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  1. Rottweilers are reportedly predisposed to many disorders but accurate prevalence information relating to the general population are lacking. This study aimed to describe demography, mortality and commonly reco...

    Authors: Dan G. O’Neill, Wee Yin Seah, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2017 4:13

    Content type: Research

    Published on:

  2. Pure breeding of dogs has led to over 700 heritable disorders, of which almost 300 are Mendelian in nature. Seventy percent of the characterized mutations have an autosomal recessive mode of inheritance, indic...

    Authors: Niels C. Pedersen, Bonnie Shope and Hongwei Liu

    Citation: Canine Genetics and Epidemiology 2017 4:11

    Content type: Research

    Published on:

    The Letter to the Editor to this article has been published in Canine Genetics and Epidemiology 2018 5:4

  3. Studying cancer and other diseases poses a problem due to their protracted and multifactorial nature. Prospective studies are useful to investigate chronic disease processes since collection of lifestyle infor...

    Authors: Melissa Simpson, Erin Searfoss, Sharon Albright, Diane E. Brown, Barbara Wolfe, Nancy K. Clark, Susan E. McCann, David Haworth, Mike Guy and Rod Page

    Citation: Canine Genetics and Epidemiology 2017 4:14

    Content type: Research

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  4. Canine lumbosacral stenosis is defined as narrowing of the caudal lumbar and/or sacral vertebral canal. A risk factor for neurologic problems in many large sized breeds, lumbosacral stenosis can also cause ear...

    Authors: Meenakshi Mukherjee, Jeryl C. Jones and Jianbo Yao

    Citation: Canine Genetics and Epidemiology 2017 4:12

    Content type: Research

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  5. Genetic polymorphisms within the glutathione S-transferase P1 (GSTP1) gene affect the elimination of toxic xenobiotics by the GSTP1 enzyme. In dogs, exposure to environmental chemicals that may be GSTP1 substrate...

    Authors: James Sacco, Sarah Mann and Keller Toral

    Citation: Canine Genetics and Epidemiology 2017 4:9

    Content type: Research

    Published on:

  7. Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features. However, few studies empiric...

    Authors: B. M. Wiles, A. M. Llewellyn-Zaidi, K.M. Evans, D. G. O’Neill and T. W. Lewis

    Citation: Canine Genetics and Epidemiology 2017 4:8

    Content type: Research

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  8. The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are no...

    Authors: Dan G. O’Neill, Noel R. Coulson, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2017 4:7

    Content type: Research

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  9. Corneal ulcerative disease (CUD) has the potential to adversely affect animal welfare by interfering with vision and causing pain. The study aimed to investigate for the first time the prevalence, breed-based ...

    Authors: Dan G. O’Neill, Monica M. Lee, Dave C. Brodbelt, David B. Church and Rick F. Sanchez

    Citation: Canine Genetics and Epidemiology 2017 4:5

    Content type: Research

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  10. Gonadectomy, or neutering, is a very common surgery for dogs having many positive effects on behavior, health, and longevity. There are also certain risks associated with neutering including the development of...

    Authors: Janelle M. Belanger, Thomas P. Bellumori, Danika L. Bannasch, Thomas R. Famula and Anita M. Oberbauer

    Citation: Canine Genetics and Epidemiology 2017 4:6

    Content type: Research

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  11. Concentrated breeding effort to produce various body structures and behaviors of dogs to suit human demand has inadvertently produced unwanted traits and diseases that accompany the morphological and behaviora...

    Authors: Mark J. Fealey, Joy Li, Rebel J. E. Todhunter, Ursula Krotscheck, Kei Hayashi, Marina J. McConkey, Adam R. Boyko, Jessica J. Hayward and Rory J. Todhunter

    Citation: Canine Genetics and Epidemiology 2017 4:4

    Content type: Research

    Published on:

  12. Osteosarcoma is the most common neoplastic disease in Scottish Deerhounds. For Deerhounds, a 2007 population-based study concluded that a single dominant genetic factor largely governed disease risk. For Greyh...

    Authors: John E. Dillberger and Sara Ann McAtee

    Citation: Canine Genetics and Epidemiology 2017 4:3

    Content type: Research

    Published on:

  13. Exercise-induced collapse (EIC) due to DNM1 mutation and rupture of the cranial cruciate ligament are both common syndromes in the Labrador retriever breed. A cohort of 313 Labradors was recruited based on their ...

    Authors: Kari J Ekenstedt, Katie M Minor, Aaron K Rendahl and Michael G Conzemius

    Citation: Canine Genetics and Epidemiology 2017 4:2

    Content type: Research

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  14. In humans, reduced activity of the enzyme monoamine oxidase type A (MAOA) due to genetic polymorphisms within the MAOA gene leads to increased brain neurotransmitter levels associated with aggression. In order to...

    Authors: James Sacco, Andrew Ruplin, Paul Skonieczny and Michael Ohman

    Citation: Canine Genetics and Epidemiology 2017 4:1

    Content type: Research

    Published on:

  15. Despite decades of studying, the mechanisms maintaining high diversity in the genes of the Major Histocompatibility Complex (MHC) are still puzzling scientists. In addition to pathogen recognition and other fu...

    Authors: Alina K. Niskanen, Lorna J. Kennedy, Hannes Lohi, Jouni Aspi and Tanja Pyhäjärvi

    Citation: Canine Genetics and Epidemiology 2016 3:9

    Content type: Research

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  16. Intervertebral disc disease (IVDD) represents a major problem in the Dachshund, with at a relative risk of IVDD 10–12 times higher than other breeds, and an estimated 19–24 % of Dachshunds showing clinical sig...

    Authors: R. M. A. Packer, I. J. Seath, D. G. O’Neill, S. De Decker and H. A. Volk

    Citation: Canine Genetics and Epidemiology 2016 3:8

    Content type: Research

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  17. This study examines genetic diversity among 102 registered English Bulldogs used for breeding based on maternal and paternal haplotypes, allele frequencies in 33 highly polymorphic short tandem repeat (STR) lo...

    Authors: Niels C. Pedersen, Ashley S. Pooch and Hongwei Liu

    Citation: Canine Genetics and Epidemiology 2016 3:6

    Content type: Research

    Published on:

  18. Progressive retinal atrophy (PRA) belongs to a group of inherited retinal disorders associated with gradual vision impairment due to degeneration of retinal photoreceptors in various dog breeds. PRA is highly ...

    Authors: Regina Kropatsch, Denis A. Akkad, Matthias Frank, Carsten Rosenhagen, Janine Altmüller, Peter Nürnberg, Jörg T. Epplen and Gabriele Dekomien

    Citation: Canine Genetics and Epidemiology 2016 3:7

    Content type: Research

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  19. The Pug is an ancient dog breed and was the fifth most commonly registered UK pedigree breed in 2014. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory a...

    Authors: Dan G. O’Neill, Elisabeth C. Darwent, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2016 3:5

    Content type: Research

    Published on:

  20. Canine patellar luxation is one of the most common orthopaedic disorders of dogs and is a potential welfare concern because it can lead to lameness, osteoarthritis and pain. However, there are limited epidemio...

    Authors: Dan G. O’Neill, Richard L. Meeson, Adam Sheridan, David B. Church and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2016 3:4

    Content type: Research

    Published on:

  21. Valued for trainability in diverse tasks, dogs are the primary service animal used to assist individuals with disabilities. Despite their utility, many people in need of service dogs are sensitive to the prima...

    Authors: Christina Breitenbuecher, Janelle M. Belanger, Kerinne Levy, Paul Mundell, Valerie Fates, Liza Gershony, Thomas R. Famula and Anita M. Oberbauer

    Citation: Canine Genetics and Epidemiology 2016 3:3

    Content type: Research

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  22. The morphology of dogs can provide information about their predisposition to some disorders. For example, larger breeds are predisposed to hip dysplasia and many neoplastic diseases. Therefore, longitudinal tr...

    Authors: Kendy T. Teng, Paul D. McGreevy, Jenny-Ann L. M. L. Toribio and Navneet K. Dhand

    Citation: Canine Genetics and Epidemiology 2016 3:2

    Content type: Research

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  23. The aims of this study were to: determine the prevalence of pectinate ligament dysplasia (PLD) in populations of Basset hounds (BH), Flatcoated retrievers (FCR) and Dandie Dinmont terriers (DDT) resident in th...

    Authors: James A. C. Oliver, Abel Ekiri and Cathryn S. Mellersh

    Citation: Canine Genetics and Epidemiology 2016 3:1

    Content type: Research

    Published on:

  24. Previous studies documented the problem of inbreeding among Italian Greyhounds (IG) from the USA and its possible role in a multiple autoimmune disease syndrome. The present study is an extension of these earl...

    Authors: Niels C. Pedersen, Hongwei Liu, Angela Leonard and Layle Griffioen

    Citation: Canine Genetics and Epidemiology 2015 2:17

    Content type: Research

    Published on:

  25. Next generation sequencing (NGS) has traditionally been performed by large genome centers, but in recent years, the costs for whole-genome sequencing (WGS) have decreased substantially. With the introduction o...

    Authors: Agnese Viluma, Shumaila Sayyab, Sofia Mikko, Göran Andersson and Tomas F. Bergström

    Citation: Canine Genetics and Epidemiology 2015 2:16

    Content type: Research

    Published on:

  28. Sebaceous adenitis (SA) and Addison’s disease (AD) increased rapidly in incidence among Standard Poodles after the mid-twentieth century. Previous attempts to identify specific genetic causes using genome wide...

    Authors: Niels C. Pedersen, Lynn Brucker, Natalie Green Tessier, Hongwei Liu, Maria Cecilia T. Penedo, Shayne Hughes, Anita Oberbauer and Ben Sacks

    Citation: Canine Genetics and Epidemiology 2015 2:14

    Content type: Research

    Published on:

  29. Hypothyroidism is one of the most common endocrine disorders, whereas symmetrical onychomadesis is a rare claw disease in the general dog population. The aims of this study were to estimate the prevalence of h...

    Authors: Martine Lund Ziener, Stina Dahlgren, Stein Istre Thoresen and Frode Lingaas

    Citation: Canine Genetics and Epidemiology 2015 2:12

    Content type: Research

    Published on:

  30. Canine distichiasis is a well-known cause of ocular irritation and excessive lacrimation (secretion of tears) in the dog. The term distichiasis originates from the Greek words di and stichos meaning two and rows,...

    Authors: Tanja Petersen, Helle Friis Proschowsky, Tommy Hardon, Søren Nyhuus Rasch and Merete Fredholm

    Citation: Canine Genetics and Epidemiology 2015 2:11

    Content type: Research

    Published on:

  31. Brachycephalic dog breeds are increasingly common. Canine brachycephaly has been associated with upper respiratory tract (URT) disorders but reliable prevalence data remain lacking. Using primary-care veterina...

    Authors: Dan G. O’Neill, Caitlin Jackson, Jonathan H. Guy, David B. Church, Paul D. McGreevy, Peter C. Thomson and Dave C. Brodbelt

    Citation: Canine Genetics and Epidemiology 2015 2:10

    Content type: Research

    Published on:

  32. Analysis of 88,635 dogs seen at the University of California, Davis Veterinary Medical Teaching Hospital from 1995 to 2010 identified ten inherited conditions having greater prevalence within the purebred dog ...

    Authors: A. M. Oberbauer, J. M. Belanger, T. Bellumori, D. L. Bannasch and T. R. Famula

    Citation: Canine Genetics and Epidemiology 2015 2:9

    Content type: Research

    Published on:

  33. Cocker spaniels are predisposed to immune-mediated haemolytic anaemia (IMHA), suggesting that genetic factors influence disease susceptibility. Dog leukocyte antigen (DLA) class II genes encode major histocomp...

    Authors: Anna J. Threlfall, Alisdair M. Boag, Francesca Soutter, Barbara Glanemann, Harriet M. Syme and Brian Catchpole

    Citation: Canine Genetics and Epidemiology 2015 2:8

    Content type: Research

    Published on:

  34. A Norfolk terrier was referred to the Animal Health Trust neurology department with suspected dystrophin-deficient muscular dystrophy (DD-MD), which was confirmed by clinical workup and immunohistochemistry.

    Authors: Christopher A Jenkins and Oliver P Forman

    Citation: Canine Genetics and Epidemiology 2015 2:7

    Content type: Short report

    Published on:

  35. Working dog handlers and breeders have strong opinions on characteristics that are desirable in the breeds that they use to handle stock. Most of these characteristics are related to conformation or behaviour....

    Authors: Elizabeth R Arnott, Lincoln Peek, Jonathan B Early, Annie Y H Pan, Bianca Haase, Tracy Chew, Paul D McGreevy and Claire M Wade

    Citation: Canine Genetics and Epidemiology 2015 2:6

    Content type: Research

    Published on:

  36. The domestic dog represents an important model for studying the genetics of behavior. In spite of technological advances in genomics and phenomics, the genetic basis of most specific canine behaviors is largel...

    Authors: Denis A Akkad, Wanda M Gerding, Robin B Gasser and Jörg T Epplen

    Citation: Canine Genetics and Epidemiology 2015 2:5

    Content type: Research

    Published on:

  37. Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from...

    Authors: Jennifer F Summers, Dan G O’Neill, David B Church, Peter C Thomson, Paul D McGreevy and David C Brodbelt

    Citation: Canine Genetics and Epidemiology 2015 2:4

    Content type: Research

    Published on:

  38. The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnos...

    Authors: Lindsay L Farrell, Jeffrey J Schoenebeck, Pamela Wiener, Dylan N Clements and Kim M Summers

    Citation: Canine Genetics and Epidemiology 2015 2:3

    Content type: Review

    Published on:

  39. The breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18. Because this trait is dominant, heterozygous dogs cannot be discriminated from tho...

    Authors: Jennifer Turner Waldo and Kasandra Santana Diaz

    Citation: Canine Genetics and Epidemiology 2015 2:2

    Content type: Research

    Published on:

  40. Mast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk ...

    Authors: Stephanie JW Shoop, Stephanie Marlow, David B Church, Kate English, Paul D McGreevy, Anneliese J Stell, Peter C Thomson, Dan G O’Neill and David C Brodbelt

    Citation: Canine Genetics and Epidemiology 2015 2:1

    Content type: Research

    Published on:

  41. Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) considered to be the primary sensors of pathogens in innate immunity. Genetic variants could be associated to differences in breed innate imm...

    Authors: Anna Cuscó, Armand Sánchez, Laura Altet, Lluís Ferrer and Olga Francino

    Citation: Canine Genetics and Epidemiology 2014 1:11

    Content type: Research

    Published on:

  42. Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to o...

    Authors: Angela L Holder, James A Price, Jamie P Adams, Holger A Volk and Brian Catchpole

    Citation: Canine Genetics and Epidemiology 2014 1:10

    Content type: Research

    Published on:

  43. Syringomyelia (SM) is a painful neurological condition, prevalent in brachycephalic toy breeds including the Cavalier King Charles Spaniel (CKCS). In these breeds, SM is typically secondary to Chiari-like Malf...

    Authors: Thomas J Mitchell, Susan P Knowler, Henny van den Berg, Jane Sykes and Clare Rusbridge

    Citation: Canine Genetics and Epidemiology 2014 1:9

    Content type: Research

    Published on:

  44. Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenc...

    Authors: Andrea D Short, Angela Holder, Simon Rothwell, Jonathan Massey, Rachel Scholey, Lorna J Kennedy, Brian Catchpole and William ER Ollier

    Citation: Canine Genetics and Epidemiology 2014 1:8

    Content type: Research

    Published on:

  45. Canine behaviours that are both desirable and undesirable to owners have a demonstrable genetic component. Some behaviours are breed-specific, such as the livestock guarding by maremmas and flank sucking seen ...

    Authors: Diane van Rooy, Elizabeth R Arnott, Jonathan B Early, Paul McGreevy and Claire M Wade

    Citation: Canine Genetics and Epidemiology 2014 1:7

    Content type: Review

    Published on:

  47. This paper addresses the use of cohort studies in canine medicine to date and highlights the benefits of wider use of such studies in the future. Uniquely amongst observational studies, cohort studies offer th...

    Authors: Carys A Pugh, Barend M de C Bronsvoort, Ian G Handel, Kim M Summers and Dylan N Clements

    Citation: Canine Genetics and Epidemiology 2014 1:5

    Content type: Review

    Published on:

  48. Generalized progressive retinal atrophy (PRA) is a group of inherited eye diseases characterised by progressive retinal degeneration that ultimately leads to blindness in dogs. To date, more than 20 different ...

    Authors: Louise M Downs, Berit Wallin-Håkansson, Tomas Bergström and Cathryn S Mellersh

    Citation: Canine Genetics and Epidemiology 2014 1:4

    Content type: Research

    Published on:

  49. Effective canine health surveillance systems can be used to monitor disease in the general population, prioritise disorders for strategic control and focus clinical research, and to evaluate the success of the...

    Authors: Dan G O’Neill, David B Church, Paul D McGreevy, Peter C Thomson and Dave C Brodbelt

    Citation: Canine Genetics and Epidemiology 2014 1:2

    Content type: Review

    Published on:

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Canine Medicine and Genetics

ISSN: 2662-9380