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Table 2 Canine genes with exonic single nucleotide variants and percentage homology with human and mouse orthologues

From: Lumbosacral stenosis in Labrador retriever military working dogs – an exomic exploratory study

 

Dog (Canis familiaris)

Human (Homo sapiens)

Mouse (Mus musculus)

No.

Chr. No.

Ensembl predicted gene name

Chr. No.

Sequence identity (%)

E-value

Chr. No.

Sequence identity (%)

E-value

1

1

DOCK8

9

93

2 e^-90

19

88

2 e^-70

2

1

SLC7A10

19

93

1 e^-74

7

91

1 e^-69

3

1

RGS9BPa

19

81

1 e^−167

7

76

4 e^-98

4

1

TSHZ3

19

91

0

7

87

0

5

4

KIAA1279 a.k.a. KIF1BP

10

88

0

10

81

0

6

6

TFR2

7

88

5 e^-52

5

87

4 e^-37

7

7

KIF21B

1

76

2 e^−173

1

91

7 e^-79

8

7

DTL

1

92

0

1

85

0

9

7

ASXL3a

18

87

0

18

81

0

10

7

TRAPPC8

18

90

0

18

81

0

11

7

TTRa

18

94

4 e^-24

18

NA

NA

12

8

LRRC16Ba

14

90

3 e^−109

14

89

8 e^−109

13

8

ADCK1

14

93

1 e^-75

12

92

2 e^-74

14

10

ADD2 a.k.a. ADDB

2

84

3 e^−133

6

93

6 e^-55

15

11

SPOCK1

5

91

2 e^−139

13

90

3 e^-72

16

13

RNF139

8

92

0

15

91

0

17

13

TATDN1

8

86

1 e^-48

15

88

0

18

14

EEF1A1b

6

88

0

9

86

0

19

14

AGR2

7

85

2 e^-32

12

92

3 e^-19

20

14

DNAJA1b

9

89

0

4

89

0

21

14

TMEM168

7

81

0

6

88

0

22

15

CPE

4

82

0

9

88

3 e^-6

23

17

GREB1 or KIAA0575

2

86

0

12

79

3 e^-109

24

20

BSN or ZNF231

3

88

0

9

84

0

25

20

ABHD8

19

87

0

8

90

2 e^-53

26

21

FOLR2 or FBP

11

94

1 e^-73

7

81

2 e^-26

27

25

PALLD

4

84

0

8

80

3 e^-86

28

27

ABCC9

12

95

5 e^-100

6

86

2 e^-64

29

27

PTPROa

12

78

0

6

91

2 e^-41

30

32

SMARCAD1

4

92

0

6

82

0

31

34

ZBBXa

3

84

2 e^-78

3

80

2 e^-42

32

X

ZFXb

X

91

0

X

85

0

33

X

USP9X

X

93

0

X

86

0

  1. List of genes with exonic variants identified in the canine genome between the 4 LS negative and 4 LS positive Labrador retrievers in the exome sequencing study. Also listed are the percentage homologies between the canine genes (validated or predicted, according to NCBI database) and the human and mouse orthologues
  2. aDenotes genes annotated by VEP as carrying moderate impact variants
  3. bDenotes genes identified by VEP as carrying moderate impact variants but not annotated due to the uncharacterized nature of the canine gene