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Table 7 Association of CTLA4 polymorphisms with hypoadrenocorticism in cocker spaniels. Markers are as Table 1, 5′ to 3′ SNPs then indels top to bottom. MAF: minor allele frequency; NaN: not a number; N/A: not calculable; OR: odds ratio; 95% CI: 95% confidence intervals of the OR. Max (T) p value calculated by permutation analysis; FDR: false discovery rate

From: Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism

MarkerMinor alleleMAF in casesMAF in controlsMax (T)
p value
FDROR (95% CI)
SNP1A0.1580.0590.0820.098873 (0.9–9.9)
SNP2A0.1580.0590.0820.098873 (0.9–9.9)
SNP3A00.0098110 (0 - NaN)
SNP4A0.1580.0590.0820.098873 (0.9–9.9)
SNP5A0.1580.0590.0820.098873 (0.9–9.9)
SNP6A0.1580.0590.0820.098873 (0.9–9.9)
SNP7G0.1580.0590.0820.098873 (0.9–9.9)
SNP8N/A0011N/A
SNP9A00.01961110 (0 - NaN)
SNP10G0.1580.0590.0820.098873 (0.9–9.9)
SNP11N/A0011N/A
SNP12T0.1580.0590.0820.098873 (0.9–9.9)
SNP13T0.1050.00980.0160.0988711.88 (1.2–110)
SNP14C0.1840.0590.0310.098873.61 (1.1–11.5)
SNP15C0.1580.0590.0820.098873 (0.9–9.9)
SNP16G0.1580.0590.0820.098873 (0.9–9.9)
SNP17N/A0011N/A
SNP18N/A0011N/A
SNP19A0.1580.0590.0820.098873 (0.9–9.9)
SNP20N/A0011N/A
indel1N/A0011N/A
indel20.1580.0590.0820.098873 (0.9–9.9)
indel3+0.2630.0670.00970.057834.85 (1.6–13.9)