Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds

Table 6 DLA haplotypes identified in cases and controls for the three highest-risk breeds included in the study

Haplotype ID	Haplotype			Samoyed		Tibetan Terrier		Cairn Terrier		Comment
Haplotype ID	DRB1	DQA1	DQB1	Cases % 2n = 68	Controls % 2n = 140	Cases % 2n = 40	Controls % 2n = 80	Cases % 2n = 60	Controls % 2n = 60	Comment
1	001:01	001:01	002:01			2.5	5.0	5	10	Risk haplotype in Labrador Retriever
2	001:01	001:01	036:01			17.5	11.3
4	002:01	009:01	001:01					0	3
9	009:01	001:01	008:01:1			2.5	5.0	10	13
10	009:01	001:01	008:02	23.5	17.1
12	011:01	002:01	013:03					0	2
14	012:01	004:01	017:01–013:03					0	2	Protective haplotype in combined analysis and in Cocker Spaniel
16	015:01	006:01	003:01	0	3.6			0	8	Protective haplotype in combined analysis
17	015:01	006:01	011:01	1.5	0			3	0
18	015:01	006:01	019:01–054:02	63.2	65					Unique to Samoyed
19	015:01	006:01	020:02					0	3
21	015:01	006:01	023:01			15.0	11.3	43	35
22	015:01	006:01	026:01			7.5	18.8			Unique to Tibetan Terrier
24	015:02	006:01	003:01			0.0	1.3
25	015:02	006:01	023:01	0	0.7	17.5	15.0	35	22
26	018:01	001:01	002:01					2	0
27	018:01	001:01	008:02					0	2
28	020:01	004:01	013:03	7.4	10					Risk haplotype in CKCS
30	079:01	001:01	002:01			30.0	26.3			Unique to Tibetan Terrier
	001:01	002:01	036:01			2.5	0
	015:02	006:01	054:01			2.5	0			Unique to Tibetan Terrier cases
	015:03	006:01	013:05			0	1.3			Unique to Tibetan Terrier controls
	015:03	006:01	023:01			0	1.3			Unique to Tibetan Terrier controls
	017:01	002:01	013:03					2	0
	040:01	010:01	019:01	4.4	3.6					Unique to Samoyed
	112:01	001:01	008:01:2			2.5	3.8			Unique to Tibetan Terrier

ISSN: 2662-9380