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Table 5 SNPs in different breeds that are not in Hardy-Weinberg Equilibrium (p < 0.05)

From: Non-synonymous genetic variation in exonic regions of canine Toll-like receptors

Breed

Canine gene

AA change

SNP

Genotypes a

p-value

SNP prediction b

Yorkshire

TLR10

T361M

C/T

1/1/9

0.0416978

Prob. damaging

Yorkshire

TLR10

M592V

A/G

1/1/9

0.0416978

Benign

French B.

TLR4

V82M

G/A

4/2/8

0.0099493

Pos. damaging

French B.

TLR4

H200Q

C/A

6/1/7

0.0013535

Pos. damaging*

French B.

TLR4

K230E

A/G

6/1/7

0.0013535

Benign

French B.

TLR5

S177N

G/A

0/11/3

0.0154748

Benign

  1. agenotypes, indicate genotype count for reference homozygotes, heterozygotes and alternative homozygotes. bSNP prediction, using Polyphen-2 classification. *possibly damaging when reference allele is tested as alternative in the SNP.
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Canine Medicine and Genetics

ISSN: 2662-9380