Figure 3

Genome-wide mapping reveals homozygous regions on chromosome 13 in herding dogs. Genome-wide mapping reveals homozygous regions on chromosome 13 in 26 herding dogs (BDP, Berger des Pyrenées; SD, Schapendoes) as compared to 26 pointing dogs (GM, Large Munsterlander; LW, Weimaraner). Homozygosity peaks were revealed by Homozygosity Mapper analysis in pointing dogs (A), homozygosity peaks for part of magnified chromosome 13 (B): Genome areas with homozygosity scores (HS) of >0.8 are depicted in red color. Regions with HS = 1.0 were further analysed in detail. Genotyping results for the corresponding regions are again depicted in colors for the individual dogs (C; blue = heterozygous, red = homozygous, dark shades of red indicate longer and light shorter homozygosity stretches, respectively; gray = unknown; color patterns are predefined by Homozygosity Mapper). Genotypes homozygous for the minor allele are marked with black diagonal bars. Genes included in this region are depicted as black bars including their respective abbreviated designations (D).