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  1. Cocker spaniels are predisposed to immune-mediated haemolytic anaemia (IMHA), suggesting that genetic factors influence disease susceptibility. Dog leukocyte antigen (DLA) class II genes encode major histocomp...

    Authors: Anna J. Threlfall, Alisdair M. Boag, Francesca Soutter, Barbara Glanemann, Harriet M. Syme and Brian Catchpole
    Citation: Canine Genetics and Epidemiology 2015 2:8
  2. A Norfolk terrier was referred to the Animal Health Trust neurology department with suspected dystrophin-deficient muscular dystrophy (DD-MD), which was confirmed by clinical workup and immunohistochemistry.

    Authors: Christopher A Jenkins and Oliver P Forman
    Citation: Canine Genetics and Epidemiology 2015 2:7
  3. Working dog handlers and breeders have strong opinions on characteristics that are desirable in the breeds that they use to handle stock. Most of these characteristics are related to conformation or behaviour....

    Authors: Elizabeth R Arnott, Lincoln Peek, Jonathan B Early, Annie Y H Pan, Bianca Haase, Tracy Chew, Paul D McGreevy and Claire M Wade
    Citation: Canine Genetics and Epidemiology 2015 2:6
  4. The domestic dog represents an important model for studying the genetics of behavior. In spite of technological advances in genomics and phenomics, the genetic basis of most specific canine behaviors is largel...

    Authors: Denis A Akkad, Wanda M Gerding, Robin B Gasser and Jörg T Epplen
    Citation: Canine Genetics and Epidemiology 2015 2:5
  5. Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from...

    Authors: Jennifer F Summers, Dan G O’Neill, David B Church, Peter C Thomson, Paul D McGreevy and David C Brodbelt
    Citation: Canine Genetics and Epidemiology 2015 2:4
  6. The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnos...

    Authors: Lindsay L Farrell, Jeffrey J Schoenebeck, Pamela Wiener, Dylan N Clements and Kim M Summers
    Citation: Canine Genetics and Epidemiology 2015 2:3
  7. The breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18. Because this trait is dominant, heterozygous dogs cannot be discriminated from tho...

    Authors: Jennifer Turner Waldo and Kasandra Santana Diaz
    Citation: Canine Genetics and Epidemiology 2015 2:2
  8. Mast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk ...

    Authors: Stephanie JW Shoop, Stephanie Marlow, David B Church, Kate English, Paul D McGreevy, Anneliese J Stell, Peter C Thomson, Dan G O’Neill and David C Brodbelt
    Citation: Canine Genetics and Epidemiology 2015 2:1
  9. Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) considered to be the primary sensors of pathogens in innate immunity. Genetic variants could be associated to differences in breed innate imm...

    Authors: Anna Cuscó, Armand Sánchez, Laura Altet, Lluís Ferrer and Olga Francino
    Citation: Canine Genetics and Epidemiology 2014 1:11
  10. Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to o...

    Authors: Angela L Holder, James A Price, Jamie P Adams, Holger A Volk and Brian Catchpole
    Citation: Canine Genetics and Epidemiology 2014 1:10
  11. Syringomyelia (SM) is a painful neurological condition, prevalent in brachycephalic toy breeds including the Cavalier King Charles Spaniel (CKCS). In these breeds, SM is typically secondary to Chiari-like Malf...

    Authors: Thomas J Mitchell, Susan P Knowler, Henny van den Berg, Jane Sykes and Clare Rusbridge
    Citation: Canine Genetics and Epidemiology 2014 1:9
  12. Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenc...

    Authors: Andrea D Short, Angela Holder, Simon Rothwell, Jonathan Massey, Rachel Scholey, Lorna J Kennedy, Brian Catchpole and William ER Ollier
    Citation: Canine Genetics and Epidemiology 2014 1:8
  13. Canine behaviours that are both desirable and undesirable to owners have a demonstrable genetic component. Some behaviours are breed-specific, such as the livestock guarding by maremmas and flank sucking seen ...

    Authors: Diane van Rooy, Elizabeth R Arnott, Jonathan B Early, Paul McGreevy and Claire M Wade
    Citation: Canine Genetics and Epidemiology 2014 1:7
  14. This paper addresses the use of cohort studies in canine medicine to date and highlights the benefits of wider use of such studies in the future. Uniquely amongst observational studies, cohort studies offer th...

    Authors: Carys A Pugh, Barend M de C Bronsvoort, Ian G Handel, Kim M Summers and Dylan N Clements
    Citation: Canine Genetics and Epidemiology 2014 1:5
  15. Generalized progressive retinal atrophy (PRA) is a group of inherited eye diseases characterised by progressive retinal degeneration that ultimately leads to blindness in dogs. To date, more than 20 different ...

    Authors: Louise M Downs, Berit Wallin-Håkansson, Tomas Bergström and Cathryn S Mellersh
    Citation: Canine Genetics and Epidemiology 2014 1:4
  16. Inherited forms of eye disease are arguably the best described and best characterized of all inherited diseases in the dog, at both the clinical and molecular level and at the time of writing 29 different muta...

    Authors: Cathryn S Mellersh
    Citation: Canine Genetics and Epidemiology 2014 1:3
  17. Effective canine health surveillance systems can be used to monitor disease in the general population, prioritise disorders for strategic control and focus clinical research, and to evaluate the success of the...

    Authors: Dan G O’Neill, David B Church, Paul D McGreevy, Peter C Thomson and Dave C Brodbelt
    Citation: Canine Genetics and Epidemiology 2014 1:2

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