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  1. Lymphoma is the second most common cancer affecting Golden Retrievers and is hypothesized to arise through a complex interaction of genetic and environmental factors. The aim of this nested case–control study ...

    Authors: Kristofer R. Luethcke, Lauren A. Trepanier, Ashleigh N. Tindle and Julia D. Labadie
    Citation: Canine Medicine and Genetics 2022 9:10
    Content type: Short report Published on:

  2. The English Bulldog has risen sharply in popularity over the past decade but its distinctive and extreme conformation is linked to several serious health conditions. Using multivariable analysis of anonymised ...

    Authors: Dan G. O’Neill, Alison Skipper, Rowena M. A. Packer, Caitriona Lacey, Dave C. Brodbelt, David B. Church and Camilla Pegram
    Citation: Canine Medicine and Genetics 2022 9:5
    Content type: Research Published on:

  4. Demand for intentional crosses of purebred dog breeds, often labelled ‘designer crossbreeds’ (e.g., Labrador Retriever X Poodle, the ‘Labradoodle’), has recently increased in the UK. This study aimed to explor...

    Authors: E. Burnett, C. L. Brand, D. G. O’Neill, C. L. Pegram, Z. Belshaw, K. B. Stevens and R. M. A. Packer
    Citation: Canine Medicine and Genetics 2022 9:8
    Content type: Research Published on:

  5. Dogs have an exquisite sense of olfaction. In many instances this ability has been utilized by humans for a wide range of important situations including detecting explosives and illegal drugs. It is accepted t...

    Authors: Naoual Azzouzi, Anne-Sophie Guillory, Gilles Chaudieu and Francis Galibert
    Citation: Canine Medicine and Genetics 2022 9:7
    Content type: Research Published on:

  6. Pugs are a brachycephalic dog breed that has become phenomenally popular over recent decades. However, there is growing concern about serious health and welfare issues in the breed. To augment the evidence-bas...

    Authors: Dan G. O’Neill, Jaya Sahota, Dave C. Brodbelt, David B. Church, Rowena M.A. Packer and Camilla Pegram
    Citation: Canine Medicine and Genetics 2022 9:4
    Content type: Research Published on:

  7. Hypoadrenocorticism is characterized by a reduction in mineralocorticoid and/or glucocorticoid production by the adrenal glands. Several subtypes have been described with different clinical and clinicopatholog...

    Authors: Pedro J. Guzmán Ramos, Michael Bennaim, Robert E. Shiel and Carmel T. Mooney
    Citation: Canine Medicine and Genetics 2022 9:6
    Content type: Review Published on:

  9. Cutaneous neoplastic diseases are the most and second-most frequently reported tumors in male and female dogs, respectively. The aims of this study were to report the occurrence of canine cutaneous tumors in a...

    Authors: Ana Luísa Martins, Ana Canadas-Sousa, João R. Mesquita, Patrícia Dias-Pereira, Irina Amorim and Fátima Gärtner
    Citation: Canine Medicine and Genetics 2022 9:2
    Content type: Research Published on:

  10. The year 2021 marked the centenary of the isolation of a therapeutic form of insulin and its successful use in dogs. This was a landmark moment that subsequently and rapidly led to the commercial manufacture o...

    Authors: Robert E. Shiel and Carmel T. Mooney
    Citation: Canine Medicine and Genetics 2022 9:1
    Content type: Review Published on:

    The Correction to this article has been published in Canine Medicine and Genetics 2022 9:3

  12. The French Bulldog is a highly popular dog breed but is linked with many serious health issues. A holistic view of breed health in French Bulldogs would assist efforts to appreciate the overall health strength...

    Authors: Dan G. O’Neill, Rowena M.A. Packer, Peter Francis, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Medicine and Genetics 2021 8:13
    Content type: Research Published on:

  13. Dog breeds are known for their distinctive body shape, size, coat color, head type and behaviors, features that are relatively similar across members of a breed. Unfortunately, dog breeds are also characterize...

    Authors: Danika Bannasch, Thomas Famula, Jonas Donner, Heidi Anderson, Leena Honkanen, Kevin Batcher, Noa Safra, Sara Thomasy and Robert Rebhun
    Citation: Canine Medicine and Genetics 2021 8:12
    Content type: Research Published on:

  14. Distichiasis is a presumed inherited eyelid disease, characterized by misplaced eyelashes. The effect on eye health and animal welfare varies between individuals; most mild cases show no clinical signs, but so...

    Authors: Kim K. L. Bellamy, Frode Lingaas and Per Madsen
    Citation: Canine Medicine and Genetics 2021 8:11
    Content type: Research Published on:

  15. A 2019 ACVIM consensus statement on diagnostics for immune-mediated hemolytic anemia (IMHA) in dogs made testing recommendations. As data on the performance of immunohematological tests was lacking, we underto...

    Authors: Nadine Idalan, Johanna O. Zeitz, Corinna N. Weber, Elisabeth Müller and Urs Giger
    Citation: Canine Medicine and Genetics 2021 8:10
    Content type: Research Published on:

  16. Osteosarcoma (OSA) is a devastating disease that is common in the Irish Wolfhound breed. The aim of this study was to use a pedigree-based approach to determine the heritability of OSA in the Irish Wolfhound u...

    Authors: Mehdi Momen, Nyah L. Kohler, Emily E. Binversie, Mariellen Dentino and Susannah J. Sample
    Citation: Canine Medicine and Genetics 2021 8:9
    Content type: Research Published on:

  18. Otitis externa is a commonly diagnosed disorder in dogs and can carry a high welfare impact on affected animals. This study aimed to report the prevalence and explore the role of breed and aural conformation a...

    Authors: Dan G. O’Neill, Andrea V. Volk, Teresa Soares, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Medicine and Genetics 2021 8:7
    Content type: Research Published on:

  19. Genetic heterogeneity of the canine angiotensin converting enzyme (ACE) gene is functionally important because the degree of aldosterone breakthrough with ACE-inhibitor therapy is greater in variant positive d...

    Authors: D. B. Adin, C. E. Atkins, S. G. Friedenberg, J. A. Stern and K. M. Meurs
    Citation: Canine Medicine and Genetics 2021 8:6
    Content type: Research Published on:

  21. Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload ...

    Authors: Eric S. Ontiveros and Joshua A. Stern
    Citation: Canine Medicine and Genetics 2021 8:4
    Content type: Review Published on:

  22. Canine idiopathic epilepsy (IE) is the most common chronic neurological brain disease in dogs, yet it can only be diagnosed by exclusion of all other potential causes. In people, epilepsy has been associated w...

    Authors: Fraje Watson, A. Augusto Coppi, Holger A. Volk, Rowena M. A. Packer, Anna Tauro and Clare Rusbridge
    Citation: Canine Medicine and Genetics 2021 8:3
    Content type: Research Published on:

  23. Osteosarcoma is an aggressive and painful bone neoplasm in dogs. Previous studies have reported epidemiological associations suggesting that large body mass, long bone length and the genetics of certain breeds...

    Authors: Grace L. Edmunds, Matthew J. Smalley, Sam Beck, Rachel J. Errington, Sara Gould, Helen Winter, Dave C. Brodbelt and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2021 8:2
    Content type: Research Published on:

  24. In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome. Affected patients typically respond to bile acid sequestrants, such as cholestyr...

    Authors: L. Toresson, J. M. Steiner and J. S. Suchodolski
    Citation: Canine Medicine and Genetics 2021 8:1
    Content type: Case Report Published on:

    The Correction to this article has been published in Canine Medicine and Genetics 2021 8:5

  26. Approximately every fifth Dachshund is affected by disc herniation - a painful, hereditary condition which is typically preceded by disc calcification. Therefore, the selection of dogs suitable for breeding ca...

    Authors: Camilla Sichlau Bruun, Charlotte Bruun, Tine Marx, Helle Friis Proschowsky and Merete Fredholm
    Citation: Canine Medicine and Genetics 2020 7:18
    Content type: Research Published on:

  28. The Melanocortin 1 Receptor (MC1R) plays a central role in regulation of coat color determination in various species and is commonly referred to as the “E (extension) Locus”. Allelic variation of the MC1R gene is...

    Authors: Heidi Anderson, Leena Honkanen, Päivi Ruotanen, Julia Mathlin and Jonas Donner
    Citation: Canine Medicine and Genetics 2020 7:16
    Content type: Research Published on:

  29. Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, ...

    Authors: A. L. Denyer, J. P. Massey, L. J. Davison, W. E. R. Ollier, B. Catchpole and L. J. Kennedy
    Citation: Canine Medicine and Genetics 2020 7:15
    Content type: Research Published on:

  30. Inbreeding is a phenomenon that accumulates through the mating of relatives within closed populations, such as pedigree dog breeds, and results in reduced genetic variation within breeds, and may lead to poore...

    Authors: Mateja Janes, Thomas W. Lewis, Joanna J. Ilska and John A. Woolliams
    Citation: Canine Medicine and Genetics 2020 7:14
    Content type: Research Published on:

  31. The Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data fr...

    Authors: Camilla Pegram, Katie Wonham, Dave C. Brodbelt, David B. Church and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2020 7:13
    Content type: Research Published on:

  32. Idiopathic epilepsy (IE) is a common neurological disorder in the domestic dog, and is defined as repeated seizure activity having no identifiable underlying cause. Some breeds, such as the Belgian shepherd do...

    Authors: J. M. Belanger, T. R. Famula, L. C. Gershony, M. K. Palij and A. M. Oberbauer
    Citation: Canine Medicine and Genetics 2020 7:12
    Content type: Research Published on:

  33. The active metabolite of vitamin D, calcitriol, has been shown across many different species to augment innate immune responses and dampen aberrant proinflammatory cytokine production. Community acquired infec...

    Authors: Jared A. Jaffey, Mariah Bessette, Zenan Tao, Nancy Bradley-Siemens and Melissa Thompson
    Citation: Canine Medicine and Genetics 2020 7:11
    Content type: Research Published on:

  34. Evidence for an autoimmune etiology in canine diabetes is inconsistent and could vary based on breed. Previous studies demonstrated that small percentages of diabetic dogs possess autoantibodies to antigens kn...

    Authors: Allison L. O’Kell, Clive H. Wasserfall, Paula S. Henthorn, Mark A. Atkinson and Rebecka S. Hess
    Citation: Canine Medicine and Genetics 2020 7:10
    Content type: Research Published on:

  36. Although, in general, cancer is considered a multifactorial disease, clustering of particular cancers in pedigrees suggests a genetic predisposition and could explain why some dog breeds appear to have an incr...

    Authors: Anna L. W. Huskey, Katie Goebel, Carlos Lloveras-Fuentes, Isaac McNeely and Nancy D. Merner
    Citation: Canine Medicine and Genetics 2020 7:8
    Content type: Research Published on:

  37. The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, r...

    Authors: Silvan R. Urfer, Matt Kaeberlein, Daniel E. L. Promislow and Kate E. Creevy
    Citation: Canine Medicine and Genetics 2020 7:7
    Content type: Research Published on:

  38. Diabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives of this study were to estimate prevalence and incidence of DM in dogs, and to explore risk factors for DM and the survival of D...

    Authors: Angela M. Heeley, Dan G. O’Neill, Lucy J. Davison, David B. Church, Ellie K. Corless and Dave C. Brodbelt
    Citation: Canine Medicine and Genetics 2020 7:6
    Content type: Research Published on:

  39. Discrete breed ideals are not restricted to delimiting dog breeds from another, but also are key drivers of subpopulation differentiation. As genetic differentiation due to population fragmentation results in ...

    Authors: Sara Lampi, Jonas Donner, Heidi Anderson and Jaakko Pohjoismäki
    Citation: Canine Medicine and Genetics 2020 7:5
    Content type: Research Published on:

  40. Dogs are the most popular mammal kept as a companion animal globally. Positive human-dog relationships can benefit both the human owners as well as the dogs. However, popularity as a companion animal species d...

    Authors: Camilla L. Pegram, Brenda N. Bonnett, Helena Skarp, Gareth Arnott, Hannah James, Åke Hedhammar, Gregoire Leroy, Aimée Llewellyn-Zaidi, Ian J. Seath and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2020 7:4
    Content type: Meeting report Published on:

  41. The calculation of demographic measures is a useful tool for evaluating the genomic architecture of dog breeds and enables ranking dog breeds in terms of genetic diversity. To achieve this for the German Dalma...

    Authors: Danae Vasiliadis, Julia Metzger and Ottmar Distl
    Citation: Canine Medicine and Genetics 2020 7:3
    Content type: Research Published on:

  42. Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the dis...

    Authors: Alisdair M. Boag, Andrea Short, Lorna J. Kennedy, Hattie Syme, Peter A. Graham and Brian Catchpole
    Citation: Canine Medicine and Genetics 2020 7:2
    Content type: Research Published on:

  43. Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, ...

    Authors: Dan G. O’Neill, Dave C. Brodbelt, Rebecca Hodge, David B. Church and Richard L. Meeson
    Citation: Canine Medicine and Genetics 2020 7:1
    Content type: Research Published on:

  44. Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. T...

    Authors: Samantha L. Fousse, William D. Tyrrell, Mariellen E. Dentino, Frances L. Abrams, Steven L. Rosenthal and Joshua A. Stern
    Citation: Canine Genetics and Epidemiology 2019 6:11
    Content type: Research Published on:

  46. N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene. Most...

    Authors: Yumiko Uno, Shota Kawakami, Kazuhiko Ochiai and Toshinori Omi
    Citation: Canine Genetics and Epidemiology 2019 6:9
    Content type: Research Published on:

  47. In the original publication of this article [1], due to an error in a single count relating to the denominator used for this study, some of the derived values were wrong, so that abstract, plain English summar...

    Authors: Dan G. O’Neill, Zoie F. Ballantyne, Anke Hendricks, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Genetics and Epidemiology 2019 6:8
    Content type: Correction Published on:

    The original article was published in Canine Genetics and Epidemiology 2019 6:7

  48. The West Highland White Terrier (WHWT) is a relatively common breed in the UK, although Kennel Club registrations have declined in recent years. The VetCompass™ Programme collates de-identified clinical data f...

    Authors: Dan G. O’Neill, Zoie F. Ballantyne, Anke Hendricks, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Genetics and Epidemiology 2019 6:7
    Content type: Research Published on:

    The Correction to this article has been published in Canine Genetics and Epidemiology 2019 6:8

  50. The greyhound is a sighthound known for its speed and agility. Greyhounds were selectively bred as functional racing animals but increasingly are kept as pets in the UK, often after their racing careers are ov...

    Authors: Dan G. O’Neill, Nicola J. Rooney, Callum Brock, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Genetics and Epidemiology 2019 6:4
    Content type: Research Published on:
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Canine Medicine and Genetics

ISSN: 2662-9380