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Table 3 Multivariable logistic regression results for breed-related variables significantly associated with diagnosis of osteosarcoma amongst UK dogs

From: Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study

Variable Variable P-value Category OR 95% CI Category P-value
Purebred status < 0.001 Crossbred Base   
   Purebred 1.35 1.18–1.54 < 0.001
   Unrecorded 0.52 0.33–0.79 0.003
KC Breed Group < 0.001 Toy Base   
   Gundog 14.48 9.72–21.58 < 0.001
   Hound 21.54 14.14–32.81 < 0.001
   Not_KC_Recognised 7.10 4.75–10.59 < 0.001
   Pastoral 11.22 7.33–17.15 < 0.001
   Terrier 3.87 2.54–5.90 < 0.001
   Unrecorded 27.39 18.24–41.13 < 0.001
   Utility 2.42 1.49–3.94 < 0.001
Body mass (kg) < 0.001 < 10 Base   
   10–19.9 5.91 4.66–7.50 < 0.001
   20–29.9 7.31 5.75–9.30 < 0.001
   30–39.9 15.82 12.49–20.05 < 0.001
   > 40 18.07 13.87–23.53 < 0.001
   Unrecorded 0.15 0.10–0.22 < 0.001
Dachshund status < 0.001 Non-Dachshund type Base   
   Dachshund type 0.15 0.05–0.46 0.001
   Unrecorded 0.70 0.61–0.79 < 0.001
Spaniel status < 0.001 Non-Spaniel type Base   
   Spaniel type 0.37 0.29–0.47 < 0.001
   Unrecorded 0.65 0.57–0.74 < 0.001
Chondrodystrophy status < 0.001 Non-chondrodystrophic Base   
   Chondrodystrophic 0.13 0.11–0.16 < 0.001
   Unrecorded 0.40 0.36–0.45 < 0.001
Skull shape < 0.001 Mesocephalic Base   
   Brachycephalic 0.39 0.32–0.48 < 0.001
   Dolichocephalic 1.92 1.68–2.19 < 0.001
  1. Legend: Full multivariable logistic regression results for variables significantly associated with diagnosis of osteosarcoma amongst UK dogs. The main model included breed-name as the breed variable (Table 2), and six breed-related variables (purebred-status, Kennel Club breed group, body mass, dachshund-status, spaniel-status, chondrodystrophy status) then replaced breed-name in the model (Table 3). Cases were dogs with osteosarcoma confirmed by analysis of biopsies submitted to VPG Histology between 2008 and 2020 and controls were dogs enrolled in the VetCompass™ database during 2016