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Table 4 Breed-specific analysis (only significant haplotypes and breeds shown)

From: Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds

Breed

(n cases/n controls)

Haplotype ID

Haplotype

Cases

%

Controls

%

Odds ratio

95% Confidence interval

Protective/Risk

Number of other breeds carrying haplotype

DRB1

DQA1

DQB1

Border Terrier

(27/27)

19

015:01

006:01

020:02

7.4

27.8

0.211

0.05–0.73

Protective

6

CKCS

(48/48)

28

020:01

004:01

013:03

35.4

16.7

2.73

1.33–5.81

Risk

5

Cocker Spaniel

(55/80)

6

006:01

005:01:1

007:01

89.1

56.3

6.31

3.14–13.65

Risk

6

7

006:01

005:01:1

020:01

8.2

23.1

0.297

0.12–0.66

Protective

3

14

012:01

004:01

017:01–013:03

0.0

5.0

N/A

0–0.83

Protective

4

19

015:01

006:01

020:02

0.0

6.9

N/A

0–0.56

Protective

6

Labrador Retriever

(111/240)

1

001:01

001:01

002:01

20.3

13.8

1.59

1.02–2.47

Risk

7

WHWT

(133/150)

2

001:01

001:01

036:01

0.0

2.0

N/A

0–0.95

Protective

7

  1. DLA class II haplotypes significantly associated (upper and lower 95% confidence intervals did not cross 1) with diabetes mellitus in individual breeds, calculated using Fisher’s exact test. n = number of dogs, CKCS Cavalier King Charles Spaniel, WHWT West highland White Terrier, N/A Not applicable