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Table 6 Gene expression microarray results

From: A cultured approach to canine urothelial carcinoma: molecular characterization of five cell lines

Gene Location Lines differentially expressing Average fold change Gene Location Lines with relative fold change ≥2 or ≤ −2 Average fold change
CES1 a chr2 ALL −633.5 BIRC5 a chr9 In, An, Mx, K9TCC +3.6
HNMT chr19 In, Sh, Mx, K9TCC −29.6 RAF1 a chr20 ALL +4.1
DBC1 a chr11 ALL −13.6 CLU a chr25 ALL +5.5
CDKN2B a chr11 ALL −11.8 CCNG2 a chr32 ALL +6.3
FHIT a chr20 ALL −11.5 MDM2 a chr10 In, Sh, An, K9TCC +6.4
CYP2C19 a chr28 ALL −8.1 MYC a chr13 ALL +8.5
BCL2 a chr1 ALL −6.6 LAMB3 a chr7 ALL +12.4
SRPX a chrX In, An, Mx, K9TCC −6.1 TGFBR2 a chr23 ALL +12.6
FMO5 a chr17 ALL −4.9 CCND2 a chr27 ALL +14.2
SPARC a chr4 ALL −4.5 AURKA a chr24 ALL +22.2
PTEN a chr26 ALL −4 TAGLN2 a chr38 ALL +25.3
BMP7 a chr24 An, Mx, K9TCC −3.4 PTTG1 a chr4 ALL +57.5
DAPK1 a chr1 An, Mx −2.8 CDK1 a chr4 ALL +72.5
VHL a chr20 ALL −2.1 PTGS2 a chr7 ALL +76.9
  1. Numerous genes were dysregulated in the cell lines when compared to the expression profile of healthy canine urothelium. The genes listed were selected based on their magnitude of fold change, oncogenic potential, and relevance in human UC (see superscipt letter a). The specific cell lines differentially expressing each gene are listed (fold change ≥2 or ≤ −2 relative to the mean expression of two healthy urothelial samples)