Davison LJ, Herrtage ME, Catchpole B. Study of 253 dogs in the United Kingdom with diabetes mellitus. Vet Rec. 2005;156(15):467–71.
Article
CAS
PubMed
Google Scholar
Mattin M, O’Neill D, Church D, McGreevy PD, Thomson PC, Brodbelt D. An epidemiological study of diabetes mellitus in dogs attending first opinion practice in the UK. Vet Rec. 2014;174(14):349.
Article
CAS
PubMed
Google Scholar
Behrend E, Holford A, Lathan P, Rucinsky R, Schulman R. 2018 AAHA diabetes management guidelines for dogs and cats. J Am Anim Hosp Assoc. 2018;54(1):1–21.
Article
PubMed
Google Scholar
Catchpole B, Ristic JM, Fleeman LM, Davison LJ. Canine diabetes mellitus: can old dogs teach us new tricks? Diabetologia. 2005;48(10):1948–56.
Article
CAS
PubMed
Google Scholar
The mouse tumor biology database. http://tumor.informatics.jax.org/mtbwi/index.do. Accessed 20 May 2013.
Gepts W, Toussaint D. Spontaneous diabetes in dogs and cats - a pathological study. Diabetologia. 1967;3(2):249–65.
Article
CAS
PubMed
Google Scholar
Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, Hess RS, et al. Extreme beta-cell deficiency in pancreata of dogs with canine diabetes. PLoS One. 2015;10(6):1–19.
Article
CAS
Google Scholar
Todd JA. Etiology of type 1 diabetes. Immunity. 2010;32:457–67.
Article
CAS
PubMed
Google Scholar
Davison LJ, Weenink SM, Christie MR, Herrtage ME, Catchpole B. Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus. Vet Immunol Immunopathol. 2008;126(1–2):83–90.
Article
CAS
PubMed
Google Scholar
Davison LJ, Walding B, Herrtage ME, Catchpole B. Anti-insulin antibodies in diabetic dogs before and after treatment with different insulin preparations. J Vet Intern Med. 2008;22(6):1317–25.
Article
CAS
PubMed
Google Scholar
Holder AL, Kennedy LJ, Ollier WER, Catchpole B. Breed differences in development of anti-insulin antibodies in diabetic dogs and investigation of the role of dog leukocyte antigen (DLA) genes. Vet Immunol Immunopathol. 2015;167(3–4):130–8.
Article
CAS
PubMed
Google Scholar
Kim JH, Furrow E, Ritt MG, Utz PJ, Robinson WH, Yu L, et al. Anti-insulin immune responses are detectable in dogs with spontaneous diabetes. PLoS One. 2016;11(3):e0152397.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ahlgren KM, Fall T, Landegren N, Grimelius L, Von Euler H, Sundberg K, et al. Lack of evidence for a role of islet autoimmunity in the aetiology of canine diabetes mellitus. PLoS One. 2014;9(8).
Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes. 1965;14(10):619–33.
Article
CAS
PubMed
Google Scholar
Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the pancreas in type I (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia. 1986;29(5):267–74.
Article
CAS
PubMed
Google Scholar
Fleeman LM, Rand JS. Management of Canine Diabetes. Vet Clin North Am Small Anim Pract. 2001;31(5):855–80.
Article
CAS
PubMed
Google Scholar
Fall T, Hamlin HH, Hedhammar Å, Kämpe O, Egenvall A. Diabetes mellitus in a population of 180,000 insured dogs: incidence, survival, and breed distribution. J Vet Intern Med. 2007;21(6):1209–16.
Article
PubMed
Google Scholar
Yoon S, Fleeman LM, Wilson BJ, Mansfield CS, McGreevy P. Epidemiological study of dogs with diabetes mellitus attending primary care veterinary clinics in Australia. Vet Rec. 2020;187:e22.
Pociot F, Lernmark Å. Genetic risk factors for type 1 diabetes. Lancet. 2016;387(10035):2331–9.
Article
CAS
PubMed
Google Scholar
Willemsen G, Ward KJ, Bell CG, Christensen K, Bowden J, Dalgård C, et al. The concordance and heritability of type 2 diabetes in 34,166 twin pairs from international twin registers: the discordant twin (DISCOTWIN) consortium. Twin Res Hum Genet. 2015;18(6):762–71.
Article
PubMed
Google Scholar
Misra S, Owen KR. Genetics of monogenic diabetes: present clinical challenges. Curr Diab Rep. 2018;18(12):141.
Article
PubMed
PubMed Central
Google Scholar
Short AD, Catchpole B, Kennedy LJ, Barnes A, Fretwell N, Jones C, et al. Analysis of candidate susceptibility genes in canine diabetes. J Hered. 2007;98(5):518–25.
Article
CAS
PubMed
Google Scholar
Short AD, Saleh NM, Catchpole B, Kennedy LJ, Barnes A, Jones CA, et al. CTLA4 promoter polymorphisms are associated with canine diabetes mellitus. Tissue Antigens. 2010;4:242–52.
Article
CAS
Google Scholar
Short AD, Catchpole B, Kennedy LJ, Barnes A, Lee AC, Jones CA, et al. T cell cytokine gene polymorphisms in canine diabetes mellitus. Vet Immunol Immunopathol. 2009;128(1–3):137–46.
Article
CAS
PubMed
Google Scholar
Kennedy LJ, Davison LJ, Barnes A, Short AD, Fretwell N, Jones CA, et al. Identification of susceptibility and protective major histocompatibility complex haplotypes in canine diabetes mellitus. Tissue Antigens. 2006;68(6):467–76.
Article
CAS
PubMed
Google Scholar
Short AD, Holder A, Rothwell S, Massey J, Scholey R, Kennedy LJ, et al. Searching for “monogenic diabetes” in dogs using a candidate gene approach. Canine Genet Epidemiol. 2014;1(1):8.
Article
PubMed
PubMed Central
Google Scholar
Trowsdale J. The MHC, disease and selection. Immunol Lett. 2011;137(1–2):1–8.
Article
CAS
PubMed
Google Scholar
Thorsby E, Lie BA. HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms. Transpl Immunol. 2005;14(3–4 SPEC. ISS):175–82.
Article
CAS
PubMed
Google Scholar
Kennedy LJ, Quarmby S, Happ GM, Barnes A, Ramsey IK, Dixon RM, et al. Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele. Tissue Antigens. 2006;68(1):82–6.
Article
CAS
PubMed
Google Scholar
Kennedy LJ, Barnes A, Ollier WER, Day MJ. Association of a common dog leucocyte antigen class II haplotype with canine primary immune-mediated haemolytic anaemia. Tissue Antigens. 2006;68(6):502–8.
Article
CAS
PubMed
Google Scholar
Debenham SL, Hart EA, Ashurst JL, Howe KL, Quail MA, Ollier WE, Binns MM. Genomic sequence of the class II region of the canine MHC: comparison with the MHC of other mammalian species. Genomics. 2005;85:48–59.
Article
CAS
PubMed
Google Scholar
Kennedy LJ, Barnes A, Happ GM, Quinnell RJ, Bennett D, Angles JM, et al. Extensive interbreed, but minimal intrabreed, variation of DLA class II alleles and haplotypes in dogs. Tissue Antigens. 2002;59(3):194–204.
Article
CAS
PubMed
Google Scholar
Angles JM, Kennedy LJ, Pedersen NC. Frequency and distribution of alleles of canine MHC-II DLA-DQB1, DLA-DQA1 and DLA-DRB1 in 25 representative American kennel Club breeds. Tissue Antigens. 2005;66(3):173–84.
Article
CAS
PubMed
Google Scholar
Nyaga DM, Vickers MH, Jefferies C, Perry JK, O’Sullivan JM. The genetic architecture of type 1 diabetes mellitus. Mol Cell Endocrinol. 2018;477:70–80.
Article
CAS
PubMed
Google Scholar
Noble JA, Johnson J, Lane JA, Valdes AM. HLA class II genotyping of African American type 1 diabetic patients reveals associations unique to African haplotypes. Diabetes. 2013;62(9):3292–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Catchpole B, Adams JP, Holder AL, Short AD, Ollier WER, Kennedy LJ. Genetics of canine diabetes mellitus : are the diabetes susceptibility genes identified in humans involved in breed susceptibility to diabetes mellitus in dogs ? Vet J. 2013;195(2):139–47.
Article
CAS
PubMed
Google Scholar
Wagner JL, Burnett RC, DeRose SA, Storb R. Molecular analysis and polymorphism of the DLA-DQA gene. Tissue Antigens. 1996;48(3):199–204.
Article
CAS
PubMed
Google Scholar
Wagner JL, Burnett RC, Works JD, Storb R. Molecular analysis of DLA-DRB1 polymorphism. Tissue Antigens. 1996;48(5):554–61.
Article
CAS
PubMed
Google Scholar
Wagner JL, Hayes-Lattin B, Works JD, Storb R. Molecular analysis and polymorphism of the DLA-DQB genes. Tissue Antigens. 1998;52(3):242–50.
Article
CAS
PubMed
Google Scholar
Kennedy LJ, Barnes A, Short A, Brown JJ, Lester S, Seddon J, et al. Canine DLA diversity: 1. New alleles and haplotypes. Tissue Antigens. 2007;69(Suppl 1):272–88.
Article
CAS
PubMed
Google Scholar
Ziener ML, Dahlgren S, Thoresen SI, et al. Genetics and epidemiology of hypothyroidism and symmetrical onychomadesis in the Gordon setter and the English setter. Canine Genet Epidemiol. 2015;2:12.
Gershony LC, Belanger JM, Short AD, Le M, Hytönen MK, Lohi H, Famula TR, Kennedy LJ, Oberbauer AM. DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds. Canine Genet Epidemiol. 2019;6:2.
Article
PubMed
PubMed Central
Google Scholar
Boag AM, Catchpole B. A review of the genetics of hypoadrenocorticism. Top Companion Anim Med. 2014;29(4):96–101.
Article
PubMed
Google Scholar
Graham PA, Refsal KR, Nachreiner RF. Etiopathologic findings of canine hypothyroidism. Vet Clin North Am Small Anim Pract. 2007;37(4):617–31.
Article
PubMed
Google Scholar
Kennedy LJ, O’Neill T, House A, Barnes A, Kyöstilä K, Innes J, et al. Risk of anal furunculosis in German shepherd dogs is associated with the major histocompatibility complex. Tissue Antigens. 2008;71(1):51–6.
CAS
PubMed
Google Scholar
Barnes A, O’Neill T, Kennedy LJ, Short AD, Catchpole B, House A, et al. Association of canine anal furunculosis with TNFA is secondary to linkage disequilibrium with DLA-DRB1*. Tissue Antigens. 2009;73(3):218–24.
Article
CAS
PubMed
Google Scholar
Tsai S, Santamaria P. MHC class II polymorphisms, autoreactive T-cells, and autoimmunity. Front Immunol. 2013;4:321.
Article
CAS
PubMed
PubMed Central
Google Scholar
Todd JA, Bell JI, Mcdevitt HO. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature. 1987;329:599–604.
Article
CAS
PubMed
Google Scholar
Daminet S, Paradis M. Evaluation of thyroid function in dogs suffering from recurrent flank alopecia. Can Vet J. 2000;41(9):699–703.
CAS
PubMed
PubMed Central
Google Scholar
Sanchez RF, Innocent G, Mould J, Billson FM. Canine keratoconjunctivitis sicca: disease trends in a review of 229 cases. J Small Anim Pract. 2007;48(4):211–7.
Article
CAS
PubMed
Google Scholar
Klag AR, Giger U, Shofer FS. Idiopathic immune-mediated hemolytic anemia in dogs: 42 cases (1986-1990). J Am Vet Med Assoc. 1993;202(5):783–8.
CAS
PubMed
Google Scholar
Bell JS. Hereditary hypothyroidism: understanding the disease process. Tufts’ Canine and Feline Breeding and Genetics Conference; 2003.
Threlfall AJ, Boag AM, Soutter F, Glanemann B, Syme HM, Catchpole B. Analysis of DLA-DQB1 and polymorphisms in CTLA4 in cocker spaniels affected with immune-mediated haemolytic anaemia. Canine Genet Epidemiol. 2015;2(1).
Bazelle J, Aguirre-Hernandez J, Watson P, Kennedy LJ. Association between chronic pancreatitits and dog leucocyte antigen haplotypes in the English cocker spaniel. 2013 ACVIM forum research abstracts program. J Vet Intern Med. 2013;27(3):604–756.
Article
Google Scholar
Kennedy LJ, Altet L, Angles JM, Barnes A, Carter SD, Francino O, Gerlach JA, Happ GM, Ollier WE, Polvi A, Thomson W, Wagner JL. Nomenclature for factors of the dog major histocompatibility system (DLA), 1998: first report of the ISAG DLA nomenclature committee. Anim Genet. 2000;31(1):52–61.
Article
CAS
PubMed
Google Scholar
Safra N, Pedersen NC, Wolf Z, Johnson EG, Liu HW, Hughes AM, et al. Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations. Vet J. 2011;189(2):220–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Seddon JM, Berggren KT, Fleeman LM. Evolutionary history of DLA class II haplotypes in canine diabetes mellitus through single nucleotide polymorphism genotyping. Tissue Antigens. 2010;75(3):218–26.
Article
CAS
PubMed
Google Scholar
Pugliese A, Gianani R, Moromisato R, Awdeh ZL, Alper CA, Erlich HA, et al. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes. 1995;44(6):608–13.
Article
CAS
PubMed
Google Scholar
Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk analysis of the type 1 diabetes genetics consortium families. Diabetes. 2008;57(4):1084–92.
Article
CAS
PubMed
Google Scholar
Valdes G, Thomson J, Graham M, Zarghami B, Mcneney I, Kockum A, Smith M, Lathrop A, Steenkiste RJ, Dorman JS, Noble JA, Hansen AMA. D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus. Diabetologia. 2005;48:2540–3.
Article
CAS
PubMed
Google Scholar
Rotter JI, Landaw EM. Measuring the genetic contribution of a single locus to a multilocus disease. Clin Genet. 1984;26:529–42.
Article
CAS
PubMed
Google Scholar