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  1. Pugs are a brachycephalic dog breed that has become phenomenally popular over recent decades. However, there is growing concern about serious health and welfare issues in the breed. To augment the evidence-bas...

    Authors: Dan G. O’Neill, Jaya Sahota, Dave C. Brodbelt, David B. Church, Rowena M.A. Packer and Camilla Pegram
    Citation: Canine Medicine and Genetics 2022 9:4
  2. Hypoadrenocorticism is characterized by a reduction in mineralocorticoid and/or glucocorticoid production by the adrenal glands. Several subtypes have been described with different clinical and clinicopatholog...

    Authors: Pedro J. Guzmán Ramos, Michael Bennaim, Robert E. Shiel and Carmel T. Mooney
    Citation: Canine Medicine and Genetics 2022 9:6
  3. Cutaneous neoplastic diseases are the most and second-most frequently reported tumors in male and female dogs, respectively. The aims of this study were to report the occurrence of canine cutaneous tumors in a...

    Authors: Ana Luísa Martins, Ana Canadas-Sousa, João R. Mesquita, Patrícia Dias-Pereira, Irina Amorim and Fátima Gärtner
    Citation: Canine Medicine and Genetics 2022 9:2
  4. The year 2021 marked the centenary of the isolation of a therapeutic form of insulin and its successful use in dogs. This was a landmark moment that subsequently and rapidly led to the commercial manufacture o...

    Authors: Robert E. Shiel and Carmel T. Mooney
    Citation: Canine Medicine and Genetics 2022 9:1

    The Correction to this article has been published in Canine Medicine and Genetics 2022 9:3

  5. The French Bulldog is a highly popular dog breed but is linked with many serious health issues. A holistic view of breed health in French Bulldogs would assist efforts to appreciate the overall health strength...

    Authors: Dan G. O’Neill, Rowena M.A. Packer, Peter Francis, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Medicine and Genetics 2021 8:13
  6. Dog breeds are known for their distinctive body shape, size, coat color, head type and behaviors, features that are relatively similar across members of a breed. Unfortunately, dog breeds are also characterize...

    Authors: Danika Bannasch, Thomas Famula, Jonas Donner, Heidi Anderson, Leena Honkanen, Kevin Batcher, Noa Safra, Sara Thomasy and Robert Rebhun
    Citation: Canine Medicine and Genetics 2021 8:12
  7. Distichiasis is a presumed inherited eyelid disease, characterized by misplaced eyelashes. The effect on eye health and animal welfare varies between individuals; most mild cases show no clinical signs, but so...

    Authors: Kim K. L. Bellamy, Frode Lingaas and Per Madsen
    Citation: Canine Medicine and Genetics 2021 8:11
  8. A 2019 ACVIM consensus statement on diagnostics for immune-mediated hemolytic anemia (IMHA) in dogs made testing recommendations. As data on the performance of immunohematological tests was lacking, we underto...

    Authors: Nadine Idalan, Johanna O. Zeitz, Corinna N. Weber, Elisabeth Müller and Urs Giger
    Citation: Canine Medicine and Genetics 2021 8:10
  9. Osteosarcoma (OSA) is a devastating disease that is common in the Irish Wolfhound breed. The aim of this study was to use a pedigree-based approach to determine the heritability of OSA in the Irish Wolfhound u...

    Authors: Mehdi Momen, Nyah L. Kohler, Emily E. Binversie, Mariellen Dentino and Susannah J. Sample
    Citation: Canine Medicine and Genetics 2021 8:9
  10. Otitis externa is a commonly diagnosed disorder in dogs and can carry a high welfare impact on affected animals. This study aimed to report the prevalence and explore the role of breed and aural conformation a...

    Authors: Dan G. O’Neill, Andrea V. Volk, Teresa Soares, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Medicine and Genetics 2021 8:7
  11. Genetic heterogeneity of the canine angiotensin converting enzyme (ACE) gene is functionally important because the degree of aldosterone breakthrough with ACE-inhibitor therapy is greater in variant positive d...

    Authors: D. B. Adin, C. E. Atkins, S. G. Friedenberg, J. A. Stern and K. M. Meurs
    Citation: Canine Medicine and Genetics 2021 8:6
  12. Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload ...

    Authors: Eric S. Ontiveros and Joshua A. Stern
    Citation: Canine Medicine and Genetics 2021 8:4
  13. Canine idiopathic epilepsy (IE) is the most common chronic neurological brain disease in dogs, yet it can only be diagnosed by exclusion of all other potential causes. In people, epilepsy has been associated w...

    Authors: Fraje Watson, A. Augusto Coppi, Holger A. Volk, Rowena M. A. Packer, Anna Tauro and Clare Rusbridge
    Citation: Canine Medicine and Genetics 2021 8:3
  14. Osteosarcoma is an aggressive and painful bone neoplasm in dogs. Previous studies have reported epidemiological associations suggesting that large body mass, long bone length and the genetics of certain breeds...

    Authors: Grace L. Edmunds, Matthew J. Smalley, Sam Beck, Rachel J. Errington, Sara Gould, Helen Winter, Dave C. Brodbelt and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2021 8:2
  15. In people, bile acid diarrhoea is a prevalent complication of Crohn’s disease and diarrhoea-associated irritable bowel syndrome. Affected patients typically respond to bile acid sequestrants, such as cholestyr...

    Authors: L. Toresson, J. M. Steiner and J. S. Suchodolski
    Citation: Canine Medicine and Genetics 2021 8:1

    The Correction to this article has been published in Canine Medicine and Genetics 2021 8:5

  16. Approximately every fifth Dachshund is affected by disc herniation - a painful, hereditary condition which is typically preceded by disc calcification. Therefore, the selection of dogs suitable for breeding ca...

    Authors: Camilla Sichlau Bruun, Charlotte Bruun, Tine Marx, Helle Friis Proschowsky and Merete Fredholm
    Citation: Canine Medicine and Genetics 2020 7:18
  17. The Melanocortin 1 Receptor (MC1R) plays a central role in regulation of coat color determination in various species and is commonly referred to as the “E (extension) Locus”. Allelic variation of the MC1R gene is...

    Authors: Heidi Anderson, Leena Honkanen, Päivi Ruotanen, Julia Mathlin and Jonas Donner
    Citation: Canine Medicine and Genetics 2020 7:16
  18. Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, ...

    Authors: A. L. Denyer, J. P. Massey, L. J. Davison, W. E. R. Ollier, B. Catchpole and L. J. Kennedy
    Citation: Canine Medicine and Genetics 2020 7:15
  19. Inbreeding is a phenomenon that accumulates through the mating of relatives within closed populations, such as pedigree dog breeds, and results in reduced genetic variation within breeds, and may lead to poore...

    Authors: Mateja Janes, Thomas W. Lewis, Joanna J. Ilska and John A. Woolliams
    Citation: Canine Medicine and Genetics 2020 7:14
  20. The Staffordshire Bull Terrier is a popular dog breed in the UK but there is limited reliable evidence on disorder predispositions and protections within the breed. Using anonymised veterinary clinical data fr...

    Authors: Camilla Pegram, Katie Wonham, Dave C. Brodbelt, David B. Church and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2020 7:13
  21. Idiopathic epilepsy (IE) is a common neurological disorder in the domestic dog, and is defined as repeated seizure activity having no identifiable underlying cause. Some breeds, such as the Belgian shepherd do...

    Authors: J. M. Belanger, T. R. Famula, L. C. Gershony, M. K. Palij and A. M. Oberbauer
    Citation: Canine Medicine and Genetics 2020 7:12
  22. The active metabolite of vitamin D, calcitriol, has been shown across many different species to augment innate immune responses and dampen aberrant proinflammatory cytokine production. Community acquired infec...

    Authors: Jared A. Jaffey, Mariah Bessette, Zenan Tao, Nancy Bradley-Siemens and Melissa Thompson
    Citation: Canine Medicine and Genetics 2020 7:11
  23. Evidence for an autoimmune etiology in canine diabetes is inconsistent and could vary based on breed. Previous studies demonstrated that small percentages of diabetic dogs possess autoantibodies to antigens kn...

    Authors: Allison L. O’Kell, Clive H. Wasserfall, Paula S. Henthorn, Mark A. Atkinson and Rebecka S. Hess
    Citation: Canine Medicine and Genetics 2020 7:10
  24. Although, in general, cancer is considered a multifactorial disease, clustering of particular cancers in pedigrees suggests a genetic predisposition and could explain why some dog breeds appear to have an incr...

    Authors: Anna L. W. Huskey, Katie Goebel, Carlos Lloveras-Fuentes, Isaac McNeely and Nancy D. Merner
    Citation: Canine Medicine and Genetics 2020 7:8
  25. The privately owned companion dog is an emerging model in comparative medicine, notably because it shares the human environment including its risk factors, is affected by many analogous age-related diseases, r...

    Authors: Silvan R. Urfer, Matt Kaeberlein, Daniel E. L. Promislow and Kate E. Creevy
    Citation: Canine Medicine and Genetics 2020 7:7
  26. Diabetes mellitus (DM) is an important endocrine disorder of dogs. The objectives of this study were to estimate prevalence and incidence of DM in dogs, and to explore risk factors for DM and the survival of D...

    Authors: Angela M. Heeley, Dan G. O’Neill, Lucy J. Davison, David B. Church, Ellie K. Corless and Dave C. Brodbelt
    Citation: Canine Medicine and Genetics 2020 7:6
  27. Discrete breed ideals are not restricted to delimiting dog breeds from another, but also are key drivers of subpopulation differentiation. As genetic differentiation due to population fragmentation results in ...

    Authors: Sara Lampi, Jonas Donner, Heidi Anderson and Jaakko Pohjoismäki
    Citation: Canine Medicine and Genetics 2020 7:5
  28. Dogs are the most popular mammal kept as a companion animal globally. Positive human-dog relationships can benefit both the human owners as well as the dogs. However, popularity as a companion animal species d...

    Authors: Camilla L. Pegram, Brenda N. Bonnett, Helena Skarp, Gareth Arnott, Hannah James, Åke Hedhammar, Gregoire Leroy, Aimée Llewellyn-Zaidi, Ian J. Seath and Dan G. O’Neill
    Citation: Canine Medicine and Genetics 2020 7:4
  29. The calculation of demographic measures is a useful tool for evaluating the genomic architecture of dog breeds and enables ranking dog breeds in terms of genetic diversity. To achieve this for the German Dalma...

    Authors: Danae Vasiliadis, Julia Metzger and Ottmar Distl
    Citation: Canine Medicine and Genetics 2020 7:3
  30. Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the dis...

    Authors: Alisdair M. Boag, Andrea Short, Lorna J. Kennedy, Hattie Syme, Peter A. Graham and Brian Catchpole
    Citation: Canine Medicine and Genetics 2020 7:2
  31. Conditions affecting the elbow joint are a common cause of lameness in dogs. Primary-care veterinary clinical data are now recognised as a valuable research resource. Using data from the VetCompass Programme, ...

    Authors: Dan G. O’Neill, Dave C. Brodbelt, Rebecca Hodge, David B. Church and Richard L. Meeson
    Citation: Canine Medicine and Genetics 2020 7:1
  32. Atrial fibrillation (AF) is the most common arrhythmia in dogs. The Irish Wolfhound breed has a high prevalence of AF making them an ideal breed to investigate possible genetic contributions to this disease. T...

    Authors: Samantha L. Fousse, William D. Tyrrell, Mariellen E. Dentino, Frances L. Abrams, Steven L. Rosenthal and Joshua A. Stern
    Citation: Canine Genetics and Epidemiology 2019 6:11
  33. N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene. Most...

    Authors: Yumiko Uno, Shota Kawakami, Kazuhiko Ochiai and Toshinori Omi
    Citation: Canine Genetics and Epidemiology 2019 6:9
  34. In the original publication of this article [1], due to an error in a single count relating to the denominator used for this study, some of the derived values were wrong, so that abstract, plain English summar...

    Authors: Dan G. O’Neill, Zoie F. Ballantyne, Anke Hendricks, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Genetics and Epidemiology 2019 6:8

    The original article was published in Canine Genetics and Epidemiology 2019 6:7

  35. The West Highland White Terrier (WHWT) is a relatively common breed in the UK, although Kennel Club registrations have declined in recent years. The VetCompass™ Programme collates de-identified clinical data f...

    Authors: Dan G. O’Neill, Zoie F. Ballantyne, Anke Hendricks, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Genetics and Epidemiology 2019 6:7

    The Correction to this article has been published in Canine Genetics and Epidemiology 2019 6:8

  36. The greyhound is a sighthound known for its speed and agility. Greyhounds were selectively bred as functional racing animals but increasingly are kept as pets in the UK, often after their racing careers are ov...

    Authors: Dan G. O’Neill, Nicola J. Rooney, Callum Brock, David B. Church, Dave C. Brodbelt and Camilla Pegram
    Citation: Canine Genetics and Epidemiology 2019 6:4
  37. In humans, ADAMTS17 mutations are known to cause Weill-Marchesani-like syndrome, which is characterised by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Breed-specific homozygous m...

    Authors: Emily C. Jeanes, James A. C. Oliver, Sally L. Ricketts, David J. Gould and Cathryn S. Mellersh
    Citation: Canine Genetics and Epidemiology 2019 6:5
  38. Von Willebrand disorder type I (vWDI) is known as an inherited bleeding disorder in different dog breeds following an autosomal recessive inheritance. The Kromfohrländer is a rare dog breed with an increased i...

    Authors: Julia H. Segert, Jana-Marie Seidel, Walter J. Wurzer and Anja M. Geretschlaeger
    Citation: Canine Genetics and Epidemiology 2019 6:3
  39. Primary hypoadrenocorticism (Addison’s disease, AD) and symmetrical lupoid onychodystrophy (SLO) are two clinical conditions with an autoimmune etiology that occur in multiple dog breeds. In man, autoimmunity ...

    Authors: Liza C. Gershony, Janelle M. Belanger, Andrea D. Short, Myly Le, Marjo K. Hytönen, Hannes Lohi, Thomas R. Famula, Lorna J. Kennedy and Anita M. Oberbauer
    Citation: Canine Genetics and Epidemiology 2019 6:2
  40. Individual dog breeds are often reported as predisposed to specific breed-related disorders but reliable epidemiological data on disease prevalence are sparse. The Miniature Schnauzer in the UK is a popular sm...

    Authors: Dan G. O’Neill, Charlotte Butcher, David B. Church, Dave C. Brodbelt and Alex G. Gough
    Citation: Canine Genetics and Epidemiology 2019 6:1
  41. Selective breeding in populations with a limited effective population size may result in a loss of genetic diversity, which can cause an increased concentration of specific disease liability genes. The Dutch S...

    Authors: S. F. A. Keijser, H. Fieten, M. Vos-Loohuis, C. J. Piek, H. Anderson, J. Donner, I. Scholten, M. Nielen, J. W. Hesselink and F. G. van Steenbeek
    Citation: Canine Genetics and Epidemiology 2018 5:12

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