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29 days to first decision for reviewed manuscripts only
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Page 1 of 2
In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome. Affected patients typically respond to bile acid sequestrants, such as cholestyr...
Citation: Canine Medicine and Genetics 2021 8:1
Cases of foreleg deformities, characterized by varying degrees of shortened and bowed forelegs, have been reported in the Havanese breed. Because the health and welfare implications are severe in some of the a...
Citation: Canine Medicine and Genetics 2020 7:19
Approximately every fifth Dachshund is affected by disc herniation - a painful, hereditary condition which is typically preceded by disc calcification. Therefore, the selection of dogs suitable for breeding ca...
Citation: Canine Medicine and Genetics 2020 7:18
An autosomal recessive, rapidly progressive degenerative neuropathy known as infantile neuroaxonal dystrophy (NAD) was originally reported in Papillion puppies in 1995. In 2015, a causative missense variant in...
Citation: Canine Medicine and Genetics 2020 7:17
The Melanocortin 1 Receptor (MC1R) plays a central role in regulation of coat color determination in various species and is commonly referred to as the “E (extension) Locus”. Allelic variation of the MC1R gene is...
Citation: Canine Medicine and Genetics 2020 7:16
Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, ...
Citation: Canine Medicine and Genetics 2020 7:15
Inbreeding is a phenomenon that accumulates through the mating of relatives within closed populations, such as pedigree dog breeds, and results in reduced genetic variation within breeds, and may lead to poore...
Citation: Canine Medicine and Genetics 2020 7:14
The Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data fr...
Citation: Canine Medicine and Genetics 2020 7:13
Idiopathic epilepsy (IE) is a common neurological disorder in the domestic dog, and is defined as repeated seizure activity having no identifiable underlying cause. Some breeds, such as the Belgian shepherd do...
Citation: Canine Medicine and Genetics 2020 7:12
The active metabolite of vitamin D, calcitriol, has been shown across many different species to augment innate immune responses and dampen aberrant proinflammatory cytokine production. Community acquired infec...
Citation: Canine Medicine and Genetics 2020 7:11
Evidence for an autoimmune etiology in canine diabetes is inconsistent and could vary based on breed. Previous studies demonstrated that small percentages of diabetic dogs possess autoantibodies to antigens kn...
Citation: Canine Medicine and Genetics 2020 7:10
Citation: Canine Medicine and Genetics 2020 7:9
Although, in general, cancer is considered a multifactorial disease, clustering of particular cancers in pedigrees suggests a genetic predisposition and could explain why some dog breeds appear to have an incr...
Citation: Canine Medicine and Genetics 2020 7:8
The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, r...
Citation: Canine Medicine and Genetics 2020 7:7
Diabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives of this study were to estimate prevalence and incidence of DM in dogs, and to explore risk factors for DM and the survival of D...
Citation: Canine Medicine and Genetics 2020 7:6
Discrete breed ideals are not restricted to delimiting dog breeds from another, but also are key drivers of subpopulation differentiation. As genetic differentiation due to population fragmentation results in ...
Citation: Canine Medicine and Genetics 2020 7:5
Dogs are the most popular mammal kept as a companion animal globally. Positive human-dog relationships can benefit both the human owners as well as the dogs. However, popularity as a companion animal species d...
Citation: Canine Medicine and Genetics 2020 7:4
The calculation of demographic measures is a useful tool for evaluating the genomic architecture of dog breeds and enables ranking dog breeds in terms of genetic diversity. To achieve this for the German Dalma...
Citation: Canine Medicine and Genetics 2020 7:3
Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the dis...
Citation: Canine Medicine and Genetics 2020 7:2
Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, ...
Citation: Canine Medicine and Genetics 2020 7:1
Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. T...
Citation: Canine Genetics and Epidemiology 2019 6:11
Making assumptions regarding temperament and intelligence based on the physical appearance of dogs can be a conscious or unconscious human act. Labrador retrievers with chocolate-coloured coats are anecdotally...
Citation: Canine Genetics and Epidemiology 2019 6:10
N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene. Most...
Citation: Canine Genetics and Epidemiology 2019 6:9
In the original publication of this article [1], due to an error in a single count relating to the denominator used for this study, some of the derived values were wrong, so that abstract, plain English summar...
Citation: Canine Genetics and Epidemiology 2019 6:8
The West Highland White Terrier (WHWT) is a relatively common breed in the UK, although Kennel Club registrations have declined in recent years. The VetCompass™ Programme collates de-identified clinical data f...
Citation: Canine Genetics and Epidemiology 2019 6:7
The absence of selective pressure against recessive deleterious mutations in the heterozygous state means that virtually every individual will carry several such mutations which have arisen over time. The infl...
Citation: Canine Genetics and Epidemiology 2019 6:6
The greyhound is a sighthound known for its speed and agility. Greyhounds were selectively bred as functional racing animals but increasingly are kept as pets in the UK, often after their racing careers are ov...
Citation: Canine Genetics and Epidemiology 2019 6:4
In humans, ADAMTS17 mutations are known to cause Weill-Marchesani-like syndrome, which is characterised by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Breed-specific homozygous m...
Citation: Canine Genetics and Epidemiology 2019 6:5
Von Willebrand disorder type I (vWDI) is known as an inherited bleeding disorder in different dog breeds following an autosomal recessive inheritance. The Kromfohrländer is a rare dog breed with an increased i...
Citation: Canine Genetics and Epidemiology 2019 6:3
Primary hypoadrenocorticism (Addison’s disease, AD) and symmetrical lupoid onychodystrophy (SLO) are two clinical conditions with an autoimmune etiology that occur in multiple dog breeds. In man, autoimmunity ...
Citation: Canine Genetics and Epidemiology 2019 6:2
Individual dog breeds are often reported as predisposed to specific breed-related disorders but reliable epidemiological data on disease prevalence are sparse. The Miniature Schnauzer in the UK is a popular sm...
Citation: Canine Genetics and Epidemiology 2019 6:1
Selective breeding in populations with a limited effective population size may result in a loss of genetic diversity, which can cause an increased concentration of specific disease liability genes. The Dutch S...
Citation: Canine Genetics and Epidemiology 2018 5:12
Intervertebral disc herniation (IVDH) involves displacement of the intervertebral disc secondary to disc degeneration and is extremely common in dachshunds. Clinical signs include pain with or without paresis ...
Citation: Canine Genetics and Epidemiology 2018 5:11
Labrador retrievers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commo...
Citation: Canine Genetics and Epidemiology 2018 5:8
The domestic dog is one of the most diverse mammalian species, exhibiting wide variations in morphology, behaviour and morbidity across breeds. Therefore, it is not unexpected that breeds should also exhibit v...
Citation: Canine Genetics and Epidemiology 2018 5:10
Lipomas are masses of mesenchymal origin, comprising of adipocytes, and are often clinically unremarkable but can be alarming to owners. Although lipomas are reportedly common in dogs, no studies have specific...
Citation: Canine Genetics and Epidemiology 2018 5:9
Citation: Canine Genetics and Epidemiology 2018 5(Suppl 2):7
Citation: Canine Genetics and Epidemiology 2018 5(Suppl 1):6
Working dog handlers and breeders have very different behavioural requirements in the animals that they employ for managing livestock. The Australian Working Kelpie breed may be used in several working context...
Citation: Canine Genetics and Epidemiology 2018 5:5
Despite its Gallic name, the French Bulldog is a breed of both British and French origin that was first recognised by The Kennel Club in 1906. The French Bulldog has demonstrated recent rapid rises in Kennel C...
Citation: Canine Genetics and Epidemiology 2018 5:3
Citation: Canine Genetics and Epidemiology 2018 5:4
Canine DNA-testing has become an important tool in purebred dog breeding and many breeders use genetic testing results when planning their breeding strategies. In addition, information obtained from testing of...
Citation: Canine Genetics and Epidemiology 2018 5:2
The selection of a future breeding dog is a complicated task, in which disease characteristics and different traits have to be combined and weighed against one another. Truncation selection, that is the exclus...
Citation: Canine Genetics and Epidemiology 2018 5:1
Breed-related health problems in dogs have received increased focus over the last decade. Responsibility for causing and/or solving these problems has been variously directed towards dog breeders and kennel cl...
Citation: Canine Genetics and Epidemiology 2017 4:16
The Border Terrier is a working terrier type that is generally considered to be a relatively healthy and hardy breed. This study aimed to characterise the demography and common disorders of Border Terriers rec...
Citation: Canine Genetics and Epidemiology 2017 4:15
Rottweilers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commonly reco...
Citation: Canine Genetics and Epidemiology 2017 4:13
Pure breeding of dogs has led to over 700 heritable disorders, of which almost 300 are Mendelian in nature. Seventy percent of the characterized mutations have an autosomal recessive mode of inheritance, indic...
Citation: Canine Genetics and Epidemiology 2017 4:11
Studying cancer and other diseases poses a problem due to their protracted and multifactorial nature. Prospective studies are useful to investigate chronic disease processes since collection of lifestyle infor...
Citation: Canine Genetics and Epidemiology 2017 4:14
Canine lumbosacral stenosis is defined as narrowing of the caudal lumbar and/or sacral vertebral canal. A risk factor for neurologic problems in many large sized breeds, lumbosacral stenosis can also cause ear...
Citation: Canine Genetics and Epidemiology 2017 4:12
Genetic polymorphisms within the glutathione S-transferase P1 (GSTP1) gene affect the elimination of toxic xenobiotics by the GSTP1 enzyme. In dogs, exposure to environmental chemicals that may be GSTP1 substrate...
Citation: Canine Genetics and Epidemiology 2017 4:9
Speed
29 days to first decision for reviewed manuscripts only
29 days to first decision for all manuscripts
67 days from submission to acceptance
23 days from acceptance to publication
Usage
115,793 downloads
84 Altmetric mentions
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