Table 2 Select publications detailing proposed mode of inheritance for SAS across various dog breeds
Author | Study | Year | Breed(s) | Mode of Inheritance |
|---|---|---|---|---|
Pyle et al. [5] | The genetics and pathology of discrete subaortic stenosis in the Newfoundland Dog | 1976 | Newfoundland | Polygenic or autosomal dominant |
Stern et al. [26] | Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings | 2012 | Golden Retriever | Inconclusive, suggests autosomal recessive or polygenic inheritance |
Resit-Marti et al. [36] | Genetic evidence of subaortic stenosis in the Newfoundland dog | 2012 | Newfoundland | Autosomal codominant with lethal homozygosity |
Ohad et al. [35] | The occurrence and suspected mode of inheritance of congenital subaortic stenosis and tricuspid valve dysplasia in Dogue de Bordeaux dogs | 2013 | Dogue de Bordeux | Autosomal Recessive |
Stern et al. [23] | A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs | 2014 | Newfoundland | Autosomal Dominant (with incomplete penetrance) or polygenic |
Ontiveros et al. [33] | Congenital Cardiac outflow Tract Abnormalities in dogs: Prevalence and Pattern of Inheritance from 2008 to 2017 | 2019 | • Bullmastiff • Golden Retriever • Rottweiler | Autosomal Recessive |