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Table 5 Frequency, code and odds ratio (OR) for DLA class II three-locus haplotypes observed in the six studied breeds at increased risk for Addison’s disease (AD): bearded collie (61 cases, 122 controls), West Highland white terrier (WHWT; 43 cases, 166 controls), standard poodles (30 cases, 55 controls), Portuguese water dog (PWD; 17 cases, 76 controls), Labradoodle (12 cases, 9 controls) and Leonberger (11 cases, 14 controls)

From: DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

Code

DRB1

DQA1

DQB1

Breed

Control

(2n)

AD

(2n)

OR

95% CI

p-value†

1

009:01

001:01

008:02

Bearded collie

24

25

2.36

1.29–4.34

0.0058

2

015:01

006:01

003:01

Bearded collie

31

18

1.19

0.64–2.22

0.6263

3

015:01

006:01

023:01

Bearded collie

33

23

1.49

0.83–2.66

0.2177

Labradoodle

2

8

4.0

0.73–21.8

0.1466

Standard poodle

68

37

0.99

0.52–1.90

1

WHWT

17

0

N/A

  

4

018:01

001:01

002:01

Bearded collie

73

27

0.67

0.40–1.11

0.1355

WHWT

1

0

N/A

  

5

018:01

001:01

008:02

Bearded collie

70

27

0.71

0.42–1.18

0.2094

6

015:01

006:01

022:01

Bearded collie

5

2

0.80

0.15–4.17

1

Labradoodle

0

1

N/A

  

7

002:01

009:01

001:01

Bearded collie

6

0

N/A

  

Labradoodle

0

1

N/A

  

Standard poodle

2

0

N/A

  

8

023:01

003:01

005:01

Bearded Collie

1

0

N/A

  

PWD

11

5

2.21

0.71–6.84

0.1775

9

015:02

006:01

023:01

Bearded collie

1

0

N/A

  

Labradoodle

4

3

0.50

0.10–2.58

0.6786

Standard poodle

7

8

2.26

0.78–6.59

0.1586

PWD

11

5

2.21

0.71–6.84

0.1775

WHWT

4

0

N/A

  

10

015:01

006:01

020:02

WHWT

51

6

0.41

0.17–1.00

0.0514

11

013:01

001:01

002:01

Leonberger

4

4

1.22

0.27–5.59

1

Standard poodle

1

0

N/A

  

WHWT

1

0

N/A

  

12

006:01

005:01:1

007:01

Labradoodle

1

2

1.55

0.13–18.5

1

Leonberger

5

1

0.2

0.02–1.86

0.1986

Standard poodle

4

0

N/A

  

WHWT

2

0

N/A

  

13

009:01

001:01

008:01:1

Labradoodle

1

3

2.43

0.23–25.5

0.6227

Standard poodle

5

2

0.72

0.14–3.85

1

WHWT

3

2

2.61

0.43–15.88

0.5882

PWD

8

0

N/A

  

14

001:01

001:01

002:01

Labradoodle

2

2

0.73

0.09–5.72

1

Leonberger

11

16

3.64

1.07–12.30

0.0447

PWD

57

15

1.32

0.62–2.79

0.5597

WHWT

130

51

2.3

1.40–3.67

0.0009

Standard poodle

3

0

N/A

  

15

001:01

001:01

036:01

Standard poodle

2

0

N/A

  

WHWT

6

0

N/A

  

Labradoodle

0

1

N/A

  

16

001:01

009:01

001:01

WHWT

77

14

0.64

0.34–1.21

0.1886

17

008:02

003:01

004:01

PWD

59

9

0.57

0.25–1.30

0.2373

18

011:01

002:01

013:03

PWD

2

0

N/A

  

19

012:01

004:01

013:03

PWD

3

0

N/A

  

20

012:01

004:01

013–017

Standard poodle

4

0

N/A

  

21

015:01

006:01

011:01

WHWT

25

5

0.76

0.28–2.04

0.6499

22

015:01

006:01

026:01

Labradoodle

1

2

1.55

0.13–18.5

1

23

015:01

009:01

001:01

Labradoodle

3

1

0.22

0.02–2.29

0.2972

Standard poodle

8

9

2.25

0.82–6.18

0.1792

WHWT

14

6

1.70

0.63–4.57

0.3926

24

015:02

006:01

026:01

Standard poodle

0

1

N/A

  

25

015:03

006:01

023:01

Labradoodle

2

0

N/A

  

Standard poodle

4

2

0.91

0.16–5.14

1

26

016:01

001:01

002:01

Leonberger

6

1

0.16

0.02–1.44

0.1064

27

017:01

002:01

013:03

WHWT

1

0

N/A

  

28

020:01

004:01

013:03

PWD

1

0

N/A

  

Standard poodle

2

1

0.92

0.08–10.3

1

29

084:01

009:01

001:01

Labradoodle

2

0

N/A

  
  1. CI confidence interval, N/A not enough data points to calculate; †Fisher’s exact p-value, significant at p < 0.05
  2. N.B. DLA-DQB1*013–017 is short hand for DQB1*01303 and 01701 appearing on the same haplotype
  3. Bolded values were statistically significant at α = 0.05. Haplotype codes 1–9 are as used in the text, additional codes were added as needed
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Canine Medicine and Genetics

ISSN: 2662-9380