Wayne RK, Leonard JA, Vila C. Genetic analysis of dog domestication. In: Zeder MA, editor. Documenting domestication: new genetic and archaeological paradigms. Berkeley, California: University of California Press; 2006. p. 279–93.
Spady TC, Ostrander EA. Canine behavioral genetics: pointing out the phenotypes and herding up the genes. Am J Hum Genet. 2008;82(1):10–8.
Vaysse A, Ratnakumar A, Derrien T, Axelsson E, Rosengren Pielberg G, Sigurdsson S, et al. Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLoS Genet. 2011;7(10):e1002316.
Wiles BM, Llewellyn-Zaidi AM, Evans KM, O'Neill DG, Lewis TW. Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds. Canine Genet Epidemiol. 2017;4(1):8.
Gough A, Thomas A, O'Neill D. Breed predispositions to disease in dogs and cats. 3rd ed. Chichester, West Sussex: Wiley-Blackwell; 2018. p. 398.
O'Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Prevalence of disorders recorded in dogs attending primary-care veterinary practices in England. PLoS One. 2014;9(3):1–16.
O'Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Longevity and mortality of owned dogs in England. Vet J. 2013;198(3):638–43.
Patronek GJ, Waters DJ, Glickman LT. Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol. 1997;52(3):B171–B8.
Adams VJ, Evans KM, Sampson J, Wood JLN. Methods and mortality results of a health survey of purebred dogs in the UK. J Small Anim Pract. 2010;51(10):512–24.
Proschowsky HF, Rugbjerg H, Ersbøll AK. Mortality of purebred and mixed-breed dogs in Denmark. Prev Vet Med. 2003;58(1–2):63–74.
Bateson P. Independent inquiry into dog breeding. Cambridge: University of Cambridge; 2010.
O'Neill DG, Coulson NR, Church DB, Brodbelt DC. Demography and disorders of German shepherd dogs under primary veterinary care in the UK. Canine Genet Epidemiol. 2017;4(1):7.
O'Neill DG, Seah WY, Church DB, Brodbelt DC. Rottweilers under primary veterinary care in the UK: demography, mortality and disorders. Canine Genet Epidemiol. 2017;4(1):13.
O'Neill DG, Darwent EC, Church DB, Brodbelt DC. Border terriers under primary veterinary care in England: demography and disorders. Canine Genet Epidemiol. 2017;4(1):15.
O'Neill D, Church D, McGreevy P, Thomson P, Brodbelt DC. Approaches to canine health surveillance. Canine Genet Epidemiol. 2014;1(1):2.
Bonnett BN, Egenvall A. Age patterns of disease and death in insured Swedish dogs, cats and horses. J Comp Pathol. 2010;142(Supplement 1):S33–S8.
Bonnett BN, Egenvall A, Hedhammar Å, Olson P. Mortality in over 350,000 insured Swedish dogs from 1995–2000: I. breed-, gender-, age- and cause-specific rates. Acta Vet Scand. 2005;46(3):105–20.
Egenvall A, Bonnett BN, Hedhammar A, Olson P. Mortality in over 350,000 insured Swedish dogs from 1995-2000: II. breed-specific age and survival patterns and relative risk for causes of death. Acta Vet Scand. 2005;46(3):121–36.
Egenvall A, Nødtvedt A, Penell J, Gunnarsson L, Bonnett BN. Insurance data for research in companion animals: benefits and limitations. Acta Vet Scand. 2009;51:42.
Egenvall A, Bonnett BN, Olson P, Hedhammar Å. Validation of computerized Swedish dog and cat insurance data against veterinary practice records. Prev Vet Med. 1998;36(1):51–65.
The VeNom Coding Group. VeNom Veterinary Nomenclature [http://www.venomcoding.org].
R: A language and environment for statistical computing [Internet]. 2018 [cited July 1st, 2018]. Available from: http://www.R-project.org/.
Inc. TM. MATLAB and statistics toolbox release 2012b. Natick, Massachusetts, United States: The MathWorks Inc.; 2018.
Newcombe RG. Two-sided confidence intervals for the single proportion: comparison of seven methods. Stat Med. 1998;17(8):857–72.
Aickin M, Gensler H. Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods. Am J Public Health. 1996;86:726–8.
Kirkwood BR, Sterne JAC. Essential medical statistics. 2nd ed. Oxford: Blackwell Science; 2003.
Chambers JM, Cleveland WM, Kleiner B, Tukey PA. Comparing data distributions. In graphical methods for data analysis, 62. Belmont, California: Wadsworth International Group; 1983. isbn:087150-413-8.
The Kennel Club. The Kennel Club’s Breed Health and Conservation Plans project. https://www.thekennelclub.org.uk/health/breed-health-and-conservation-plans/.
Trapp SM, Iacuzio AI, Barca Junior FA, Kemper B, Silva LCD, Okano W, Tanaka NM, Grecco FCDAR, Cunha Filho LFCD, Sterza FDAM. Causes of death and reasons for euthanasia in a hospital population of dogs and cats. Braz J Vet Res Anim Sci. 2010;47:395–402.
Rollin BE. Euthanasia and quality of life. J Am Vet Med Assoc. 2006;228:1014–6.
Jagoe A, Serpell J. Owner characteristics and interactions and the prevalence of canine behaviour problems. Appl Anim Behav Sci. 1996;47(1/2):31–42.
Boyd C, Jarvis S, McGreevy PD, Heath S, Church DB, Brodbelt DC, O'Neill DG. Mortality resulting from undesirable behaviours in dogs aged under three years attending primary-care veterinary practices in England. Anim Welf. 2018;27:251–62.
Davis H, Irwin P, Richardson M, O'Brien-Malone A. When a pet dies: religious issues, euthanasia and strategies for coping with bereavement. Anthrozoos. 2003;16(1):57–74.
Reynolds CA, Oyama MA, Rush JE, Rozanski EA, Singletary GE, Brown DC, et al. Perceptions of quality of life and priorities of owners of cats with heart disease. J Vet Intern Med. 2010;24(6):1421–6.
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, et al. Metformin improves healthspan and lifespan in mice. Nat Commun. 2013;4:2192.
Creevy KE, Austad SN, Hoffman JM, O'Neill DG, Promislow DEL. The companion dog as a model for the longevity dividend. Cold Spring Harb Perspect Med. 2016;6(1):a026633.
Yeates JW, Main DCJ. Veterinary opinions on refusing euthanasia: justifications and philosophical frameworks. Vet Rec. 2011;168(10):263.
Yeates J. Ethical aspects of euthanasia of owned animals. Practice. 2010;32(2):70–3.
Tzivian L, Friger M, Kushnir T. Associations between stress and quality of life: differences between owners keeping a living dog or losing a dog by euthanasia. PLoS One. 2015;10(3):e0121081.
Galis F, Van Der Sluijs I, Van Dooren TJM, Metz JAJ, Nussbaumer M. Do large dogs die young? J Exp Zool B Mol Dev Evol. 2007;308B(2):119–26.
Mattin MJ, Boswood A, Church DB, López-Alvarez J, McGreevy PD, O'Neill DG, et al. Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in England. J Vet Intern Med. 2015;29(3):847–54.
Summers J, O'Neill D, Church D, Thomson P, McGreevy P, Brodbelt D. Prevalence of disorders recorded in cavalier King Charles spaniels attending primary-care veterinary practices in England. Canine Genet Epidemiol. 2015;2(1):4.
Constantino-Casas F, Mayhew D, Hoather TM, Dobson JM. The clinical presentation and Histopathologic–Immunohistochemical classification of Histiocytic sarcomas in the flat coated retriever. Vet Pathol Online. 2011;48(3):764–71.
Dobson J, Hoather T, McKinley TJ, Wood JL. Mortality in a cohort of flat-coated retrievers in the UK. Vet Comp Oncol. 2009;7(2):115–21.
Egenvall A, Nodtvedt A, von Euler H. Bone tumors in a population of 400 000 insured Swedish dogs up to 10 y of age: incidence and survival. Can J Vet Res. 2007;71(4):292–9.
O'Neill DG, Case J, Boag AK, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Gastric dilation-volvulus in dogs attending UK emergency-care veterinary practices: prevalence, risk factors and survival. J Small Anim Pract. 2017;58:629–38.
Glickman LT. Incidence of and breed-related risk factors for gastric dilatation-volvulus in dogs. J Am Vet Med Assoc. 2000;216:40–5.
Martin MWS, Stafford Johnson MJ, Celona B. Canine dilated cardiomyopathy: a retrospective study of signalment, presentation and clinical findings in 369 cases. J Small Anim Pract. 2009;50:23–9.
Mattin MJ, Boswood A, Church DB, López-Alvarez J, McGreevy PD, O'Neill DG, Thomson PC, Brodbelt DC. Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in England. J Vet Intern Med. 2015;29:847–54.
Rosenberger JA, Pablo NV, Crawford PC. Prevalence of and intrinsic risk factors for appendicular osteosarcoma in dogs: 179 cases (1996-2005). J Am Vet Med Assoc. 2007;231:1076–80.
Dohoo I, Martin W, Stryhn H. Veterinary epidemiologic research. 2nd ed. Charlottetown: VER Inc; 2009.
Scott A, Jeon S-H, Joyce CM, Humphreys JS, Kalb G, Witt J, et al. A randomised trial and economic evaluation of the effect of response mode on response rate, response bias, and item non-response in a survey of doctors. BMC Med Res Methodol. 2011;11(1):126.
Vrac M, Friederichs P. Multivariate - Intervariable, spatial, and temporal Bias correction. J Clim. 2014;28(1):218–37.
Boakes EH, McGowan PJK, Fuller RA, Chang-qing D, Clark NE, O'Connor K, et al. Distorted views of biodiversity: spatial and temporal Bias in species occurrence data. PLoS Biol. 2010;8(6):e1000385.
Urfer SR. Bias in canine lifespan estimates through right censored data. J Small Anim Pract. 2011;52(10):555.
Urfer SR. Right censored data (‘cohort bias’) in veterinary life span studies. Vet Rec. 2008;163(15):457–8.
The Kennel Club. Breed registration statistics [http://www.thekennelclub.org.uk/registration/breed-registration-statistics/].