

A

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

SNP20

N/A

0

0

1

1

N/A

indel1

N/A

0

0

1

1

N/A

indel2

–

0.5

0.315

0.026

0.03462

2.16 (1.12–4.17)

indel3

–

0.375

0.543

0.031

0.0571

0.50 (0.26–0.96)