Research
Genetic polymorphisms within the glutathione S-transferase P1 (GSTP1) gene affect the elimination of toxic xenobiotics by the GSTP1 enzyme. In dogs, exposure to environmental chemicals that may be GSTP1 substrate...
Canine Genetics and Epidemiology 2017 4:9
Published on: 11 October 2017
Letter to the Editor
Canine Genetics and Epidemiology 2017 4:10
Published on: 26 September 2017
Research
Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features. However, few studies empiric...
Canine Genetics and Epidemiology 2017 4:8
Published on: 19 September 2017
Research
The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are no...
Canine Genetics and Epidemiology 2017 4:7
Published on: 28 July 2017
Research
Corneal ulcerative disease (CUD) has the potential to adversely affect animal welfare by interfering with vision and causing pain. The study aimed to investigate for the first time the prevalence, breed-based ...
Canine Genetics and Epidemiology 2017 4:5
Published on: 15 June 2017
Research
Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of...
Canine Genetics and Epidemiology 2017 4:6
Published on: 26 May 2017
Research
Concentrated breeding effort to produce various body structures and behaviors of dogs to suit human demand has inadvertently produced unwanted traits and diseases that accompany the morphological and behaviora...
Canine Genetics and Epidemiology 2017 4:4
Published on: 24 March 2017
Research
Osteosarcoma is the most common neoplastic disease in Scottish Deerhounds. For Deerhounds, a 2007 population-based study concluded that a single dominant genetic factor largely governed disease risk. For Greyh...
Canine Genetics and Epidemiology 2017 4:3
Published on: 17 March 2017
Research
Exercise-induced collapse (EIC) due to DNM1 mutation and rupture of the cranial cruciate ligament are both common syndromes in the Labrador retriever breed. A cohort of 313 Labradors was recruited based on their ...
Canine Genetics and Epidemiology 2017 4:2
Published on: 2 February 2017
Research
In humans, reduced activity of the enzyme monoamine oxidase type A (MAOA) due to genetic polymorphisms within the MAOA gene leads to increased brain neurotransmitter levels associated with aggression. In order to...
Canine Genetics and Epidemiology 2017 4:1
Published on: 13 January 2017
Research
Despite decades of studying, the mechanisms maintaining high diversity in the genes of the Major Histocompatibility Complex (MHC) are still puzzling scientists. In addition to pathogen recognition and other fu...
Canine Genetics and Epidemiology 2016 3:9
Published on: 18 November 2016
Research
Intervertebral disc disease (IVDD) represents a major problem in the Dachshund, with at a relative risk of IVDD 10–12 times higher than other breeds, and an estimated 19–24 % of Dachshunds showing clinical sig...
Canine Genetics and Epidemiology 2016 3:8
Published on: 5 November 2016
Research
This study examines genetic diversity among 102 registered English Bulldogs used for breeding based on maternal and paternal haplotypes, allele frequencies in 33 highly polymorphic short tandem repeat (STR) lo...
Canine Genetics and Epidemiology 2016 3:6
Published on: 29 July 2016
Research
Progressive retinal atrophy (PRA) belongs to a group of inherited retinal disorders associated with gradual vision impairment due to degeneration of retinal photoreceptors in various dog breeds. PRA is highly ...
Canine Genetics and Epidemiology 2016 3:7
Published on: 8 July 2016
Research
The Pug is an ancient dog breed and was the fifth most commonly registered UK pedigree breed in 2014. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory a...
Canine Genetics and Epidemiology 2016 3:5
Published on: 10 June 2016
Research
Canine patellar luxation is one of the most common orthopaedic disorders of dogs and is a potential welfare concern because it can lead to lameness, osteoarthritis and pain. However, there are limited epidemio...
Canine Genetics and Epidemiology 2016 3:4
Published on: 8 June 2016
Research
Valued for trainability in diverse tasks, dogs are the primary service animal used to assist individuals with disabilities. Despite their utility, many people in need of service dogs are sensitive to the prima...
Canine Genetics and Epidemiology 2016 3:3
Published on: 22 April 2016
Research
The morphology of dogs can provide information about their predisposition to some disorders. For example, larger breeds are predisposed to hip dysplasia and many neoplastic diseases. Therefore, longitudinal tr...
Canine Genetics and Epidemiology 2016 3:2
Published on: 5 April 2016
Research
The aims of this study were to: determine the prevalence of pectinate ligament dysplasia (PLD) in populations of Basset hounds (BH), Flatcoated retrievers (FCR) and Dandie Dinmont terriers (DDT) resident in th...
Canine Genetics and Epidemiology 2016 3:1
Published on: 12 March 2016
Research
Previous studies documented the problem of inbreeding among Italian Greyhounds (IG) from the USA and its possible role in a multiple autoimmune disease syndrome. The present study is an extension of these earl...
Canine Genetics and Epidemiology 2015 2:17
Published on: 30 October 2015
Research
Next generation sequencing (NGS) has traditionally been performed by large genome centers, but in recent years, the costs for whole-genome sequencing (WGS) have decreased substantially. With the introduction o...
Canine Genetics and Epidemiology 2015 2:16
Published on: 8 October 2015
Research
Inbreeding is inevitable in closed populations with a finite number of ancestors and where there is selection. Therefore, management of the rate of inbreeding at sustainable levels is required to avoid the ass...
Canine Genetics and Epidemiology 2015 2:13
Published on: 21 September 2015
Research
Urothelial carcinoma (UC), also known as transitional cell carcinoma (TCC), of the bladder is the most common neoplasm affecting the canine urogenital system. To facilitate study of the disease in vitro, cell lin...
Canine Genetics and Epidemiology 2015 2:15
Published on: 17 September 2015
Research
Sebaceous adenitis (SA) and Addison’s disease (AD) increased rapidly in incidence among Standard Poodles after the mid-twentieth century. Previous attempts to identify specific genetic causes using genome wide...
Canine Genetics and Epidemiology 2015 2:14
Published on: 27 August 2015
Research
Hypothyroidism is one of the most common endocrine disorders, whereas symmetrical onychomadesis is a rare claw disease in the general dog population. The aims of this study were to estimate the prevalence of h...
Canine Genetics and Epidemiology 2015 2:12
Published on: 21 August 2015
