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  1. Shih Tzus are a popular dog breed in the UK although there is relatively little reported information on their health. This study aimed to characterise the demography, common disorders and mortality of Shih Tzu...

    Authors: Fiona Dale, Dave C. Brodbelt, Gabriella West, David B. Church, Yan Hui Lee and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2024 11:2
  2. The English Cocker Spaniel (ECS) is one of the most popular dog breeds in the UK but information on disorder predisposition and protection is limited. Using anonymised veterinary clinical data from the VetComp...

    Authors: Karolina S. Engdahl, Dave C. Brodbelt, Carla Cameron, David B. Church and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2024 11:1
  3. The Shar Pei is a common dog breed with a distinctive appearance caused by hyaluronosis that has been linked with several health conditions. Anonymised primary-care veterinary clinical records were explored to...

    Authors: Dan G. O’Neill, Karolina S. Engdahl, Alice Leach, Rowena M. A. Packer, David B. Church and Dave C. Brodbelt
    Citation: Canine Medicine and Genetics 2023 10:11
  4. Cortical folding is related to the functional organization of the brain. The TMF-1 regulated protein (TRNP1) regulates the expansion and folding of the mammalian cerebral cortex, a process that may have been a...

    Authors: James C. Sacco, Emma Starr, Alyssa Weaver, Rachel Dietz and Muhammad A. Spocter
    Citation: Canine Medicine and Genetics 2023 10:10
  5. Distichiasis is a condition characterized by aberrant hairs along the eyelid margins. The symptoms are usually mild but can lead to ulcerations and lesions of the cornea in severe cases. It is the most frequen...

    Authors: Dina Jørgensen, Ernst-Otto Ropstad, Theodorus Meuwissen and Frode Lingaas
    Citation: Canine Medicine and Genetics 2023 10:9
  6. Osteosarcoma is a malignant bone neoplasia that has high welfare consequences for affected dogs. Awareness of breed and canine conformational risk factors for osteosarcoma can assist with earlier diagnosis and...

    Authors: Dan G. O’Neill, Grace L. Edmunds, Jade Urquhart-Gilmore, David B. Church, Lynda Rutherford, Matthew J. Smalley and Dave C. Brodbelt
    Citation: Canine Medicine and Genetics 2023 10:8
  7. Publicly available phenotype data and genotyping array data from two citizen science projects: “Doberman Health Surveys” and “The Doberman Diversity Project” were analyzed to explore relative homozygosity, div...

    Authors: Claire M. Wade, Robin Nuttall and Sophie Liu
    Citation: Canine Medicine and Genetics 2023 10:7
  8. The Boxer is a popular dog breed with a distinctive appearance. However, the breed has been linked with several health conditions, some of which have been associated with its moderately brachycephalic conforma...

    Authors: Dan G. O’Neill, Alison M. Skipper, Kate Barrett, David B. Church, Rowena M. A. Packer and Dave C. Brodbelt
    Citation: Canine Medicine and Genetics 2023 10:6
  9. The English Cocker Spaniel (ECS) is a common family dog in the UK. This study aimed to describe demography, morbidity, and mortality in ECS under primary veterinary care in the UK during 2016 using data from t...

    Authors: Karolina S. Engdahl, Dave C. Brodbelt, Carla Cameron, David B. Church, Åke Hedhammar and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2023 10:4
  10. Fear of firework noises and other loud, sudden noises (noise reactivity) is a significant problem for many dogs and may have a negative effect on both welfare and, in severe cases, the life expectancy of dogs....

    Authors: Karin Westereng Handegård, Linn Mari Storengen, Dina Joergensen and Frode Lingaas
    Citation: Canine Medicine and Genetics 2023 10:2
  11. Natural and anthropogenic disasters can have long-lasting impacts on the genetics and structure of impacted populations. The 1986 Chernobyl Nuclear Power Plant disaster led to extensive contamination of the lo...

    Authors: Megan N. Dillon, Rachael Thomas, Timothy A. Mousseau, Jennifer A. Betz, Norman J. Kleiman, Martha O. Burford Reiskind and Matthew Breen
    Citation: Canine Medicine and Genetics 2023 10:1
  12. Hypothyroidism is a commonly diagnosed endocrinopathy in dogs. This study aimed to investigate the frequency and risk factors for diagnosis of hypothyroidism in UK primary-care practice. Dogs diagnosed with hy...

    Authors: Dan G. O’Neill, Janine Su Pheng Khoo, Dave C. Brodbelt, David B. Church, Camilla Pegram and Rebecca F. Geddes
    Citation: Canine Medicine and Genetics 2022 9:11
  13. Lymphoma is the second most common cancer affecting Golden Retrievers and is hypothesized to arise through a complex interaction of genetic and environmental factors. The aim of this nested case–control study ...

    Authors: Kristofer R. Luethcke, Lauren A. Trepanier, Ashleigh N. Tindle and Julia D. Labadie
    Citation: Canine Medicine and Genetics 2022 9:10
  14. The English Bulldog has risen sharply in popularity over the past decade but its distinctive and extreme conformation is linked to several serious health conditions. Using multivariable analysis of anonymised ...

    Authors: Dan G. O’Neill, Alison Skipper, Rowena M. A. Packer, Caitriona Lacey, Dave C. Brodbelt, David B. Church and Camilla Pegram
    Citation: Canine Medicine and Genetics 2022 9:5
  15. Demand for intentional crosses of purebred dog breeds, often labelled ‘designer crossbreeds’ (e.g., Labrador Retriever X Poodle, the ‘Labradoodle’), has recently increased in the UK. This study aimed to explor...

    Authors: E. Burnett, C. L. Brand, D. G. O’Neill, C. L. Pegram, Z. Belshaw, K. B. Stevens and R. M. A. Packer
    Citation: Canine Medicine and Genetics 2022 9:8
  16. Dogs have an exquisite sense of olfaction. In many instances this ability has been utilized by humans for a wide range of important situations including detecting explosives and illegal drugs. It is accepted t...

    Authors: Naoual Azzouzi, Anne-Sophie Guillory, Gilles Chaudieu and Francis Galibert
    Citation: Canine Medicine and Genetics 2022 9:7
  17. Pugs are a brachycephalic dog breed that has become phenomenally popular over recent decades. However, there is growing concern about serious health and welfare issues in the breed. To augment the evidence-bas...

    Authors: Dan G. O’Neill, Jaya Sahota, Dave C. Brodbelt, David B. Church, Rowena M.A. Packer and Camilla Pegram
    Citation: Canine Medicine and Genetics 2022 9:4
  18. Hypoadrenocorticism is characterized by a reduction in mineralocorticoid and/or glucocorticoid production by the adrenal glands. Several subtypes have been described with different clinical and clinicopatholog...

    Authors: Pedro J. Guzmán Ramos, Michael Bennaim, Robert E. Shiel and Carmel T. Mooney
    Citation: Canine Medicine and Genetics 2022 9:6
  19. Cutaneous neoplastic diseases are the most and second-most frequently reported tumors in male and female dogs, respectively. The aims of this study were to report the occurrence of canine cutaneous tumors in a...

    Authors: Ana Luísa Martins, Ana Canadas-Sousa, João R. Mesquita, Patrícia Dias-Pereira, Irina Amorim and Fátima Gärtner
    Citation: Canine Medicine and Genetics 2022 9:2
  20. The year 2021 marked the centenary of the isolation of a therapeutic form of insulin and its successful use in dogs. This was a landmark moment that subsequently and rapidly led to the commercial manufacture o...

    Authors: Robert E. Shiel and Carmel T. Mooney
    Citation: Canine Medicine and Genetics 2022 9:1

    The Correction to this article has been published in Canine Medicine and Genetics 2022 9:3

  21. The French Bulldog is a highly popular dog breed but is linked with many serious health issues. A holistic view of breed health in French Bulldogs would assist efforts to appreciate the overall health strength...

    Authors: Dan G. O’Neill, Rowena M.A. Packer, Peter Francis, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Medicine and Genetics 2021 8:13
  22. Dog breeds are known for their distinctive body shape, size, coat color, head type and behaviors, features that are relatively similar across members of a breed. Unfortunately, dog breeds are also characterize...

    Authors: Danika Bannasch, Thomas Famula, Jonas Donner, Heidi Anderson, Leena Honkanen, Kevin Batcher, Noa Safra, Sara Thomasy and Robert Rebhun
    Citation: Canine Medicine and Genetics 2021 8:12
  23. Distichiasis is a presumed inherited eyelid disease, characterized by misplaced eyelashes. The effect on eye health and animal welfare varies between individuals; most mild cases show no clinical signs, but so...

    Authors: Kim K. L. Bellamy, Frode Lingaas and Per Madsen
    Citation: Canine Medicine and Genetics 2021 8:11
  24. A 2019 ACVIM consensus statement on diagnostics for immune-mediated hemolytic anemia (IMHA) in dogs made testing recommendations. As data on the performance of immunohematological tests was lacking, we underto...

    Authors: Nadine Idalan, Johanna O. Zeitz, Corinna N. Weber, Elisabeth Müller and Urs Giger
    Citation: Canine Medicine and Genetics 2021 8:10
  25. Osteosarcoma (OSA) is a devastating disease that is common in the Irish Wolfhound breed. The aim of this study was to use a pedigree-based approach to determine the heritability of OSA in the Irish Wolfhound u...

    Authors: Mehdi Momen, Nyah L. Kohler, Emily E. Binversie, Mariellen Dentino and Susannah J. Sample
    Citation: Canine Medicine and Genetics 2021 8:9
  26. Otitis externa is a commonly diagnosed disorder in dogs and can carry a high welfare impact on affected animals. This study aimed to report the prevalence and explore the role of breed and aural conformation a...

    Authors: Dan G. O’Neill, Andrea V. Volk, Teresa Soares, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Medicine and Genetics 2021 8:7
  27. Genetic heterogeneity of the canine angiotensin converting enzyme (ACE) gene is functionally important because the degree of aldosterone breakthrough with ACE-inhibitor therapy is greater in variant positive d...

    Authors: D. B. Adin, C. E. Atkins, S. G. Friedenberg, J. A. Stern and K. M. Meurs
    Citation: Canine Medicine and Genetics 2021 8:6
  28. Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload ...

    Authors: Eric S. Ontiveros and Joshua A. Stern
    Citation: Canine Medicine and Genetics 2021 8:4
  29. Canine idiopathic epilepsy (IE) is the most common chronic neurological brain disease in dogs, yet it can only be diagnosed by exclusion of all other potential causes. In people, epilepsy has been associated w...

    Authors: Fraje Watson, A. Augusto Coppi, Holger A. Volk, Rowena M. A. Packer, Anna Tauro and Clare Rusbridge
    Citation: Canine Medicine and Genetics 2021 8:3
  30. Osteosarcoma is an aggressive and painful bone neoplasm in dogs. Previous studies have reported epidemiological associations suggesting that large body mass, long bone length and the genetics of certain breeds...

    Authors: Grace L. Edmunds, Matthew J. Smalley, Sam Beck, Rachel J. Errington, Sara Gould, Helen Winter, Dave C. Brodbelt and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2021 8:2
  31. In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome. Affected patients typically respond to bile acid sequestrants, such as cholestyr...

    Authors: L. Toresson, J. M. Steiner and J. S. Suchodolski
    Citation: Canine Medicine and Genetics 2021 8:1

    The Correction to this article has been published in Canine Medicine and Genetics 2021 8:5

  32. Approximately every fifth Dachshund is affected by disc herniation - a painful, hereditary condition which is typically preceded by disc calcification. Therefore, the selection of dogs suitable for breeding ca...

    Authors: Camilla Sichlau Bruun, Charlotte Bruun, Tine Marx, Helle Friis Proschowsky and Merete Fredholm
    Citation: Canine Medicine and Genetics 2020 7:18
  33. The Melanocortin 1 Receptor (MC1R) plays a central role in regulation of coat color determination in various species and is commonly referred to as the “E (extension) Locus”. Allelic variation of the MC1R gene is...

    Authors: Heidi Anderson, Leena Honkanen, Päivi Ruotanen, Julia Mathlin and Jonas Donner
    Citation: Canine Medicine and Genetics 2020 7:16
  34. Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, ...

    Authors: A. L. Denyer, J. P. Massey, L. J. Davison, W. E. R. Ollier, B. Catchpole and L. J. Kennedy
    Citation: Canine Medicine and Genetics 2020 7:15
  35. Inbreeding is a phenomenon that accumulates through the mating of relatives within closed populations, such as pedigree dog breeds, and results in reduced genetic variation within breeds, and may lead to poore...

    Authors: Mateja Janes, Thomas W. Lewis, Joanna J. Ilska and John A. Woolliams
    Citation: Canine Medicine and Genetics 2020 7:14
  36. The Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data fr...

    Authors: Camilla Pegram, Katie Wonham, Dave C. Brodbelt, David B. Church and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2020 7:13
  37. Idiopathic epilepsy (IE) is a common neurological disorder in the domestic dog, and is defined as repeated seizure activity having no identifiable underlying cause. Some breeds, such as the Belgian shepherd do...

    Authors: J. M. Belanger, T. R. Famula, L. C. Gershony, M. K. Palij and A. M. Oberbauer
    Citation: Canine Medicine and Genetics 2020 7:12
  38. The active metabolite of vitamin D, calcitriol, has been shown across many different species to augment innate immune responses and dampen aberrant proinflammatory cytokine production. Community acquired infec...

    Authors: Jared A. Jaffey, Mariah Bessette, Zenan Tao, Nancy Bradley-Siemens and Melissa Thompson
    Citation: Canine Medicine and Genetics 2020 7:11
  39. Evidence for an autoimmune etiology in canine diabetes is inconsistent and could vary based on breed. Previous studies demonstrated that small percentages of diabetic dogs possess autoantibodies to antigens kn...

    Authors: Allison L. O’Kell, Clive H. Wasserfall, Paula S. Henthorn, Mark A. Atkinson and Rebecka S. Hess
    Citation: Canine Medicine and Genetics 2020 7:10
  40. Although, in general, cancer is considered a multifactorial disease, clustering of particular cancers in pedigrees suggests a genetic predisposition and could explain why some dog breeds appear to have an incr...

    Authors: Anna L. W. Huskey, Katie Goebel, Carlos Lloveras-Fuentes, Isaac McNeely and Nancy D. Merner
    Citation: Canine Medicine and Genetics 2020 7:8

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