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Table 6 DLA haplotypes identified in cases and controls for the three highest-risk breeds included in the study

From: Dog leucocyte antigen (DLA) class II haplotypes and risk of canine diabetes mellitus in specific dog breeds

Haplotype ID Haplotype Samoyed Tibetan Terrier Cairn Terrier Comment
DRB1 DQA1 DQB1 Cases % 2n = 68 Controls % 2n = 140 Cases % 2n = 40 Controls % 2n = 80 Cases % 2n = 60 Controls % 2n = 60
1 001:01 001:01 002:01    2.5 5.0 5 10 Risk haplotype in Labrador Retriever
2 001:01 001:01 036:01    17.5 11.3    
4 002:01 009:01 001:01      0 3  
9 009:01 001:01 008:01:1    2.5 5.0 10 13  
10 009:01 001:01 008:02 23.5 17.1      
12 011:01 002:01 013:03      0 2  
14 012:01 004:01 017:01–013:03      0 2 Protective haplotype in combined analysis and in Cocker Spaniel
16 015:01 006:01 003:01 0 3.6    0 8 Protective haplotype in combined analysis
17 015:01 006:01 011:01 1.5 0    3 0  
18 015:01 006:01 019:01–054:02 63.2 65      Unique to Samoyed
19 015:01 006:01 020:02      0 3  
21 015:01 006:01 023:01    15.0 11.3 43 35  
22 015:01 006:01 026:01    7.5 18.8    Unique to Tibetan Terrier
24 015:02 006:01 003:01    0.0 1.3    
25 015:02 006:01 023:01 0 0.7 17.5 15.0 35 22  
26 018:01 001:01 002:01      2 0  
27 018:01 001:01 008:02      0 2  
28 020:01 004:01 013:03 7.4 10      Risk haplotype in CKCS
30 079:01 001:01 002:01    30.0 26.3    Unique to Tibetan Terrier
  001:01 002:01 036:01    2.5 0    
  015:02 006:01 054:01    2.5 0    Unique to Tibetan Terrier cases
  015:03 006:01 013:05    0 1.3    Unique to Tibetan Terrier controls
  015:03 006:01 023:01    0 1.3    Unique to Tibetan Terrier controls
  017:01 002:01 013:03      2 0  
  040:01 010:01 019:01 4.4 3.6      Unique to Samoyed
  112:01 001:01 008:01:2    2.5 3.8    Unique to Tibetan Terrier
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Canine Medicine and Genetics

ISSN: 2662-9380