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Table 2 Allelic associations

From: Searching for "monogenic diabetes" in dogs using a candidate gene approach

     

Minor/associated allele

Frequency

Major allele

p-values

Odds ratio

 
 

Gene

CFA

Position (bp)

Annotation

 

Case

Control

 

Raw

Bonferroni

Permutation

 

95% CI

Bichon Frise

             

rs23901704

ZFP57

35

26,267,827

Syn. coding

T

0.00

0.24

C

2.58E-04

7.21E-03

4.30E-03

nc

nc

Cocker Spaniel

             

rs24305581

MTTL1

5

82,755,249

Intronic

A

0.44

0.23

G

3.73E-04

1.05E-02

1.13E-02

2.67

1.54-4.61

rs22302353

PAX4

14

8,718,207

Intronic

A

0.09

0.33

G

6.45E-06

1.81E-04

3.00E-04

0.21

0.10-0.43

rs22686871

INS

18

46,324,586

Syn. coding

G

0.00

0.13

T

7.22E-05

2.02E-03

1.90E-03

nc

nc

Miniature Dachshund

             

rs8804236

HNF4A

24

31,897,491

Syn. coding

G

0.14

0.36

A

1.45E-03

4.62E-02

4.31E-02

0.28

0.12-0.63

Samoyed

             

rs23892119

ZFP57

35

26,270,002

Intronic

C

0.11

0.00

T

1.55E-04

5.10E-03

5.50E-03

nc

nc

  1. CFA = canine chromosome number: Permutations: n=10,000: CI = confidence interval: Syn. Coding = synonymous coding SNP; nc = not calculable as one of the populations does not carry one of the alleles. Allele associations are calculated using the minor allele as a reference.