Gum GG, MacKay EO. Physiology of the Eye. In: Gelatt KN, Gilger BC, Kern TJ, editors. Veterinary ophthalmology, vol. 1. 5th ed. Oxford: Wiley-Blackwell; 2013. p. 171–207.
Google Scholar
Ollivier FJ, Gilger BC, Barrie KP, Kallberg ME, Plummer CE, O’Reilly S, et al. Proteinases of the cornea and preocular tear film. Vet Ophthalmol. 2007;10(4):199–206.
Article
CAS
PubMed
Google Scholar
Ledbetter EC, Gilger BC. Diseases and surgery of the canine cornea and sclera. In: Gelatt KN, Gilger BC, Kern TJ, editors. Veterinary ophthalmology, vol. 2. 5th ed. Oxford: Wiley-Blackwell; 2013. p. 976–1049.
Google Scholar
Rooney NJ, Sargan DR. Welfare concerns associated with pedigree dog breeding in the UK. Anim Welfare. 2010;19:133–40.
CAS
Google Scholar
Stanley RG, Hardman C, Johnson BW. Results of grid keratotomy, superficial keratectomy and debridement for the management of persistent corneal erosions in 92 dogs. Vet Ophthalmol. 1998;1(4):233–8.
Article
PubMed
Google Scholar
Murphy CJ, Marfurt CF, McDermott A, Bentley E, Abrams GA, Reid TW, et al. Spontaneous chronic corneal epithelial defects (SCCED) in dogs: clinical features, innervation, and effect of topical SP, with or without IGF-1. Investig Ophthalmol Vis Sci. 2001;42(10):2252–61.
CAS
Google Scholar
Sanchez RF, Innocent G, Mould J, Billson FM. Canine keratoconjunctivitis sicca: disease trends in a review of 229 cases. J Small Anim Pract. 2007;48(4):211–7.
Article
CAS
PubMed
Google Scholar
Krecny M, Tichy A, Rushton J, Nell B. A retrospective survey of ocular abnormalities in pugs: 130 cases. J Small Anim Pract. 2015;56(2):96–102.
Article
CAS
PubMed
Google Scholar
Dorbandt DM, Moore PA, Myrna KE. Outcome of conjunctival flap repair for corneal defects with and without an acellular submucosa implant in 73 canine eyes. Vet Ophthalmol. 2015;18(2):116–22.
Article
PubMed
Google Scholar
Dawson C, Naranjo C, Sanchez‐Maldonado B, Fricker GV, Linn‐Pearl RN, Escanilla N, et al. Immediate effects of diamond burr debridement in patients with spontaneous chronic corneal epithelial defects, light and electron microscopic evaluation. Vet Ophthalmol. 2015;1–5.
Bartlett PC, Van Buren JW, Neterer M, Zhou C. Disease surveillance and referral bias in the veterinary medical database. Prev Vet Med. 2010;94(3–4):264–71.
Article
PubMed
Google Scholar
McGreevy PD, Nicholas FW. Some practical solutions to welfare problems in dog breeding. Anim Welfare. 1999;8:329–41.
Google Scholar
Bateson P. Independent inquiry into dog breeding. Cambridge: University of Cambridge; 2010.
Google Scholar
Collins LM, Asher L, Summers J, McGreevy P. Getting priorities straight: risk assessment and decision-making in the improvement of inherited disorders in pedigree dogs. Vet J. 2011;189(2):147–54.
Article
PubMed
Google Scholar
Sanchez RF. Chapter 12: the cornea. In: Gould D, McLellan GJ, editors. BSAVA manual of canine and feline ophthalmology. 3rd ed. London: BSAVA; 2014.
Google Scholar
Bentley E, Abrams GA, Covitz D, Cook CS, Fischer CA, Hacker D, et al. Morphology and immunohistochemistry of spontaneous chronic corneal epithelial defects (scced) in dogs. Investig Ophthalmol Vis Sci. 2001;42(10):2262–9.
CAS
Google Scholar
Gervais KJ, Pirie CG, Ledbetter EC, Pizzirani S. Acute primary canine herpesvirus-1 dendritic ulcerative keratitis in an adult dog. Vet Ophthalmol. 2012;15(2):133–8.
Article
PubMed
Google Scholar
Van Der Woerdt A. Adnexal surgery in dogs and cats. Vet Ophthalmol. 2004;7(5):284–90.
Article
PubMed
Google Scholar
Read RA, Broun HC. Entropion correction in dogs and cats using a combination Hotz–Celsus and lateral eyelid wedge resection: results in 311 eyes. Vet Ophthalmol. 2007;10(1):6–11.
Article
PubMed
Google Scholar
D’Anna N, Sapienza JS, Guandalini A, Guerriero A. Use of a dermal biopsy punch for removal of ectopic cilia in dogs: 19 cases. Vet Ophthalmol. 2007;10(1):65–7.
Article
PubMed
Google Scholar
Sansom J. Keratoconjunctivitis sicca in the dog: a review of two hundred cases. J Small Anim Pract. 1985;26(3):121–31.
Article
Google Scholar
Sansom J, Blunden T. Calcareous degeneration of the canine cornea. Vet Ophthalmol. 2010;13(4):238–43.
Article
PubMed
Google Scholar
Christmas R. Management of chemical burns of the canine cornea. Can Vet J. 1991;32(10):608–12.
CAS
PubMed
PubMed Central
Google Scholar
Vanore M, Chahory S, Payen G, Clerc B. Surgical repair of deep melting ulcers with porcine small intestinal submucosa (SIS) graft in dogs and cats. Vet Ophthalmol. 2007;10(2):93–9.
Article
PubMed
Google Scholar
Paulsen ME, Kass PH. Traumatic corneal laceration with associated lens capsule disruption: a retrospective study of 77 clinical cases from 1999 to 2009. Vet Ophthalmol. 2012;15(6):355–68.
Article
PubMed
Google Scholar
Dawson C, Sanchez RF. A prospective study of the prevalence of corneal surface disease in dogs receiving prophylactic topical lubrication under general anesthesia. Vet Ophthalmol. 2016;19(2):124–9.
Article
PubMed
Google Scholar
Spivack RE, Elkins AD, Moore GE, Lantz GC. Postoperative complications following TECA-LBO in the Dog and Cat. J Am Anim Hosp Assoc. 2013;49(3):160–8.
Article
PubMed
Google Scholar
Attali-Soussay K, Jegou J-P, Clerc B. Retrobulbar tumors in dogs and cats: 25 cases. Vet Ophthalmol. 2001;4(1):19–27.
Article
CAS
PubMed
Google Scholar
van der Woerdt A. Orbital inflammatory disease and pseudotumor in dogs and cats. Vet Clin N Am Small Anim Pract. 2008;38(2):389–401.
Article
Google Scholar
Gough A, Thomas A. Breed predispositions to disease in dogs and cats. 2nd ed. Chicester: Wiley-Blackwell; 2010.
Google Scholar
Packer RMA, Hendricks A, Burn CC. Impact of facial conformation on canine health: corneal ulceration. PLoS ONE. 2015;10(5):1–16.
Article
Google Scholar
Tolar EL, Hendrix DVH, Rohrbach BW, Plummer CE, Brooks DE, Gelatt KN. Evaluation of clinical characteristics and bacterial isolates in dogs with bacterial keratitis: 97 cases (1993–2003). J Am Vet Med Assoc. 2006;228(1):80–5.
Article
PubMed
Google Scholar
Tetas Pont R, Matas Riera M, Newton R, Donaldson D. Corneal and anterior segment foreign body trauma in dogs: a review of 218 cases. Vet Ophthalmol. 2015;19(5):386–97.
Article
PubMed
Google Scholar
O’Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Prevalence of disorders recorded in dogs attending primary-care veterinary practices in England. PLoS ONE. 2014;9(3):1–16.
Google Scholar
The VeNom Coding Group. VeNom Veterinary Nomenclature [http://www.venomcoding.org]. Accessed 12 May 2017.
O’Neill DG, Scudder C, Faire JM, Church DB, McGreevy PD, Thomson PC, et al. Epidemiology of hyperadrenocorticism among 210,824 dogs attending primary-care veterinary practices in the UK from 2009 to 2014. J Small Anim Pract. 2016;57(7):365–73.
Article
PubMed
Google Scholar
Pearce N. Classification of epidemiological study designs. Int J Epidemiol. 2012;41(2):393–7.
Article
PubMed
Google Scholar
Epi Info 7 CDC. Centers for Disease Control and Prevention (US): Introducing Epi Info 7 [http://wwwn.cdc.gov/epiinfo/7]. Accessed 12 May 2017.
Irion DN, Schaffer AL, Famula TR, Eggleston ML, Hughes SS, Pedersen NC. Analysis of genetic variation in 28 dog breed populations with 100 microsatellite markers. J Hered. 2003;94(1):81–7.
Article
CAS
PubMed
Google Scholar
Scott M, Flaherty D, Currall J. Statistics: how many? J Small Anim Pract. 2012;53(7):372–6.
Article
CAS
PubMed
Google Scholar
Packer RMA, Hendricks A, Tivers MS, Burn CC. Impact of facial conformation on canine health: brachycephalic obstructive airway syndrome. PLoS ONE. 2015;10(10):e0137496.
Article
PubMed
PubMed Central
Google Scholar
Crane C, Rozanski EA, Abelson AL, de Laforcade A. Severe brachycephalic obstructive airway syndrome is associated with hypercoagulability in dogs. J Vet Diagn Investig. 2017;1040638717703434. doi: https://doi.org/10.1177/1040638717703434.
Caccamo R, Buracco P, La Rosa G, Cantatore M, Romussi S. Glottic and skull indices in canine brachycephalic airway obstructive syndrome. BMC Vet Res. 2014;10(1):12.
Article
PubMed
PubMed Central
Google Scholar
Georgevsky D, Carrasco JJ, Valenzuela M, McGreevy PD. Domestic dog skull diversity across breeds, breed groupings, and genetic clusters. J Vet Behav Clin Appl Res. 2014;9(5):228–34.
Article
Google Scholar
The Kennel Club. Breed Information Centre [http://www.thekennelclub.org.uk/services/public/breed/]. Accessed 12 May 2017.
Kirkwood BR, Sterne JAC. Essential medical statistics. 2nd ed. Oxford: Blackwell Science; 2003.
Google Scholar
Dohoo I, Martin W, Stryhn H. Veterinary epidemiologic research. 2nd ed. Charlottetown: VER Inc; 2009.
Google Scholar
O’Neill D, Church D, McGreevy P, Thomson P, Brodbelt D. Approaches to canine health surveillance. Canine Genet Epidemiol. 2014;1(1):2.
Article
PubMed
PubMed Central
Google Scholar
Lacerda RP, Peña Gimenez MT, Laguna F, Costa D, Ríos J, Leiva M. Corneal grafting for the treatment of full-thickness corneal defects in dogs: a review of 50 cases. Vet Ophthalmol. 2016;1–10.
Barrett P, Scagliotti R, Merideth R, Jackson P, Alarcon F. Absolute corneal sensitivity and corneal trigeminal nerve anatomy in normal dogs. Prog Vet Comp Ophthalmol. 1991;1(4):245–54.
Google Scholar
Blocker T, Van Der Woerdt A. A comparison of corneal sensitivity between brachycephalic and Domestic Short-haired cats. Vet Ophthalmol. 2001;4(2):127–30.
Article
CAS
PubMed
Google Scholar
Cavanagh HD, Colley AM. The molecular basis of neurotrophic keratitis. Acta Ophthalmol. 1989;67(S192):115–34.
Article
Google Scholar
Touhami A, Grueterich M, Tseng SCG. The role of ngf signaling in human limbal epithelium expanded by amniotic membrane culture. Investig Ophthalmol Vis Sci. 2002;43(4):987–94.
Google Scholar
Yamada N, Yanai R, Inui M, Nishida T. Sensitizing effect of Substance P on corneal epithelial migration induced by IGF-1, fibronectin, or interleukin-6. Investig Ophthalmol Vis Sci. 2005;46(3):833–9.
Article
Google Scholar
Ueno H, Ferrari G, Hattori T, Saban DR, Katikireddy KR, Chauhan SK, et al. Dependence of corneal stem/progenitor cells on ocular surface innervation. Investig Ophthalmol Vis Sci. 2012;53(2):867–72.
Article
CAS
Google Scholar
Luesma MJ, Gherghiceanu M, Popescu LM. Telocytes and stem cells in limbus and uvea of mouse eye. J Cell Mol Med. 2013;17(8):1016–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
McGreevy P, Grassi TD, Harman AM. A strong correlation exists between the distribution of retinal ganglion cells and nose length in the dog. Brain Behav Evol. 2004;63(1):13–22.
Article
PubMed
Google Scholar
Maggs DJ, Miller PE, Ofri R, Slatter DHFovo. Slatter’s fundamentals of veterinary ophthalmology. 4th ed. Philadelphia; London: Elsevier Saunders; 2008.
Google Scholar
O’Neill DG, Darwent EC, Church DB, Brodbelt DC. Demography and health of Pugs under primary veterinary care in England. Canine Genet Epidemiol. 2016;3(1):1–12.
Article
Google Scholar
Sanchez RF, Dawson C, Matas Riera M, Escanilla N. Preliminary results of a prospective study of inter‐and intra‐user variability of the Royal Veterinary College corneal clarity score (RVC‐CCS) for use in veterinary practice. Vet Ophthalmol. 2016;19(4):313–8.
Article
PubMed
Google Scholar
Collins LM, Asher L, Summers JF, Diesel G, McGreevy PD. Welfare epidemiology as a tool to assess the welfare impact of inherited defects on the pedigree dog population. Anim Welfare. 2010;19:67–75.
CAS
Google Scholar
Hansen BD. Assessment of pain in dogs: veterinary clinical studies. ILAR J. 2003;44(3):197–205.
Article
CAS
PubMed
Google Scholar
Holton LL, Scott EM, Nolan AM, Reid J, Welsh E, Flaherty D. Comparison of three methods used for assessment of pain in dogs. J Am Vet Med Assoc. 1998;212(1):61–6.
CAS
PubMed
Google Scholar
Firth AM, Haldane SL. Development of a scale to evaluate postoperative pain in dogs. J Am Vet Med Assoc. 1999;214(5):651–9.
CAS
PubMed
Google Scholar
Holton L, Reid J, Scott EM, Pawson P, Nolan A. Development of a behaviour-based scale to measure acute pain in dogs. The Veterinary Record. 2001;148(17):525–31.
Article
CAS
PubMed
Google Scholar
Paul ES, Harding EJ, Mendl M. Measuring emotional processes in animals: the utility of a cognitive approach. Neurosci Biobehav Rev. 2005;29(3):469–91.
Article
PubMed
Google Scholar
Gelatt KN. Veterinary ophthalmology: our past, present and future. Bulletin de l’Academie Veterinaire de France. 2008;161(4):299–306.
Article
Google Scholar
Taylor-Brown FE, Meeson RL, Brodbelt DC, Church DB, McGreevy PD, Thomson PC, et al. Epidemiology of cranial cruciate ligament disease diagnosis in dogs attending primary-care veterinary practices in England. Vet Surg. 2015;44(6):777–83.
Article
PubMed
Google Scholar
Shoop S, Marlow S, Church D, English K, McGreevy P, Stell A, et al. Prevalence and risk factors for mast cell tumours in dogs in England. Canine Genet Epidemiol. 2015;2(1):1.
Article
CAS
PubMed
PubMed Central
Google Scholar
O’Neill DG, Elliott J, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Chronic kidney disease in dogs in UK veterinary practices: prevalence, risk factors, and survival. J Vet Intern Med. 2013;27(4):814–21.
Article
PubMed
Google Scholar
O’Neill DG, Meeson RL, Sheridan A, Church DB, Brodbelt DC. The epidemiology of patellar luxation in dogs attending primary-care veterinary practices in England. Canine Genet Epidemiol. 2016;3(1):1–12.
Article
Google Scholar
Egenvall A, Nødtvedt A, Penell J, Gunnarsson L, Bonnett BN. Insurance data for research in companion animals: benefits and limitations. Acta Vet Scand. 2009;51:42.
Article
PubMed
PubMed Central
Google Scholar
Shore ER, Douglas DK, Riley ML. What’s in it for the companion animal? Pet attachment and college students’ behaviors toward pets. J Appl Anim Welf Sci. 2005;8(1):1–11.
Article
CAS
PubMed
Google Scholar
Mattin MJ, Boswood A, Church DB, López-Alvarez J, McGreevy PD, O’Neill DG, et al. Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in England. J Vet Intern Med. 2015;29(3):847–54.
Article
CAS
PubMed
PubMed Central
Google Scholar