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Table 2 Multivariable logistic regression results for breed, and non breed-related variables significantly associated with diagnosis of osteosarcoma amongst UK dogs

From: Dog breeds and body conformations with predisposition to osteosarcoma in the UK: a case-control study

Variable Variable P-value Category OR 95% CI Category P-value
Breed < 0.001 Crossbred Base   
   Rottweiler 13.30 10.55–16.75 < 0.001
   Rhodesian Ridgeback 11.31 7.37–17.35 < 0.001
   Great Dane 10.03 5.81–17.32 < 0.001
   Mastiff (Unspecified) 9.09 6.06–13.63 < 0.001
   German Pointer 8.84 5.43–14.41 < 0.001
   Pinscher (Unspecified) 7.19 4.65–11.12 < 0.001
   Greyhound (Unspecified) 6.98 5.46–8.93 < 0.001
   Lurcher 4.94 3.57–6.83 < 0.001
   Collie (Unspecified) 3.74 1.99–7.03 < 0.001
   Golden Retriever 3.70 2.77–4.94 < 0.001
   Akita (Unspecified) 2.92 1.32–6.47 0.008
   American Bulldog 2.67 1.28–5.59 0.009
   Labrador Retriever 2.64 2.22–3.15 < 0.001
   Poodle (Unspecified) 2.48 0.87–7.00 0.088
   Boxer 2.23 1.55–3.22 < 0.001
   Standard Poodle 2.23 0.87–5.72 0.096
   Weimaraner 2.03 1.06–3.90 0.034
   German Shepherd Dog 1.96 1.47–2.62 < 0.001
   Dogue de Bordeaux 1.95 0.88–4.33 0.100
   Fox Terrier 1.75 0.64–4.74 0.274
   Labradoodle 1.62 0.97–2.72 0.066
   Hungarian Vizsla 1.52 0.58–3.99 0.395
   Scottish Terrier 1.33 0.51–3.45 0.563
   Cairn Terrier 1.24 0.55–2.84 0.603
   Alaskan Malamute 1.23 0.44–3.47 0.695
   Tibetan Terrier 1.22 0.47–3.12 0.684
   Bulldog (Unspecified) 1.17 0.42–3.27 0.758
   Whippet 1.10 0.50–2.40 0.814
   Dalmatian 1.00 0.40–2.52 0.993
   English Springer Spaniel 0.89 0.60–1.31 0.541
   Border Collie 0.82 0.55–1.22 0.324
   Other Purebred 0.78 0.65–0.93 0.006
   Staffordshire Bull Terrier 0.74 0.56–0.98 0.033
   Beagle 0.66 0.29–1.51 0.328
   Breed not recorded 0.52 0.34–0.80 0.003
   Cocker Spaniel 0.51 0.34–0.78 0.002
   West Highland White Terrier 0.50 0.32–0.80 0.004
   Husky 0.43 0.16–1.17 0.097
   Jack Russell Terrier 0.38 0.26–0.54 < 0.001
   Border Terrier 0.35 0.16–0.81 0.013
   Bichon Frise 0.30 0.14–0.64 0.002
   French Bulldog 0.30 0.11–0.83 0.020
   Cavalier King Charles Spaniel 0.21 0.10–0.46 < 0.001
   Cockapoo NA (0 cases)   
   Boston Terrier   
   Cavachon   
   Cavapoo   
   Chow Chow   
   Dachshund (Unspecified)   
   Goldendoodle   
   Jackapoo   
   Jug   
   King Charles Spaniel   
   Maltese   
   Miniature Poodle   
   Miniature Yorkshire Terrier   
   Puggle   
   Shar-Pei   
   Sprocker   
   Standard Dachshund   
Sex/Neuter status < 0.001 Female Entire Base   
   Female Neutered 7.95 5.78–10.94 < 0.001
   Male Entire 1.17 0.79–1.74 0.441
   Male Neutered 9.39 6.83–12.91 < 0.001
   Sex/Neuter unrecorded 1188.3 855.25–1651.04 < 0.001
Age (Y) < 0.001 < 3 Base   
   3 to < 6 3.64 2.82–4.70 < 0.001
   6 to < 9 13.30 10.54–16.79 < 0.001
   9 to < 12 18.44 14.59–23.30 < 0.001
   > 12 9.40 7.23–12.23 < 0.001
   Age Unrecorded 2.22 1.62–3.05 < 0.001
  1. Legend: Full multivariable logistic regression results for variables significantly associated with diagnosis of osteosarcoma amongst UK dogs. The main model included breed-name as the breed variable (Table 2), and six breed-related variables (purebred-status, Kennel Club breed group, body mass, dachshund-status, spaniel-status, chondrodystrophy status) then replaced breed-name in the model (Table 3). Cases were dogs with osteosarcoma confirmed by analysis of biopsies submitted to VPG Histology between 2008 and 2020 and controls were dogs enrolled in the VetCompass™ database during 2016