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Table 5 Frequency, code and odds ratio (OR) for DLA class II three-locus haplotypes observed in the six studied breeds at increased risk for Addison’s disease (AD): bearded collie (61 cases, 122 controls), West Highland white terrier (WHWT; 43 cases, 166 controls), standard poodles (30 cases, 55 controls), Portuguese water dog (PWD; 17 cases, 76 controls), Labradoodle (12 cases, 9 controls) and Leonberger (11 cases, 14 controls)

From: DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

Code DRB1 DQA1 DQB1 Breed Control
(2n)
AD
(2n)
OR 95% CI p-value
1 009:01 001:01 008:02 Bearded collie 24 25 2.36 1.29–4.34 0.0058
2 015:01 006:01 003:01 Bearded collie 31 18 1.19 0.64–2.22 0.6263
3 015:01 006:01 023:01 Bearded collie 33 23 1.49 0.83–2.66 0.2177
Labradoodle 2 8 4.0 0.73–21.8 0.1466
Standard poodle 68 37 0.99 0.52–1.90 1
WHWT 17 0 N/A   
4 018:01 001:01 002:01 Bearded collie 73 27 0.67 0.40–1.11 0.1355
WHWT 1 0 N/A   
5 018:01 001:01 008:02 Bearded collie 70 27 0.71 0.42–1.18 0.2094
6 015:01 006:01 022:01 Bearded collie 5 2 0.80 0.15–4.17 1
Labradoodle 0 1 N/A   
7 002:01 009:01 001:01 Bearded collie 6 0 N/A   
Labradoodle 0 1 N/A   
Standard poodle 2 0 N/A   
8 023:01 003:01 005:01 Bearded Collie 1 0 N/A   
PWD 11 5 2.21 0.71–6.84 0.1775
9 015:02 006:01 023:01 Bearded collie 1 0 N/A   
Labradoodle 4 3 0.50 0.10–2.58 0.6786
Standard poodle 7 8 2.26 0.78–6.59 0.1586
PWD 11 5 2.21 0.71–6.84 0.1775
WHWT 4 0 N/A   
10 015:01 006:01 020:02 WHWT 51 6 0.41 0.17–1.00 0.0514
11 013:01 001:01 002:01 Leonberger 4 4 1.22 0.27–5.59 1
Standard poodle 1 0 N/A   
WHWT 1 0 N/A   
12 006:01 005:01:1 007:01 Labradoodle 1 2 1.55 0.13–18.5 1
Leonberger 5 1 0.2 0.02–1.86 0.1986
Standard poodle 4 0 N/A   
WHWT 2 0 N/A   
13 009:01 001:01 008:01:1 Labradoodle 1 3 2.43 0.23–25.5 0.6227
Standard poodle 5 2 0.72 0.14–3.85 1
WHWT 3 2 2.61 0.43–15.88 0.5882
PWD 8 0 N/A   
14 001:01 001:01 002:01 Labradoodle 2 2 0.73 0.09–5.72 1
Leonberger 11 16 3.64 1.07–12.30 0.0447
PWD 57 15 1.32 0.62–2.79 0.5597
WHWT 130 51 2.3 1.40–3.67 0.0009
Standard poodle 3 0 N/A   
15 001:01 001:01 036:01 Standard poodle 2 0 N/A   
WHWT 6 0 N/A   
Labradoodle 0 1 N/A   
16 001:01 009:01 001:01 WHWT 77 14 0.64 0.34–1.21 0.1886
17 008:02 003:01 004:01 PWD 59 9 0.57 0.25–1.30 0.2373
18 011:01 002:01 013:03 PWD 2 0 N/A   
19 012:01 004:01 013:03 PWD 3 0 N/A   
20 012:01 004:01 013–017 Standard poodle 4 0 N/A   
21 015:01 006:01 011:01 WHWT 25 5 0.76 0.28–2.04 0.6499
22 015:01 006:01 026:01 Labradoodle 1 2 1.55 0.13–18.5 1
23 015:01 009:01 001:01 Labradoodle 3 1 0.22 0.02–2.29 0.2972
Standard poodle 8 9 2.25 0.82–6.18 0.1792
WHWT 14 6 1.70 0.63–4.57 0.3926
24 015:02 006:01 026:01 Standard poodle 0 1 N/A   
25 015:03 006:01 023:01 Labradoodle 2 0 N/A   
Standard poodle 4 2 0.91 0.16–5.14 1
26 016:01 001:01 002:01 Leonberger 6 1 0.16 0.02–1.44 0.1064
27 017:01 002:01 013:03 WHWT 1 0 N/A   
28 020:01 004:01 013:03 PWD 1 0 N/A   
Standard poodle 2 1 0.92 0.08–10.3 1
29 084:01 009:01 001:01 Labradoodle 2 0 N/A   
  1. CI confidence interval, N/A not enough data points to calculate; Fisher’s exact p-value, significant at p < 0.05
  2. N.B. DLA-DQB1*013–017 is short hand for DQB1*01303 and 01701 appearing on the same haplotype
  3. Bolded values were statistically significant at α = 0.05. Haplotype codes 1–9 are as used in the text, additional codes were added as needed