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Table 2 Canine genes with exonic single nucleotide variants and percentage homology with human and mouse orthologues

From: Lumbosacral stenosis in Labrador retriever military working dogs – an exomic exploratory study

  Dog (Canis familiaris) Human (Homo sapiens) Mouse (Mus musculus)
No. Chr. No. Ensembl predicted gene name Chr. No. Sequence identity (%) E-value Chr. No. Sequence identity (%) E-value
1 1 DOCK8 9 93 2 e^-90 19 88 2 e^-70
2 1 SLC7A10 19 93 1 e^-74 7 91 1 e^-69
3 1 RGS9BPa 19 81 1 e^−167 7 76 4 e^-98
4 1 TSHZ3 19 91 0 7 87 0
5 4 KIAA1279 a.k.a. KIF1BP 10 88 0 10 81 0
6 6 TFR2 7 88 5 e^-52 5 87 4 e^-37
7 7 KIF21B 1 76 2 e^−173 1 91 7 e^-79
8 7 DTL 1 92 0 1 85 0
9 7 ASXL3a 18 87 0 18 81 0
10 7 TRAPPC8 18 90 0 18 81 0
11 7 TTRa 18 94 4 e^-24 18 NA NA
12 8 LRRC16Ba 14 90 3 e^−109 14 89 8 e^−109
13 8 ADCK1 14 93 1 e^-75 12 92 2 e^-74
14 10 ADD2 a.k.a. ADDB 2 84 3 e^−133 6 93 6 e^-55
15 11 SPOCK1 5 91 2 e^−139 13 90 3 e^-72
16 13 RNF139 8 92 0 15 91 0
17 13 TATDN1 8 86 1 e^-48 15 88 0
18 14 EEF1A1b 6 88 0 9 86 0
19 14 AGR2 7 85 2 e^-32 12 92 3 e^-19
20 14 DNAJA1b 9 89 0 4 89 0
21 14 TMEM168 7 81 0 6 88 0
22 15 CPE 4 82 0 9 88 3 e^-6
23 17 GREB1 or KIAA0575 2 86 0 12 79 3 e^-109
24 20 BSN or ZNF231 3 88 0 9 84 0
25 20 ABHD8 19 87 0 8 90 2 e^-53
26 21 FOLR2 or FBP 11 94 1 e^-73 7 81 2 e^-26
27 25 PALLD 4 84 0 8 80 3 e^-86
28 27 ABCC9 12 95 5 e^-100 6 86 2 e^-64
29 27 PTPROa 12 78 0 6 91 2 e^-41
30 32 SMARCAD1 4 92 0 6 82 0
31 34 ZBBXa 3 84 2 e^-78 3 80 2 e^-42
32 X ZFXb X 91 0 X 85 0
33 X USP9X X 93 0 X 86 0
  1. List of genes with exonic variants identified in the canine genome between the 4 LS negative and 4 LS positive Labrador retrievers in the exome sequencing study. Also listed are the percentage homologies between the canine genes (validated or predicted, according to NCBI database) and the human and mouse orthologues
  2. aDenotes genes annotated by VEP as carrying moderate impact variants
  3. bDenotes genes identified by VEP as carrying moderate impact variants but not annotated due to the uncharacterized nature of the canine gene