Study | Parameter | Cut-offs | No./type of cases | Sensitivity % (CI) | Specificity & (CI) |
---|---|---|---|---|---|
Seth et al. 2011 | Lymphocyte count |  > 5.0 × 109/L | 53 HA 110 DMH | 19 (9–32) | 99 (95–100) |
Zeugswetter et al. 2014 | Lymphocyte count |  > 2.45 × 109L | 38 HA 107 DMH | 92 | 91 |
Zeugswetter et al. 2014 | Neutrophil:lymphocyte |  ≤ 2.3 | 38 HA 107 DMH | 67 | 82 |
Zeugswetter et al. 2014 | Eosinophil count |  > 3.98 × 109/L | 38 HA 107 DMH | 91 | 72 |
Seth et al. 2011 | Na:K |  < 27 | 53 HA 110 DMH | 70 (56–82) | 94 (87–97) |
 < 24 | 62 (48–75) | 96 (91–99) | |||
 < 20 | 51 (37–65) | 100 (97–100) | |||
Zeugswetter et al. 2014 |  ≤ 22 | 38 HA 107 DMH | 92 | 91 | |
Adler et al. 2007 |  < 27 | 76 HA 200 HP | 89 (80–95) | 97 (93–99) | |
 < 24 | 79 (67–86) | 100 (97–100) | |||
Boretti et al. 2015 |  ≤ 24 | 23 HA 109 DMH | 56 (35–77) | 99 (93–100) | |
Reagan et al. 2020 | Machine algorithm |  | 133 HA + 908 DMH | 96.3 (81.7–99.8) | 97.2 (93.7–98.8) |
Wenger et al. 2010 | Right adrenal gland thickness |  < 3.05 mm | 22 HA, 14 H, 10 NAI | 82 | 90 |
Left adrenal gland thickness |  < 2.8 mm | 29 HA, 14 H, 10 NAI | 90 | 100 | |
Lennon et al. 2007 | Basal cortisol |  ≤ 55 nmol/L | 13 HA 110 NAI | 100 | 78.2 |
 ≤ 27.59 nmol/L | 100 | 98.2 | |||
Bovens et al. 2014 |  ≤ 55 nmol/L | 14HA 450 NAI | 100 | 63.3 | |
 ≤ 27.59 nmol/L | 85.7 | 91.8 | |||
Boretti et al. 2015 |  ≤ 55 nmol/L | 23 HA 109 DMH | 100 (85–100) | 20 (13–22) | |
Gold et al. 2016 |  ≤ 55 nmol/L | 163 HA 359 NAI | 99.4 | 67 | |
 < 22 nmol/L | 96.9 | 95.7 | |||
 ≤ 5.5 nmol/L | 81.6 | 99.1 | |||
Zeugswetter et al. 2014 | eACTH |  > 50 pmol/L | 38 HA 107 DMH | 96 | 100 |
Boretti et al. 2015 |  > 178 pg/mL | 23 HA 109 DMH | 91 (72–99) | 99 (93–100) | |
Boretti et al. 2015 | Cortisol to eACTH ratio |  ≤ 0.01 | 23 HA 109 DMH | 100 (85–100) | 99 (93–100) |