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  1. Inbreeding is a phenomenon that accumulates through the mating of relatives within closed populations, such as pedigree dog breeds, and results in reduced genetic variation within breeds, and may lead to poore...

    Authors: Mateja Janes, Thomas W. Lewis, Joanna J. Ilska and John A. Woolliams

    Citation: Canine Medicine and Genetics 2020 7:14

    Content type: Research

    Published on:

  2. The Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data fr...

    Authors: Camilla Pegram, Katie Wonham, Dave C. Brodbelt, David B. Church and Dan G. O’Neill

    Citation: Canine Medicine and Genetics 2020 7:13

    Content type: Research

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  3. Idiopathic epilepsy (IE) is a common neurological disorder in the domestic dog, and is defined as repeated seizure activity having no identifiable underlying cause. Some breeds, such as the Belgian shepherd do...

    Authors: J. M. Belanger, T. R. Famula, L. C. Gershony, M. K. Palij and A. M. Oberbauer

    Citation: Canine Medicine and Genetics 2020 7:12

    Content type: Research

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  4. The active metabolite of vitamin D, calcitriol, has been shown across many different species to augment innate immune responses and dampen aberrant proinflammatory cytokine production. Community acquired infec...

    Authors: Jared A. Jaffey, Mariah Bessette, Zenan Tao, Nancy Bradley-Siemens and Melissa Thompson

    Citation: Canine Medicine and Genetics 2020 7:11

    Content type: Research

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  5. Evidence for an autoimmune etiology in canine diabetes is inconsistent and could vary based on breed. Previous studies demonstrated that small percentages of diabetic dogs possess autoantibodies to antigens kn...

    Authors: Allison L. O’Kell, Clive H. Wasserfall, Paula S. Henthorn, Mark A. Atkinson and Rebecka S. Hess

    Citation: Canine Medicine and Genetics 2020 7:10

    Content type: Research

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  6. Although, in general, cancer is considered a multifactorial disease, clustering of particular cancers in pedigrees suggests a genetic predisposition and could explain why some dog breeds appear to have an incr...

    Authors: Anna L. W. Huskey, Katie Goebel, Carlos Lloveras-Fuentes, Isaac McNeely and Nancy D. Merner

    Citation: Canine Medicine and Genetics 2020 7:8

    Content type: Research

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  7. The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, r...

    Authors: Silvan R. Urfer, Matt Kaeberlein, Daniel E. L. Promislow and Kate E. Creevy

    Citation: Canine Medicine and Genetics 2020 7:7

    Content type: Research

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  8. Diabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives of this study were to estimate prevalence and incidence of DM in dogs, and to explore risk factors for DM and the survival of D...

    Authors: Angela M. Heeley, Dan G. O’Neill, Lucy J. Davison, David B. Church, Ellie K. Corless and Dave C. Brodbelt

    Citation: Canine Medicine and Genetics 2020 7:6

    Content type: Research

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  9. Discrete breed ideals are not restricted to delimiting dog breeds from another, but also are key drivers of subpopulation differentiation. As genetic differentiation due to population fragmentation results in ...

    Authors: Sara Lampi, Jonas Donner, Heidi Anderson and Jaakko Pohjoismäki

    Citation: Canine Medicine and Genetics 2020 7:5

    Content type: Research

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  10. Dogs are the most popular mammal kept as a companion animal globally. Positive human-dog relationships can benefit both the human owners as well as the dogs. However, popularity as a companion animal species d...

    Authors: Camilla L. Pegram, Brenda N. Bonnett, Helena Skarp, Gareth Arnott, Hannah James, Åke Hedhammar, Gregoire Leroy, Aimée Llewellyn-Zaidi, Ian J. Seath and Dan G. O’Neill

    Citation: Canine Medicine and Genetics 2020 7:4

    Content type: Meeting report

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  11. The calculation of demographic measures is a useful tool for evaluating the genomic architecture of dog breeds and enables ranking dog breeds in terms of genetic diversity. To achieve this for the German Dalma...

    Authors: Danae Vasiliadis, Julia Metzger and Ottmar Distl

    Citation: Canine Medicine and Genetics 2020 7:3

    Content type: Research

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  12. Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the dis...

    Authors: Alisdair M. Boag, Andrea Short, Lorna J. Kennedy, Hattie Syme, Peter A. Graham and Brian Catchpole

    Citation: Canine Medicine and Genetics 2020 7:2

    Content type: Research

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  13. Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, ...

    Authors: Dan G. O’Neill, Dave C. Brodbelt, Rebecca Hodge, David B. Church and Richard L. Meeson

    Citation: Canine Medicine and Genetics 2020 7:1

    Content type: Research

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  14. Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. T...

    Authors: Samantha L. Fousse, William D. Tyrrell, Mariellen E. Dentino, Frances L. Abrams, Steven L. Rosenthal and Joshua A. Stern

    Citation: Canine Genetics and Epidemiology 2019 6:11

    Content type: Research

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  15. N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene. Most...

    Authors: Yumiko Uno, Shota Kawakami, Kazuhiko Ochiai and Toshinori Omi

    Citation: Canine Genetics and Epidemiology 2019 6:9

    Content type: Research

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  16. In the original publication of this article [1], due to an error in a single count relating to the denominator used for this study, some of the derived values were wrong, so that abstract, plain English summar...

    Authors: Dan G. O’Neill, Zoie F. Ballantyne, Anke Hendricks, David B. Church, Dave C. Brodbelt and Camilla Pegram

    Citation: Canine Genetics and Epidemiology 2019 6:8

    Content type: Correction

    Published on:

    The original article was published in Canine Genetics and Epidemiology 2019 6:7

  17. The West Highland White Terrier (WHWT) is a relatively common breed in the UK, although Kennel Club registrations have declined in recent years. The VetCompass™ Programme collates de-identified clinical data f...

    Authors: Dan G. O’Neill, Zoie F. Ballantyne, Anke Hendricks, David B. Church, Dave C. Brodbelt and Camilla Pegram

    Citation: Canine Genetics and Epidemiology 2019 6:7

    Content type: Research

    Published on:

    The Correction to this article has been published in Canine Genetics and Epidemiology 2019 6:8

  18. The greyhound is a sighthound known for its speed and agility. Greyhounds were selectively bred as functional racing animals but increasingly are kept as pets in the UK, often after their racing careers are ov...

    Authors: Dan G. O’Neill, Nicola J. Rooney, Callum Brock, David B. Church, Dave C. Brodbelt and Camilla Pegram

    Citation: Canine Genetics and Epidemiology 2019 6:4

    Content type: Research

    Published on:

  19. In humans, ADAMTS17 mutations are known to cause Weill-Marchesani-like syndrome, which is characterised by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Breed-specific homozygous m...

    Authors: Emily C. Jeanes, James A. C. Oliver, Sally L. Ricketts, David J. Gould and Cathryn S. Mellersh

    Citation: Canine Genetics and Epidemiology 2019 6:5

    Content type: Research

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  20. Von Willebrand disorder type I (vWDI) is known as an inherited bleeding disorder in different dog breeds following an autosomal recessive inheritance. The Kromfohrländer is a rare dog breed with an increased i...

    Authors: Julia H. Segert, Jana-Marie Seidel, Walter J. Wurzer and Anja M. Geretschlaeger

    Citation: Canine Genetics and Epidemiology 2019 6:3

    Content type: Research

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  21. Primary hypoadrenocorticism (Addison’s disease, AD) and symmetrical lupoid onychodystrophy (SLO) are two clinical conditions with an autoimmune etiology that occur in multiple dog breeds. In man, autoimmunity ...

    Authors: Liza C. Gershony, Janelle M. Belanger, Andrea D. Short, Myly Le, Marjo K. Hytönen, Hannes Lohi, Thomas R. Famula, Lorna J. Kennedy and Anita M. Oberbauer

    Citation: Canine Genetics and Epidemiology 2019 6:2

    Content type: Research

    Published on:

  22. Individual dog breeds are often reported as predisposed to specific breed-related disorders but reliable epidemiological data on disease prevalence are sparse. The Miniature Schnauzer in the UK is a popular sm...

    Authors: Dan G. O’Neill, Charlotte Butcher, David B. Church, Dave C. Brodbelt and Alex G. Gough

    Citation: Canine Genetics and Epidemiology 2019 6:1

    Content type: Research

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  23. Selective breeding in populations with a limited effective population size may result in a loss of genetic diversity, which can cause an increased concentration of specific disease liability genes. The Dutch S...

    Authors: S. F. A. Keijser, H. Fieten, M. Vos-Loohuis, C. J. Piek, H. Anderson, J. Donner, I. Scholten, M. Nielen, J. W. Hesselink and F. G. van Steenbeek

    Citation: Canine Genetics and Epidemiology 2018 5:12

    Content type: Research

    Published on:

  24. Intervertebral disc herniation (IVDH) involves displacement of the intervertebral disc secondary to disc degeneration and is extremely common in dachshunds. Clinical signs include pain with or without paresis ...

    Authors: Marianne Dorn and Ian J. Seath

    Citation: Canine Genetics and Epidemiology 2018 5:11

    Content type: Research

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  25. Labrador retrievers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commo...

    Authors: Paul D. McGreevy, Bethany J. Wilson, Caroline S. Mansfield, Dave C. Brodbelt, David B. Church, Navneet Dhand, Ricardo J. Soares Magalhães and Dan G. O’Neill

    Citation: Canine Genetics and Epidemiology 2018 5:8

    Content type: Research

    Published on:

  26. The domestic dog is one of the most diverse mammalian species, exhibiting wide variations in morphology, behaviour and morbidity across breeds. Therefore, it is not unexpected that breeds should also exhibit v...

    Authors: T. W. Lewis, B. M. Wiles, A. M. Llewellyn-Zaidi, K. M. Evans and D. G. O’Neill

    Citation: Canine Genetics and Epidemiology 2018 5:10

    Content type: Research

    Published on:

  27. Lipomas are masses of mesenchymal origin, comprising of adipocytes, and are often clinically unremarkable but can be alarming to owners. Although lipomas are reportedly common in dogs, no studies have specific...

    Authors: Dan G. O’Neill, Caroline H. Corah, David B. Church, Dave C. Brodbelt and Lynda Rutherford

    Citation: Canine Genetics and Epidemiology 2018 5:9

    Content type: Research

    Published on:

  28. Working dog handlers and breeders have very different behavioural requirements in the animals that they employ for managing livestock. The Australian Working Kelpie breed may be used in several working context...

    Authors: Jonathan B. Early, Elizabeth A. Arnott, Lisa J. Mascord, Diane van Rooy, Paul D. McGreevy and Claire M. Wade

    Citation: Canine Genetics and Epidemiology 2018 5:5

    Content type: Research

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  29. Despite its Gallic name, the French Bulldog is a breed of both British and French origin that was first recognised by The Kennel Club in 1906. The French Bulldog has demonstrated recent rapid rises in Kennel C...

    Authors: Dan G. O’Neill, Lauren Baral, David B. Church, Dave C. Brodbelt and Rowena M. A. Packer

    Citation: Canine Genetics and Epidemiology 2018 5:3

    Content type: Research

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  30. Canine DNA-testing has become an important tool in purebred dog breeding and many breeders use genetic testing results when planning their breeding strategies. In addition, information obtained from testing of...

    Authors: Saija Ahonen, Ian Seath, Clare Rusbridge, Susan Holt, Gill Key, Travis Wang, Peixiang Wang and Berge A. Minassian

    Citation: Canine Genetics and Epidemiology 2018 5:2

    Content type: Research

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  31. The selection of a future breeding dog is a complicated task, in which disease characteristics and different traits have to be combined and weighed against one another. Truncation selection, that is the exclus...

    Authors: Katrien Wijnrocx, Liesbeth François, Peter Goos, Nadine Buys and Steven Janssens

    Citation: Canine Genetics and Epidemiology 2018 5:1

    Content type: Research

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  32. Breed-related health problems in dogs have received increased focus over the last decade. Responsibility for causing and/or solving these problems has been variously directed towards dog breeders and kennel cl...

    Authors: Dan G. O’Neill, Sylvia F. A. Keijser, Åke Hedhammar, Caroline Kisko, Gregoire Leroy, Aimée Llewellyn-Zaidi, Sofia Malm, Patricia N. Olson, Rowena M. A. Packer, Jean Francois Rousselot, Ian J. Seath, Jason W. Stull and Brenda N. Bonnett

    Citation: Canine Genetics and Epidemiology 2017 4:16

    Content type: Research

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  33. The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers rec...

    Authors: Dan G. O’Neill, Elisabeth C. Darwent, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2017 4:15

    Content type: Research

    Published on:

  34. Rottweilers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commonly reco...

    Authors: Dan G. O’Neill, Wee Yin Seah, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2017 4:13

    Content type: Research

    Published on:

  35. Pure breeding of dogs has led to over 700 heritable disorders, of which almost 300 are Mendelian in nature. Seventy percent of the characterized mutations have an autosomal recessive mode of inheritance, indic...

    Authors: Niels C. Pedersen, Bonnie Shope and Hongwei Liu

    Citation: Canine Genetics and Epidemiology 2017 4:11

    Content type: Research

    Published on:

    The Letter to the Editor to this article has been published in Canine Genetics and Epidemiology 2018 5:4

  36. Studying cancer and other diseases poses a problem due to their protracted and multifactorial nature. Prospective studies are useful to investigate chronic disease processes since collection of lifestyle infor...

    Authors: Melissa Simpson, Erin Searfoss, Sharon Albright, Diane E. Brown, Barbara Wolfe, Nancy K. Clark, Susan E. McCann, David Haworth, Mike Guy and Rod Page

    Citation: Canine Genetics and Epidemiology 2017 4:14

    Content type: Research

    Published on:

  37. Canine lumbosacral stenosis is defined as narrowing of the caudal lumbar and/or sacral vertebral canal. A risk factor for neurologic problems in many large sized breeds, lumbosacral stenosis can also cause ear...

    Authors: Meenakshi Mukherjee, Jeryl C. Jones and Jianbo Yao

    Citation: Canine Genetics and Epidemiology 2017 4:12

    Content type: Research

    Published on:

  38. Genetic polymorphisms within the glutathione S-transferase P1 (GSTP1) gene affect the elimination of toxic xenobiotics by the GSTP1 enzyme. In dogs, exposure to environmental chemicals that may be GSTP1 substrate...

    Authors: James Sacco, Sarah Mann and Keller Toral

    Citation: Canine Genetics and Epidemiology 2017 4:9

    Content type: Research

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  39. Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features. However, few studies empiric...

    Authors: B. M. Wiles, A. M. Llewellyn-Zaidi, K.M. Evans, D. G. O’Neill and T. W. Lewis

    Citation: Canine Genetics and Epidemiology 2017 4:8

    Content type: Research

    Published on:

  40. The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are no...

    Authors: Dan G. O’Neill, Noel R. Coulson, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2017 4:7

    Content type: Research

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  41. Corneal ulcerative disease (CUD) has the potential to adversely affect animal welfare by interfering with vision and causing pain. The study aimed to investigate for the first time the prevalence, breed-based ...

    Authors: Dan G. O’Neill, Monica M. Lee, Dave C. Brodbelt, David B. Church and Rick F. Sanchez

    Citation: Canine Genetics and Epidemiology 2017 4:5

    Content type: Research

    Published on:

  42. Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of...

    Authors: Janelle M. Belanger, Thomas P. Bellumori, Danika L. Bannasch, Thomas R. Famula and Anita M. Oberbauer

    Citation: Canine Genetics and Epidemiology 2017 4:6

    Content type: Research

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  43. Concentrated breeding effort to produce various body structures and behaviors of dogs to suit human demand has inadvertently produced unwanted traits and diseases that accompany the morphological and behaviora...

    Authors: Mark J. Fealey, Joy Li, Rebel J. E. Todhunter, Ursula Krotscheck, Kei Hayashi, Marina J. McConkey, Adam R. Boyko, Jessica J. Hayward and Rory J. Todhunter

    Citation: Canine Genetics and Epidemiology 2017 4:4

    Content type: Research

    Published on:

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