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Canine Genetics and Epidemiology

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  1. Content type: Research

    Pure breeding of dogs has led to over 700 heritable disorders, of which almost 300 are Mendelian in nature. Seventy percent of the characterized mutations have an autosomal recessive mode of inheritance, indic...

    Authors: Niels C. Pedersen, Bonnie Shope and Hongwei Liu

    Citation: Canine Genetics and Epidemiology 2017 4:11

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  2. Content type: Research

    Rottweilers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commonly reco...

    Authors: Dan G. O’Neill, Wee Yin Seah, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2017 4:13

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  3. Content type: Research

    Studying cancer and other diseases poses a problem due to their protracted and multifactorial nature. Prospective studies are useful to investigate chronic disease processes since collection of lifestyle infor...

    Authors: Melissa Simpson, Erin Searfoss, Sharon Albright, Diane E. Brown, Barbara Wolfe, Nancy K. Clark, Susan E. McCann, David Haworth, Mike Guy and Rod Page

    Citation: Canine Genetics and Epidemiology 2017 4:14

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  4. Content type: Research

    Canine lumbosacral stenosis is defined as narrowing of the caudal lumbar and/or sacral vertebral canal. A risk factor for neurologic problems in many large sized breeds, lumbosacral stenosis can also cause ear...

    Authors: Meenakshi Mukherjee, Jeryl C. Jones and Jianbo Yao

    Citation: Canine Genetics and Epidemiology 2017 4:12

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  5. Content type: Research

    Genetic polymorphisms within the glutathione S-transferase P1 (GSTP1) gene affect the elimination of toxic xenobiotics by the GSTP1 enzyme. In dogs, exposure to environmental chemicals that may be GSTP1 substrate...

    Authors: James Sacco, Sarah Mann and Keller Toral

    Citation: Canine Genetics and Epidemiology 2017 4:9

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  6. Content type: Research

    Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features. However, few studies empiric...

    Authors: B. M. Wiles, A. M. Llewellyn-Zaidi, K.M. Evans, D. G. O’Neill and T. W. Lewis

    Citation: Canine Genetics and Epidemiology 2017 4:8

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  7. Content type: Research

    The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are no...

    Authors: Dan G. O’Neill, Noel R. Coulson, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2017 4:7

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  8. Content type: Research

    Corneal ulcerative disease (CUD) has the potential to adversely affect animal welfare by interfering with vision and causing pain. The study aimed to investigate for the first time the prevalence, breed-based ...

    Authors: Dan G. O’Neill, Monica M. Lee, Dave C. Brodbelt, David B. Church and Rick F. Sanchez

    Citation: Canine Genetics and Epidemiology 2017 4:5

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  9. Content type: Research

    Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of...

    Authors: Janelle M. Belanger, Thomas P. Bellumori, Danika L. Bannasch, Thomas R. Famula and Anita M. Oberbauer

    Citation: Canine Genetics and Epidemiology 2017 4:6

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  10. Content type: Research

    Concentrated breeding effort to produce various body structures and behaviors of dogs to suit human demand has inadvertently produced unwanted traits and diseases that accompany the morphological and behaviora...

    Authors: Mark J. Fealey, Joy Li, Rebel J. E. Todhunter, Ursula Krotscheck, Kei Hayashi, Marina J. McConkey, Adam R. Boyko, Jessica J. Hayward and Rory J. Todhunter

    Citation: Canine Genetics and Epidemiology 2017 4:4

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  11. Content type: Research

    Osteosarcoma is the most common neoplastic disease in Scottish Deerhounds. For Deerhounds, a 2007 population-based study concluded that a single dominant genetic factor largely governed disease risk. For Greyh...

    Authors: John E. Dillberger and Sara Ann McAtee

    Citation: Canine Genetics and Epidemiology 2017 4:3

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  12. Content type: Research

    Exercise-induced collapse (EIC) due to DNM1 mutation and rupture of the cranial cruciate ligament are both common syndromes in the Labrador retriever breed. A cohort of 313 Labradors was recruited based on their ...

    Authors: Kari J Ekenstedt, Katie M Minor, Aaron K Rendahl and Michael G Conzemius

    Citation: Canine Genetics and Epidemiology 2017 4:2

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  13. Content type: Research

    In humans, reduced activity of the enzyme monoamine oxidase type A (MAOA) due to genetic polymorphisms within the MAOA gene leads to increased brain neurotransmitter levels associated with aggression. In order to...

    Authors: James Sacco, Andrew Ruplin, Paul Skonieczny and Michael Ohman

    Citation: Canine Genetics and Epidemiology 2017 4:1

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  14. Content type: Research

    Despite decades of studying, the mechanisms maintaining high diversity in the genes of the Major Histocompatibility Complex (MHC) are still puzzling scientists. In addition to pathogen recognition and other fu...

    Authors: Alina K. Niskanen, Lorna J. Kennedy, Hannes Lohi, Jouni Aspi and Tanja Pyhäjärvi

    Citation: Canine Genetics and Epidemiology 2016 3:9

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  15. Content type: Research

    Intervertebral disc disease (IVDD) represents a major problem in the Dachshund, with at a relative risk of IVDD 10–12 times higher than other breeds, and an estimated 19–24 % of Dachshunds showing clinical sig...

    Authors: R. M. A. Packer, I. J. Seath, D. G. O’Neill, S. De Decker and H. A. Volk

    Citation: Canine Genetics and Epidemiology 2016 3:8

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  16. Content type: Research

    This study examines genetic diversity among 102 registered English Bulldogs used for breeding based on maternal and paternal haplotypes, allele frequencies in 33 highly polymorphic short tandem repeat (STR) lo...

    Authors: Niels C. Pedersen, Ashley S. Pooch and Hongwei Liu

    Citation: Canine Genetics and Epidemiology 2016 3:6

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  17. Content type: Research

    Progressive retinal atrophy (PRA) belongs to a group of inherited retinal disorders associated with gradual vision impairment due to degeneration of retinal photoreceptors in various dog breeds. PRA is highly ...

    Authors: Regina Kropatsch, Denis A. Akkad, Matthias Frank, Carsten Rosenhagen, Janine Altmüller, Peter Nürnberg, Jörg T. Epplen and Gabriele Dekomien

    Citation: Canine Genetics and Epidemiology 2016 3:7

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  18. Content type: Research

    The Pug is an ancient dog breed and was the fifth most commonly registered UK pedigree breed in 2014. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory a...

    Authors: Dan G. O’Neill, Elisabeth C. Darwent, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2016 3:5

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  19. Content type: Research

    Canine patellar luxation is one of the most common orthopaedic disorders of dogs and is a potential welfare concern because it can lead to lameness, osteoarthritis and pain. However, there are limited epidemio...

    Authors: Dan G. O’Neill, Richard L. Meeson, Adam Sheridan, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2016 3:4

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  20. Content type: Research

    Valued for trainability in diverse tasks, dogs are the primary service animal used to assist individuals with disabilities. Despite their utility, many people in need of service dogs are sensitive to the prima...

    Authors: Christina Breitenbuecher, Janelle M. Belanger, Kerinne Levy, Paul Mundell, Valerie Fates, Liza Gershony, Thomas R. Famula and Anita M. Oberbauer

    Citation: Canine Genetics and Epidemiology 2016 3:3

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  21. Content type: Research

    The morphology of dogs can provide information about their predisposition to some disorders. For example, larger breeds are predisposed to hip dysplasia and many neoplastic diseases. Therefore, longitudinal tr...

    Authors: Kendy T. Teng, Paul D. McGreevy, Jenny-Ann L. M. L. Toribio and Navneet K. Dhand

    Citation: Canine Genetics and Epidemiology 2016 3:2

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  22. Content type: Research

    The aims of this study were to: determine the prevalence of pectinate ligament dysplasia (PLD) in populations of Basset hounds (BH), Flatcoated retrievers (FCR) and Dandie Dinmont terriers (DDT) resident in th...

    Authors: James A. C. Oliver, Abel Ekiri and Cathryn S. Mellersh

    Citation: Canine Genetics and Epidemiology 2016 3:1

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  23. Content type: Research

    Previous studies documented the problem of inbreeding among Italian Greyhounds (IG) from the USA and its possible role in a multiple autoimmune disease syndrome. The present study is an extension of these earl...

    Authors: Niels C. Pedersen, Hongwei Liu, Angela Leonard and Layle Griffioen

    Citation: Canine Genetics and Epidemiology 2015 2:17

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  24. Content type: Research

    Next generation sequencing (NGS) has traditionally been performed by large genome centers, but in recent years, the costs for whole-genome sequencing (WGS) have decreased substantially. With the introduction o...

    Authors: Agnese Viluma, Shumaila Sayyab, Sofia Mikko, Göran Andersson and Tomas F. Bergström

    Citation: Canine Genetics and Epidemiology 2015 2:16

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