Table 4 DLA-haplotypes and alleles associated with hypothyroidism or protection against hypothyroidism in the Gordon setter
Total | Cases | Controls | Cases/controls | ||||||
|---|---|---|---|---|---|---|---|---|---|
DLA-haplotype or allele | % | n = 322 | % | n = 136 | % | n = 186 | OR | 95 % CI | p-value |
DRB1*00103/DQA1*00101/DQB1*00201 | 8.3 | 27 | 14.7 | 20 | 3.7 | 7 | 4.4 | 1.8 - 11.5 | 0.0005 |
DLA-DQB1*00201 | 21.4 | 69 | 33.8 | 46 | 12.4 | 23 | 3.6 | 2.1 - 6.4 | 0.000005 |
DRB1*04901/DQA1*01001/DQB1*01901 | 18.9 | 61 | 25.7 | 35 | 13.9 | 26 | 2.1 | 1.2 - 3.7 | 0.008 |
DRB1*00101/DQA1*00101/DQB1*00201 | 11.1 | 36 | 15.4 | 21 | 8.0 | 15 | 2.1 | 1.0 - 4.3 | 0.04 |
DRB1*01801/DQA1*00101/DQB1*00802 | 31.9 | 103 | 18.3 | 25 | 41.9 | 78 | 0.3 | 0.2 - 0.5 | 0.000006 |
DRB1*01501/DQA1*00601/DQB1*02301 | 5.9 | 19 | 2.2 | 3 | 8.6 | 16 | 0.2 | 0.1 - 0.8 | 0.001 |