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Table 2 Select publications detailing proposed mode of inheritance for SAS across various dog breeds

From: Genetics of canine subvalvular aortic stenosis (SAS)

Author Study Year Breed(s) Mode of Inheritance
Pyle et al. [5] The genetics and pathology of discrete subaortic stenosis in the Newfoundland Dog 1976 Newfoundland Polygenic or autosomal dominant
Stern et al. [26] Familial subvalvular aortic stenosis in golden retrievers: inheritance and echocardiographic findings 2012 Golden Retriever Inconclusive, suggests autosomal recessive or polygenic inheritance
Resit-Marti et al. [36] Genetic evidence of subaortic stenosis in the Newfoundland dog 2012 Newfoundland Autosomal codominant with lethal homozygosity
Ohad et al. [35] The occurrence and suspected mode of inheritance of congenital subaortic stenosis and tricuspid valve dysplasia in Dogue de Bordeaux dogs 2013 Dogue de Bordeux Autosomal Recessive
Stern et al. [23] A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs 2014 Newfoundland Autosomal Dominant (with incomplete penetrance) or polygenic
Ontiveros et al. [33] Congenital Cardiac outflow Tract Abnormalities in dogs: Prevalence and Pattern of Inheritance from 2008 to 2017 2019 • Bullmastiff
• Golden Retriever
• Rottweiler
Autosomal Recessive