TY - JOUR AU - Edmunds, Grace L. AU - Smalley, Matthew J. AU - Beck, Sam AU - Errington, Rachel J. AU - Gould, Sara AU - Winter, Helen AU - Brodbelt, Dave C. AU - O’Neill, Dan G. PY - 2021 DA - 2021/03/10 TI - Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study JO - Canine Medicine and Genetics SP - 2 VL - 8 IS - 1 AB - Osteosarcoma is an aggressive and painful bone neoplasm in dogs. Previous studies have reported epidemiological associations suggesting that large body mass, long bone length and the genetics of certain breeds including the Rottweiler are associated with elevated osteosarcoma risk. However, these studies were often limited by selection bias and confounding factors, and have rarely offered insights into breed-associated protection for osteosarcoma. The current study includes 1756 appendicular and axial osteosarcoma cases presenting to VPG Histology (Bristol, UK) compared against a control population of 905,211 dogs without osteosarcoma from primary care electronic patient records in the VetCompass™ dataset. SN - 2662-9380 UR - https://doi.org/10.1186/s40575-021-00100-7 DO - 10.1186/s40575-021-00100-7 ID - Edmunds2021 ER -