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Research
Analysis of 88,635 dogs seen at the University of California, Davis Veterinary Medical Teaching Hospital from 1995 to 2010 identified ten inherited conditions having greater prevalence within the purebred dog ...
Canine Genetics and Epidemiology 2015 2:9
Published on: 11 July 2015
Research
Cocker spaniels are predisposed to immune-mediated haemolytic anaemia (IMHA), suggesting that genetic factors influence disease susceptibility. Dog leukocyte antigen (DLA) class II genes encode major histocomp...
Canine Genetics and Epidemiology 2015 2:8
Published on: 9 June 2015
Short report
A Norfolk terrier was referred to the Animal Health Trust neurology department with suspected dystrophin-deficient muscular dystrophy (DD-MD), which was confirmed by clinical workup and immunohistochemistry.
Canine Genetics and Epidemiology 2015 2:7
Published on: 14 May 2015
Research
Working dog handlers and breeders have strong opinions on characteristics that are desirable in the breeds that they use to handle stock. Most of these characteristics are related to conformation or behaviour....
Canine Genetics and Epidemiology 2015 2:6
Published on: 7 May 2015
Research
Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from...
Canine Genetics and Epidemiology 2015 2:4
Published on: 18 April 2015
Research
The domestic dog represents an important model for studying the genetics of behavior. In spite of technological advances in genomics and phenomics, the genetic basis of most specific canine behaviors is largel...
Canine Genetics and Epidemiology 2015 2:5
Published on: 18 April 2015
Review
The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnos...
Canine Genetics and Epidemiology 2015 2:3
Published on: 11 February 2015
Research
The breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18. Because this trait is dominant, heterozygous dogs cannot be discriminated from tho...
Canine Genetics and Epidemiology 2015 2:2
Published on: 27 January 2015
Research
Mast cell tumour (MCT) appears to be a frequent tumour type in dogs, though there is little published in relation to its frequency in dogs in the UK. The current study aimed to investigate prevalence and risk ...
Canine Genetics and Epidemiology 2015 2:1
Published on: 26 January 2015
Research
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) considered to be the primary sensors of pathogens in innate immunity. Genetic variants could be associated to differences in breed innate imm...
Canine Genetics and Epidemiology 2014 1:11
Published on: 22 October 2014
Research
Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to o...
Canine Genetics and Epidemiology 2014 1:10
Published on: 25 September 2014
Research
Syringomyelia (SM) is a painful neurological condition, prevalent in brachycephalic toy breeds including the Cavalier King Charles Spaniel (CKCS). In these breeds, SM is typically secondary to Chiari-like Malf...
Canine Genetics and Epidemiology 2014 1:9
Published on: 29 July 2014
Research
Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenc...
Canine Genetics and Epidemiology 2014 1:8
Published on: 7 July 2014
Review
Canine behaviours that are both desirable and undesirable to owners have a demonstrable genetic component. Some behaviours are breed-specific, such as the livestock guarding by maremmas and flank sucking seen ...
Canine Genetics and Epidemiology 2014 1:7
Published on: 10 June 2014
Short report
During routine diagnostic BAER testing of dogs of various breeds for private owners at the Western College of Veterinary Medicine in Saskatoon, it became evident that some individual dogs developed hearing los...
Canine Genetics and Epidemiology 2014 1:6
Published on: 28 May 2014
Review
This paper addresses the use of cohort studies in canine medicine to date and highlights the benefits of wider use of such studies in the future. Uniquely amongst observational studies, cohort studies offer th...
Canine Genetics and Epidemiology 2014 1:5
Published on: 15 May 2014
Review
Inherited forms of eye disease are arguably the best described and best characterized of all inherited diseases in the dog, at both the clinical and molecular level and at the time of writing 29 different muta...
Canine Genetics and Epidemiology 2014 1:3
Published on: 16 April 2014
Research
Generalized progressive retinal atrophy (PRA) is a group of inherited eye diseases characterised by progressive retinal degeneration that ultimately leads to blindness in dogs. To date, more than 20 different ...
Canine Genetics and Epidemiology 2014 1:4
Published on: 16 April 2014
Review
Effective canine health surveillance systems can be used to monitor disease in the general population, prioritise disorders for strategic control and focus clinical research, and to evaluate the success of the...
Canine Genetics and Epidemiology 2014 1:2
Published on: 16 April 2014
Editorial
Canine Genetics and Epidemiology 2014 1:1
Published on: 16 April 2014
